Jun R Zhang

US Patent:

6495520, Dec 17, 2002

Filed:

Feb 19, 1999

Appl. No.:

09/252656

Inventors:

Reinhard Ebner - Gaithersburg MD
Guo-Liang Yu - Berkeley CA
Steven M. Ruben - Olney MD
Jun Zhang - Bethesda MD
Stephen Ullrich - Rockville MD
Yifan Zhai - Gaithersburg MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3818

US Classification:

514 12, 530300, 530324, 530350

Abstract:

The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.

US Patent:

6683894, Jan 27, 2004

Filed:

Apr 19, 2000

Appl. No.:

09/552579

Inventors:

Hyo Sang Lee - Silver Spring MD
Coorg R. Prasad - Silver Spring MD
Jun Zhang - Ellicott City MD

Assignee:

Science Engineering Services, Inc. - Burtonsville MD

International Classification:

H01S 310

US Classification:

372 20, 372 21, 372 22, 372 10, 372 30, 372101, 372105

Abstract:

A diode pumped solid state laser/OPO system widely tunable in mid infrared spectrum for infrared matrix assisted laser desorption/ionization (MALDI) mass spectroscopy is disclosed. Up to a few tens of milli-Joule, short pulse, tunable near infrared laser pulse is generated from an all solid state laser at a high pulse repetition rate up to one kHz. The tunable near-infrared laser pumps a Quasi-Phase Matching (QPM) OPO system to further shift the wavelength to the mid-IR range and to broaden the tuning range to as much as 3 m to effectively generate a widely tunable spectral output. The wide range tuning of the infrared output is accomplished by a narrow range tuning of the pump laser. The pump laser output is generated by a diode pumped tunable solid state laser module using either a Yb:YAG crystal or any other efficient tunable laser crystals. The wavelength range (2-5 m) covered by the solid state laser system is optimum for MALDI applications. This wavelength range is especially beneficial for large mass DNA analysis.

US Patent:

6693077, Feb 17, 2004

Filed:

Jun 30, 2000

Appl. No.:

09/610651

Inventors:

Steven M. Ruben - Brookeville MD
Pablo Jimenez - Chatham NJ
D. Roxanne Duan - Gaithersburg MD
Mark A. Rampy - Montgomery Village MD
Donna Mendrick - Mount Airy MD
Jun Zhang - San Diego CA
Jian NI - Germantown MD
Paul A. Moore - North Bethesda MD
Timothy A. Coleman - Gaithersburg MD
Joachim R. Gruber - Dallas TX
Patrick J. Dillon - Carlsbad CA
Reiner L. Gentz - Belo Horizonte-Mg, BR

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3818

US Classification:

514 12, 514 2, 530399

Abstract:

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as âKGF-2â also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

US Patent:

6811773, Nov 2, 2004

Filed:

May 15, 2000

Appl. No.:

09/571013

Inventors:

Reiner L. Gentz - Silver Spring MD
Brent L. Kreider - Germantown MD
Jun Zhang - Bethesda MD
Michael Antonaccio - Germantown MD
Donna Mendrick - Mt. Airy MD
Pablo Jimenez - Ellicott City MD
Vikram Patel - Germantown MD
Craig A. Rosen - Laytonsville MD
Mark D. Adams - North Potomac MD
Haodong Li - Gaithersburg MD
Steven M. Ruben - Olney MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3819

US Classification:

424 851, 530324, 514 2, 514 8, 514 12, 536 235, 435 695, 435 697, 435 711, 435 712, 435471, 4352523, 43525411, 4353201

Abstract:

There are disclosed therapeutic compositions and methods using a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1- chemokine 1(CK1 or ckb-1)), as well as ioslated nucleic acid molecules encoding M-CIF, and vectors, host cells and recombinant methods for producing the same.

US Patent:

6903072, Jun 7, 2005

Filed:

Jul 1, 1999

Appl. No.:

09/345373

Inventors:

Steven M. Ruben - Olney MD, US
Pablo Jimenez - Ellicott City MD, US
D. Roxanne Duan - Bethesda MD, US
Mark A. Rampy - Gaithersburg MD, US
Donna Mendrick - Mt. Airy MD, US
Jun Zhang - Bethesda MD, US
Jian Ni - Rockville MD, US
Paul A. Moore - Germantown MD, US
Timothy A. Coleman - Gaithersburg MD, US
Joachim R. Gruber - Chestnut Hill MA, US
Patrick J. Dillon - Carlsbad CA, US
Reiner L. Gentz - Rockville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K038/18
C07K014/50
C12N015/18
C12N001/21

US Classification:

514 12, 514 2, 530399, 530402, 435 694, 435 697, 435243

Abstract:

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

US Patent:

6916786, Jul 12, 2005

Filed:

Feb 15, 2002

Appl. No.:

10/075446

Inventors:

Steven M. Ruben - Olney MD, US
Pablo Jimenez - Ellicot City MD, US
D. Roxanne Duan - Bethesda MD, US
Mark A. Rampy - Montgomery Village MD, US
Donna Mendrick - Mount Airy MD, US
Jun Zhang - Bethesda MD, US
Jian Ni - Rockville MD, US
Paul A. Moore - Germantown MD, US
Timothy A. Coleman - Gaithersburg MD, US
Joachim R. Gruber - Dallas TX, US
Patrick J. Dillon - Carlsbad CA, US
Reiner L. Gentz - Rockville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K038/18
C07K014/50
C12N001/20
C12N005/10

US Classification:

514 12, 530399, 435 694, 435 697, 435243

Abstract:

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

US Patent:

7232667, Jun 19, 2007

Filed:

Dec 12, 2003

Appl. No.:

10/733311

Inventors:

Steven M. Ruben - Brookeville MD, US
Joachim R. Gruber - Dallas TX, US
D. Roxanne Duan - Gaithersburg MD, US
Mark A. Rampy - Montgomery Village MD, US
Donna Mendrick - Mount Airy MD, US
Jun Zhang - San Diego CA, US
Jian Ni - Germantown MD, US
Paul A. Moore - Germantown MD, US
Timothy A. Coleman - Gaithersburg MD, US
Patrick J. Dillon - Carlsbad CA, US
Reiner L. Gentz - Belo Horizonte-Mg, BR
Pablo Jimenez - Chatham NJ, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 1/21
C12N 5/10
C12N 15/12
C12N 15/63
C07K 14/50

US Classification:

435 694, 435 697, 435325, 435243, 4353201, 536 234, 536 2351, 530399

Abstract:

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

US Patent:

7503070, Mar 10, 2009

Filed:

Mar 15, 2005

Appl. No.:

11/080708

Inventors:

Marshall Van Alstyne - West Newton MA, US
Jun Zhang - Ann Arbor MI, US

International Classification:

G06F 21/00

US Classification:

726 22

Abstract:

Disclosed are methods and systems for enabling analysis of communication content while preserving confidentiality. In one embodiment, communication content is processed to increase the similarity of superficially dissimilar instances of communication content and/or to increase the distinctiveness of superficially similar instances of communications content. In this embodiment at least part of the processed communication content is hashed to obscure the actual communication content. In one embodiment, social network analysis is performed on the communication content after hashing, and visualization of the social network analysis includes thread graphs and/or circular graphs.