Junwei Li

US Patent:

20110200828, Aug 18, 2011

Filed:

Feb 7, 2011

Appl. No.:

13/021811

Inventors:

Junwei Li - Collegeville PA, US
William J. Work - Huntingdon Valley PA, US

Assignee:

BIOCOAT INCORPORATED - Horsham PA

International Classification:

B32B 27/08
B32B 27/00
B32B 27/30
B32B 27/40
B32B 27/18

US Classification:

428414, 428704, 428522, 4284744, 4284231

Abstract:

Biocompatible, lubricious, highly durable coatings for medical devices are formed from a highly adherent base-coat and a hydrophilic top-coat that is chemically grafted to the base-coat and has a chemically cross-linked structure. The base-coat constitutes a carboxylic acid containing polymer. The top-coat includes a carboxylic acid containing hydrophilic polymer and chromium (III) ion as the cross-linking agent. The coating possesses biocompatibility and gamma ray-sterilization stability. The coated products in aqueous media display an unmatched combination of lubricity, abrasion resistance, and chemical stability.

US Patent:

20130323291, Dec 5, 2013

Filed:

May 31, 2012

Appl. No.:

13/484897

Inventors:

Junwei Li - Collegeville PA, US
William J. Work - Huntingdon Valley PA, US

Assignee:

BIOCOAT INCORPORATED - Horsham PA

International Classification:

C09D 133/26
C08K 5/09
B32B 27/08
A61P 31/00
B32B 27/28
C09D 139/06
A61K 9/00

US Classification:

424409, 524548, 524555, 524300, 522167, 522175, 523122, 524502, 424400, 428500, 428520, 4284242

Abstract:

A hydrophilic copolymer is designed and synthesized by copolymerization of an acidic monomer and a second hydrophilic monomer. The copolymer is non-thrombogenic, hydrophilic and incorporates reactive functional groups. The copolymer can then be covalently attached to a primer/base coat through its functional groups, to form a durable lubricious coating on medical devices. A coating formed of the polymer on a surface is non-thrombogenic and non-cytotoxic. The coating shows good stability in gamma ray, e-beam and ethylene oxide sterilization.

US Patent:

20170253636, Sep 7, 2017

Filed:

Mar 1, 2017

Appl. No.:

15/446315

Inventors:

- Lubbock TX, US
Maria T. Arevalo - Athens GA, US
Junwei Li - El Paso TX, US

International Classification:

C07K 14/005
G01N 33/50
A61K 39/145

Abstract:

The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.

US Patent:

20170232097, Aug 17, 2017

Filed:

Oct 14, 2015

Appl. No.:

15/518781

Inventors:

- Lubbock TX, US
Junwei Li - El Paso TX, US

International Classification:

A61K 39/145
C12N 15/113
C12N 15/86
C12N 7/00

Abstract:

The present invention includes a live attenuated virus and methods of making the same comprising an isolated virus comprising a viral genome that expresses one or more viral antigens; and one or more exogenous species-specific microRNAs inserted into the viral genome and expressed thereby, wherein the species-specific microRNAs are ubiquitously expressed in a viral target species cell but not in a viral propagation cell.

US Patent:

20160151480, Jun 2, 2016

Filed:

Jul 9, 2014

Appl. No.:

14/903611

Inventors:

- Lubbock TX, US
Junwei Li - El Paso TX, US

International Classification:

A61K 39/145
A61K 39/39
G01N 33/569
C12N 7/00

Abstract:

The present invention includes an isolated antigen against influenza A and a method of making the same that includes an ectodomain of influenza A Matrix Protein 2 (M2e) and a stem region of an influenza A hemagglutinin 2 (HA2) protein and an adjuvant. The invention further includes formulating the antigen into an isolated immune response stimulating fusion protein and/or a vaccine.