Karel F Bernady from 2 Saint Anthony Ln, Chester Springs, PA 19425, age 84, Phone: (610)8270113

Amide Derivatives Of 9-Oxo-13-Trans-Prostenoic Acid
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US Patent:

40546047, Oct 18, 1977
Filed:

May 13, 1976
Appl. No.:

5/685943
Inventors:

Karel Francis Bernady - Suffern NY
Middleton Brawner Floyd - Suffern NY
John Frank Poletto - Nanuet NY
Robert Eugene Schaub - Upper Saddle River NJ
Martin Joseph Weiss - Oradell NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07C10319
A61K 3116
US Classification:

260557R
Abstract:

This disclosure describes homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenamide and of 9-hydroxy-13-trans-prostenamide, having antimicrobial activity and prostaglandin-like hypotensive activity.

3-Alkyl-2-(6-Carboxyhexyl) Cyclopentanones And Esters And Salts Thereof
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US Patent:

40740560, Feb 14, 1978
Filed:

Jan 4, 1977
Appl. No.:

5/756667
Inventors:

Robert E. Schaub - Upper Saddle River NJ
Karel F. Bernady - Suffern NY
Martin J. Weiss - Oradell NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07C17700
US Classification:

560 51
Abstract:

This disclosure describes compounds of the class of substituted 9-oxoprostanoic acids and the esters and cationic salts thereof, useful as antimicrobial agents, hypotensive agents, anti-ulcer agents, or as intermediates, and novel processes for preparing the same.

2-Substituted-3,4-Epoxycyclopentan-1-Ones, And 2-Substituted-3,4-Epoxycyclopentan-1-Ols
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US Patent:

39667731, Jun 29, 1976
Filed:

Aug 11, 1975
Appl. No.:

5/603466
Inventors:

Karel Francis Bernady - Suffern NY
Middleton Brawner Floyd - Suffern NY
John Frank Poletto - Nanuet NY
Robert Eugene Schaub - Upper Saddle River NJ
Martin Joseph Weiss - Oradell NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07D30338
US Classification:

260348C
Abstract:

This disclosure describes 2-substituted-3,4-epoxy-cyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.

Novel 3-Triphenylmethoxy-1-Alkynes, 3-Triphenyl-Methoxy-1-Trans-Alkenyl-Dialkyl-Alanes, And Lithium 3-Triphenylmethoxy-1-Trans-Alkenyl-Dialkyl Alanates
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US Patent:

40605400, Nov 29, 1977
Filed:

Nov 5, 1976
Appl. No.:

5/739174
Inventors:

Karel Francis Bernady - Suffern NY
Middleton Brawner Floyd - Suffern NY
John Frank Poletto - Nanuet NY
Robert Eugene Schaub - Upper Saddle River NJ
Martin Joseph Weiss - Oradell NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07F 718
US Classification:

2604488R
Abstract:

This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.

Lithium 3-Triphenylmethoxy-1-Trans-Alkenyl-Dialkyl Alanates
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US Patent:

39324796, Jan 13, 1976
Filed:

Apr 27, 1973
Appl. No.:

5/355350
Inventors:

Karel Francis Bernady - Suffern NY
Middleton Brawner Floyd - Suffern NY
John Frank Poletto - Nanuet NY
Robert Eugene Schaub - Upper Saddle River NJ
Martin Joseph Weiss - Oradell NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07F 506
US Classification:

260448A
Abstract:

This disclosure describes 3-triphenylmethoxy-1-alkynes, 3-triphenylmethoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.

Novel 2-Substituted-3,4-Epoxycyclopentan-1-Ones, 2-Substituted-3,4-Epoxycyclopentan-1-Ols, And Various 2-Substituted-Cyclopentenones
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US Patent:

43439497, Aug 10, 1982
Filed:

Oct 12, 1979
Appl. No.:

6/084237
Inventors:

Karel F. Bernady - Suffern NY
Middleton B. Floyd - Suffern NY
John F. Poletto - Nanuet NY
Robert E. Schaub - Upper Saddle River NJ
Martin J. Weiss - Oradell NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07C 51353
C07C17700
US Classification:

562503
Abstract:

This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.

Novel Hydroxy Substituted Prostanoic Acids, Esters, Congeners, Intermediates And Process
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US Patent:

44393652, Mar 27, 1984
Filed:

Jul 18, 1979
Appl. No.:

6/058415
Inventors:

Middleton B. Floyd - Suffern NY
Martin J. Weiss - Oradell NJ
John F. Poletto - Nanuet NY
Robert E. Schaub - Upper Saddle River NJ
Karel F. Bernady - Belle Mead NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C09B 1106
US Classification:

260395
Abstract:

This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.

Novel 2-Substituted-3,4-Epoxycyclopentan-1-Ones, 2-Substituted-3,4-Epoxycyclopentan-1-Ols, And Various 2-Substituted-Cyclo-Pentenones
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US Patent:

41795741, Dec 18, 1979
Filed:

Sep 22, 1977
Appl. No.:

5/835613
Inventors:

Karel F. Bernady - Suffern NY
Middleton B. Floyd - Suffern NY
John F. Poletto - Nanuet NY
Robert E. Schaub - Upper Saddle River NJ
Martin J. Weiss - Oradell NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07C 1138
US Classification:

562503
Abstract:

This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-prostenoic acid derivatives which possess bronchodilator, hypotensive, and anti-ulcer activity.

Karel F Bernady