Karen Ann Potter

US Patent:

20090311280, Dec 17, 2009

Filed:

Dec 9, 2005

Appl. No.:

11/721308

Inventors:

Timothy C. Cheung - La Mesa CA, US
Ian R. Humphreys - Del Mar CA, US
Karen G. Potter - San Diego CA, US
Christopher A. Benedict - Encinitas CA, US
Carl F. Ware - Solana Beach CA, US
Carl De Trez - San Diego CA, US
Michael Croft - San Diego CA, US
Mitchell Kronenberg - Del Mar CA, US

Assignee:

LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY - La Jolla CA

International Classification:

A61K 39/00
C07K 7/00
C07K 7/06
C07K 7/08
C07K 14/045
C07K 14/435
C12N 15/11
C07K 16/28
C07K 16/08
C07K 1/00
C12N 5/06
A61K 38/16

US Classification:

4241851, 530330, 530329, 530328, 530327, 530326, 530325, 530324, 530350, 536 234, 5303879, 5303873, 530402, 435375, 514 12, 536 2372

Abstract:

Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation.

US Patent:

8349320, Jan 8, 2013

Filed:

Jun 10, 2009

Appl. No.:

12/482426

Inventors:

Carl F. Ware - Solana Beach CA, US
Carl De Trez - Brussels, BE
Michael Croft - San Diego CA, US
Timothy C. Cheung - Sydney, AU
Ian R. Humphreys - St. Brides Major, GB
Karen G. Potter - San Diego CA, US
Christopher A. Benedict - Encinitas CA, US
Mitchell Kronenberg - Del Mar CA, US
Marcos W. Steinberg - San Diego CA, US

Assignee:

La Jolla Institute for Allergy and Immunology - La Jolla CA

International Classification:

A61K 39/395

US Classification:

4241301

Abstract:

Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation.