Jun Zhang

US Patent:

6693077, Feb 17, 2004

Filed:

Jun 30, 2000

Appl. No.:

09/610651

Inventors:

Steven M. Ruben - Brookeville MD
Pablo Jimenez - Chatham NJ
D. Roxanne Duan - Gaithersburg MD
Mark A. Rampy - Montgomery Village MD
Donna Mendrick - Mount Airy MD
Jun Zhang - San Diego CA
Jian NI - Germantown MD
Paul A. Moore - North Bethesda MD
Timothy A. Coleman - Gaithersburg MD
Joachim R. Gruber - Dallas TX
Patrick J. Dillon - Carlsbad CA
Reiner L. Gentz - Belo Horizonte-Mg, BR

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3818

US Classification:

514 12, 514 2, 530399

Abstract:

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as âKGF-2â also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

US Patent:

6898212, May 24, 2005

Filed:

Nov 14, 2000

Appl. No.:

09/713778

Inventors:

Dexter Chun - San Diego CA, US
Manoj Deshpande - San Diego CA, US
Steve Hicks - San Diego CA, US
Bob Knight - San Diego CA, US
KC Lee - San Diego CA, US
Ravi Palakodety - San Diego CA, US
Ramesh Ramaswamy - San Diego CA, US
Gustavo Serena - San Diego CA, US
Dave Walker - Escondido CA, US
Jun Zhang - San Diego CA, US

Assignee:

Telefonaktiebolaget LM Ericsson (publ)

International Classification:

H04J003/06

US Classification:

370503, 370547

Abstract:

A Base Station Controller (BSC) that reduces the occurrence of audible noise in a Code Division Multiple Access (CDMA) radio network is provided. The BSC according to one embodiment of the present invention comprises a Media Stream Board (MSB) for compressing groups of 160 PCM speech samples from a Public Switch Telephone Network (PSTN) into vocoded frames, and a Special Purpose Board (SPB) for reformatting the vocoded frames from the MSB into over-the-air CDMA vocoded frames. The MSB and SPB each have a local timer that is slave to “PSTN time”. The BSC further comprises a Timing Unit Board (TUB) connected to a GPS receiver. The TUB receives “GPS time” from the GPS receiver. The TUB generates timing cells, each containing time-of-day information according to “GPS time”. The TUB distributes the timing cells to the MSB and the SPB over an Asynchronous Transfer Mode (ATM) network. The MSB and SPB use the received timing cells to compare their local timer, which tracks “PSTN time”, to “GPS time”.

US Patent:

7041460, May 9, 2006

Filed:

Jul 25, 2003

Appl. No.:

10/626530

Inventors:

Reiner L. Gentz - Belo Horizonte-Mg, BR
Brent L. Kreider - Bedford MA, US
Jun Zhang - San Diego CA, US
Michael Antonaccio - New Hope PA, US
Donna Mendrick - Mount Airy MD, US
Pablo Jimenez - Chatham NJ, US
Vikram Patel - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Mark D. Adams - Rockville MD, US
Haodong Li - Gaithersburg MD, US
Steven M. Ruben - Brookeville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 16/24
C12N 5/12
G01N 33/53

US Classification:

435 71, 435325, 435326, 435 149, 53038823, 5303871, 5303879, 5303881, 5303891, 5303873

Abstract:

There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

US Patent:

7092409, Aug 15, 2006

Filed:

Mar 21, 2001

Appl. No.:

09/814658

Inventors:

Dexter Chun - San Diego CA, US
Steve Hicks - San Diego CA, US
Bob Knight - San Diego CA, US
KC Lee - San Diego CA, US
Ravi Palakodety - San Diego CA, US
Dave Walker - Escondido CA, US
Jun Zhang - San Diego CA, US

Assignee:

Telefonaktiebolaget LM Ericsson (publ)

International Classification:

H04L 12/42

US Classification:

370507

Abstract:

A timing network for a wireless communication network includes first and second Timing Unit Board (TUB) and processor boards for processing speech channels of the radio network, each processor board having a local timer that is slave to “PSTN time” from a Public Switch Telephone Network (PSTN). The first and second TUB each alternately transmits a timing cell containing time information to each processor board over a transport network. Each processor board realigns its local timer with the time information contained in a received timing cell whenever its local timer drifts from the time information contained in the received timing cell by a predetermined time offset. When one of the TUBs fails to transmit timing cells to the processor boards or transmits timing cells containing erroneous time information, the processor boards rely on the remaining TUB for timing cells to realign their local timers.

US Patent:

7232667, Jun 19, 2007

Filed:

Dec 12, 2003

Appl. No.:

10/733311

Inventors:

Steven M. Ruben - Brookeville MD, US
Joachim R. Gruber - Dallas TX, US
D. Roxanne Duan - Gaithersburg MD, US
Mark A. Rampy - Montgomery Village MD, US
Donna Mendrick - Mount Airy MD, US
Jun Zhang - San Diego CA, US
Jian Ni - Germantown MD, US
Paul A. Moore - Germantown MD, US
Timothy A. Coleman - Gaithersburg MD, US
Patrick J. Dillon - Carlsbad CA, US
Reiner L. Gentz - Belo Horizonte-Mg, BR
Pablo Jimenez - Chatham NJ, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 1/21
C12N 5/10
C12N 15/12
C12N 15/63
C07K 14/50

US Classification:

435 694, 435 697, 435325, 435243, 4353201, 536 234, 536 2351, 530399

Abstract:

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

US Patent:

7364865, Apr 29, 2008

Filed:

May 5, 2006

Appl. No.:

11/381977

Inventors:

Reiner L. Gentz - Gauting, DE
Brent L. Kreider - Bedford MA, US
Jun Zhang - San Diego CA, US
Michael Antonaccio - New Hope PA, US
Donna Mendrick - Mount Airy MD, US
Pablo Jimenez - Chatham NJ, US
Vikram Patel - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Mark D. Adams - Cleveland Heights OH, US
Haodong Li - Gaithersburg MD, US
Steven M. Ruben - Brookeville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 5/10
C12N 5/12
G01N 33/53
C07K 16/24

US Classification:

435 71, 5303871, 5303873, 5303879, 53038823, 5303881, 435325, 435326

Abstract:

There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

US Patent:

7820798, Oct 26, 2010

Filed:

Aug 10, 2007

Appl. No.:

11/837082

Inventors:

Guo-Liang Yu - Berkeley CA, US
Jian Ni - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Jun Zhang - San Diego CA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 16/28
C07K 16/18
C07K 16/22
C07K 16/46
C12N 5/00
G01N 33/53

US Classification:

5303882, 5303871, 5303873, 5303881, 5303891, 435 71, 435326

Abstract:

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

US Patent:

7851596, Dec 14, 2010

Filed:

Apr 28, 2008

Appl. No.:

12/111079

Inventors:

Reiner L. Gentz - Belo Horizonte, BR
Brent L. Kreider - Bedford MA, US
Jun Zhang - San Diego CA, US
Michael Antonaccio - New Hope PA, US
Donna Mendrick - Mount Airy MD, US
Pablo Jimenez - Chatham NJ, US
Vikram Patel - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Mark D. Adams - Cleveland Heights OH, US
Haodong Li - Gaithersburg MD, US
Steven M. Ruben - Brookeville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 14/52

US Classification:

530351, 530350, 530326, 530327, 530328, 530329

Abstract:

There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.