Katherine J. Franz - Durham NC, US Louise K. Charkoudian - Palo Alto CA, US
Assignee:
Duke University - Durham NC
International Classification:
A61K 31/69 C07F 5/02
US Classification:
514 64, 546 13, 564 8, 549213
Abstract:
The present invention provides compounds of Formula (I): along with compositions containing the same and methods of use thereof in treating oxidative stress.
Photolabile Caged Transition Metal Complexes And Methods Of Using The Same
Katherine J. Franz - Durham NC, US Katie L. Ciesienski - Chestnut Hill MA, US
Assignee:
Duke University - Durham NC
International Classification:
A61M 37/00 C07F 1/08 A61K 31/555 A61P 35/00
US Classification:
546 6, 604 20, 514185, 4351731
Abstract:
The present invention provides compounds of Formula I: (I) along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
Prochelators For Inhibiting Metal-Promoted Oxidative Stress
Katherine J. Franz - Durham NC, US Filip Kielar - Malá Morávka, CZ
Assignee:
Duke University - Durham NC
International Classification:
A01N 55/08 A61K 31/69
US Classification:
514 64, 558288, 546 13
Abstract:
The present invention provides compounds of Formula I along with compositions containing the same and methods of use thereof in treating oxidative stress.
The present invention provides lanthanide binding tags (LBT) that selectively complex trivalent lanthanide (Ln) ions and afford stable complexes with desirable physical properties, including at least one of fluorescence and anomalous x-ray scattering.
Fluorescent Prochelators For Cellular Iron Detection
Katherine J. Franz - Durham NC, US Lynne M. Hyman - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
C12Q 1/02 C07C 241/00
US Classification:
435 29, 564148
Abstract:
Fluorescent probe compound of Formula Ia or Formula Ib:are described, along with methods of using the same to detect iron, copper, and hydrogen peroxide.
Prochelators Useful For Inhibiting Metal-Associated Toxicity
Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
Duke University
Professor of Chemistry at Duke University
Education:
Massachusetts Institute of Technology 1995 - 2000
Doctorates, Doctor of Philosophy, Chemistry
Wellesley College 1991 - 1995
Bachelors, Bachelor of Arts, Chemistry
Skills:
Uv/Vis Organic Chemistry Spectroscopy Organic Synthesis Biochemistry Chemistry Nmr Inorganic Chemistry Hplc Mass Spectrometry Protein Chemistry X Ray Crystallography
Kathryn Franz (1967-1971), Brent Aldrich (1970-1974), Kate Keniston (1993-1997), sara fisher (1990-1994), John Whiting (1987-1991), Kris Bjorkman (1976-1980)