Kai Tim Cheng

US Patent:

20020087766, Jul 4, 2002

Filed:

Dec 29, 2000

Appl. No.:

09/751623

Inventors:

Akhilesh Kumar - Sunnyvale CA, US
Manoj Khare - Saratoga CA, US
Lily Looi - Portland OR, US
Ling Cen - Austin TX, US
Kenneth Creta - Gig Harbor WA, US
Steve Kulick - Portland OR, US
Kai Cheng - Portland OR, US
Robert George - Austin TX, US
Sin Tan - Portland OR, US

International Classification:

G06F013/00

US Classification:

710/108000

Abstract:

In a multi-node system, a method and apparatus to implement a locked-bus transaction is described. In one embodiment, a bus agent initiates a locked-bus transaction and a node controller defers the transaction so that it will be initiated again at a later time. The node controller then sends the locked bus request to one or more other node controllers in the system, which prevent bus transaction at their respective busses. Once the requesting node controller receives confirmation that the other nodes are locked, it can allow the locked-bus transaction to proceed from the bus agent.

US Patent:

20130052131, Feb 28, 2013

Filed:

Aug 24, 2012

Appl. No.:

13/593907

Inventors:

Zhen Cheng - Mountain View CA, US
Kai Cheng - Mountain View CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 49/00
G01N 29/14
C07K 2/00
C07H 21/00
C08B 37/00
C07J 51/00
C07F 19/00
A61K 38/02
A61K 31/715
A61K 39/00
A61K 31/282
A61K 31/56
A61K 31/555
A61P 35/00
A61P 37/04
A61K 49/22
C07H 23/00
A61K 51/02
A61K 31/7135
B22F 1/00
B32B 15/02
G01N 21/65
B82Y 5/00
B82Y 15/00

US Classification:

424 161, 435 723, 435 61, 435 71, 435 29, 530300, 530400, 536 231, 536121, 552504, 556110, 544225, 424 91, 514 11, 514 54, 4241931, 514495, 514169, 514184, 514186, 424 95, 514 23, 514 44 R, 420591, 428402, 977906, 977904, 977774, 977927

Abstract:

Embodiments of the present disclosure, in one aspect, relate to a nanoparticle, methods of imaging a tumor, method of imaging a disease, method of treating a condition, disease, or related biological event, or the like.

US Patent:

20190192761, Jun 27, 2019

Filed:

Nov 12, 2018

Appl. No.:

16/186947

Inventors:

- Stanford CA, US
Xuechuan HONG - Wuhan City, CN
Hongjie DAI - Cupertino CA, US
Hao CHEN - Wuhan City, CN
Alexander ANTARIS - Stanford CA, US
Kai CHENG - Mountain View CA, US

International Classification:

A61M 5/00
A61K 47/60
C09B 57/00
A61K 49/00
A61K 49/22
C07K 14/765
A61K 41/00

Abstract:

Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.

US Patent:

20160244614, Aug 25, 2016

Filed:

Feb 23, 2016

Appl. No.:

15/051563

Inventors:

- Stanford CA, US
Xuechuan HONG - Wuhan City, CN
Hongjie DAI - Cupertino CA, US
Hao CHEN - Wuhan City, CN
Alexander ANTARIS - Stanford CA, US
Kai Cheng - Mountain View CA, US

International Classification:

C09B 49/04
A61K 49/00
A61B 5/00
A61K 49/22
A61M 5/00
C07K 14/765
A61K 41/00

Abstract:

Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.

US Patent:

20140356283, Dec 4, 2014

Filed:

May 28, 2014

Appl. No.:

14/288441

Inventors:

- Palo Alto CA, US
Quli Fan - Nanjing, CN
Kai Cheng - Sunnyvale CA, US
Xiang Hu - Wuhan, CN

International Classification:

A61K 49/22
A61K 49/12
A61K 49/04
A61K 49/18

US Classification:

424 165, 428402, 424 91, 424 93, 548455, 435 29

Abstract:

Embodiments of the present disclosure provide for water soluble polyethylene glycol (PEG)-polymeric melanin (PEG-melanin) nanoparticles, methods of using the PEG-melanin nanoparticle, methods of making the PEG-melanin nanoparticle, methods of imaging a diseases or condition (e.g., pre-cancerous tissue, cancer, or a tumor), and the like. Embodiments of the present disclosure can be used in multimodal imaging (e.g., photoacoustic, nuclear, magnetic, fluorescent, and the like).