Karine M Fabio

US Patent:

20120010168, Jan 12, 2012

Filed:

Nov 3, 2009

Appl. No.:

13/127284

Inventors:

Jeffrey Laskin - Piscataway NJ, US
Diane Heck - Rumson NJ, US
Karine Fabio - Bethlehem PA, US
C. Jeffrey Lacey - Bethlehem PA, US
Sherri Young - Bethlehem PA, US
Pramod Mohanta - Bethlehem PA, US
Christophe Guillon - Bethlehem PA, US
Ned Heindel - Easton PA, US

International Classification:

A61K 31/695
C07C 69/96
A61P 29/00
C07D 209/26
A61K 31/404
C07F 7/10
A61K 31/265

US Classification:

514 63, 556418, 558273, 514512, 548406, 548500, 548501, 514419

Abstract:

A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X═C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed.