Katherine A Henderson

US Patent:

8283448, Oct 9, 2012

Filed:

Jul 26, 2011

Appl. No.:

13/190628

Inventors:

Kevin M. Klucher - Bellevue WA, US
Wayne R. Kindsvogel - Seattle WA, US
Pallavur V. Sivakumar - Seattle WA, US
Katherine E Henderson - Seattle WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

C07K 14/00

US Classification:

530350, 424 852, 514 12, 514894

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

US Patent:

8318147, Nov 27, 2012

Filed:

Sep 6, 2011

Appl. No.:

13/225741

Inventors:

Kevin M. Klucher - Bellevue WA, US
Pallavur V Sivakumar - Seattle WA, US
Wayne R Kindsvogel - Seattle WA, US
Katherine E Henderson - Seattle WA, US

Assignee:

ZymoGenetics, Inc. - Seattle WA

International Classification:

A61K 38/19
A61K 38/21
A61K 45/00

US Classification:

424 852, 514 37

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

US Patent:

20040138122, Jul 15, 2004

Filed:

Oct 23, 2003

Appl. No.:

10/691923

Inventors:

Kevin Klucher - Bellevue WA, US
Pallavur Sivakumar - Seattle WA, US
Wayne Kindsvogel - Seattle WA, US
Katherine Henderson - Seattle WA, US

International Classification:

A61K039/29

US Classification:

514/012000, 424/189100

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

US Patent:

20050244423, Nov 3, 2005

Filed:

Apr 4, 2005

Appl. No.:

11/098662

Inventors:

Kevin Klucher - Bellevue WA, US
Wayne Kindsvogel - Seattle WA, US
Pallavur Sivakumar - Seattle WA, US
Katherine Henderson - Seattle WA, US

International Classification:

A61K039/12
A61K039/21
A61K039/29

US Classification:

424186100, 424188100, 424189100

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

US Patent:

20070015204, Jan 18, 2007

Filed:

Sep 14, 2006

Appl. No.:

11/531931

Inventors:

Kevin Klucher - Bellevue WA, US
Pallavur Sivakumar - Seattle WA, US
Wayne Kindsvogel - Seattle WA, US
Katherine Henderson - Seattle WA, US

International Classification:

C12Q 1/70
C12Q 1/68

US Classification:

435006000, 435005000

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

US Patent:

20070048262, Mar 1, 2007

Filed:

Sep 13, 2006

Appl. No.:

11/531646

Inventors:

Kevin Klucher - Bellevue WA, US
Pallavur Sivakumar - Seattle WA, US
Wayne Kindsvogel - Seattle WA, US
Katherine Henderson - Seattle WA, US

International Classification:

A61K 38/20

US Classification:

424085200

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

US Patent:

20070053874, Mar 8, 2007

Filed:

Oct 11, 2006

Appl. No.:

11/548429

Inventors:

Kevin Klucher - Bellevue WA, US
Pallavur Sivakumar - Seattle WA, US
Wayne Kindsvogel - Seattle WA, US
Katherine Henderson - Seattle WA, US

International Classification:

A61K 38/20

US Classification:

424085200

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.

US Patent:

20070065401, Mar 22, 2007

Filed:

Oct 11, 2006

Appl. No.:

11/548422

Inventors:

Kevin Klucher - Bellevue WA, US
Wayne Kindsvogel - Seattle WA, US
Katherine Henderson - Seattle WA, US

International Classification:

A61K 38/20

US Classification:

424085200

Abstract:

IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.