Katherine Lynette Jones

US Patent:

8372819, Feb 12, 2013

Filed:

Apr 1, 2011

Appl. No.:

13/078813

Inventors:

Katherine Jones - Solana Beach CA, US
Lirong Zhang - San Diego CA, US
Vanessa Bres - San Diego CA, US
Yupeng Chen - San Diego CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 48/00

US Classification:

514 44, 536 245, 536 2431, 536 241

Abstract:

Provided herein are methods and compositions for modulating apoptosis by targeting SKIP (Ski-interacting protein) activity. Methods of increasing DNA damage-induced cell death in cancer cells, and reducing DNA damage-induced cell death in normal cells are provided.

US Patent:

20100211863, Aug 19, 2010

Filed:

Feb 19, 2009

Appl. No.:

12/389303

Inventors:

Katherine Jones - Seattle WA, US
Christopher Parker - Seattle WA, US

Assignee:

MICROSOFT CORPORATION - Redmond WA

International Classification:

G06F 17/20

US Classification:

715224

Abstract:

Usage data representing users' actions with applications, client devices such as PCs, and peripheral devices like personal media players is collected from a variety of sources and utilized by an automated user profile population service to pre-populate user profile forms with suggestions for entries that can be presented to an application user when initially registering with the application or when a user profile gets updated. The user can review the suggested pre-populated entries in the user profile form and accept those that are appropriate and desired and reject those that are not.

US Patent:

20100217720, Aug 26, 2010

Filed:

Feb 20, 2009

Appl. No.:

12/390261

Inventors:

Katherine Jones - Seattle WA, US
Christopher Parker - Seattle WA, US

Assignee:

MICROSOFT CORPORATION - Redmond WA

International Classification:

G06Q 99/00

US Classification:

705319

Abstract:

Content may be effectively virally propagated using an arrangement that identifies prolific Internet users who are likely to share content more often and with more people. These users are termed “connectors” because they typically function as a common link between disparate groups and will thus be the center point of a large social graph. Connectors are valuable to identify because content that is received by them can be expected to propagate more quickly as compared with propagation by other users who are not connectors. Users of on-line applications (such as social networking applications) who have the greatest probability of being connectors are identified by the application of heuristics to data that pertains to the users.

US Patent:

20100235235, Sep 16, 2010

Filed:

Mar 10, 2009

Appl. No.:

12/400989

Inventors:

S. Farid Hosseini - Redmond WA, US
Christopher Parker - Seattle WA, US
Katherine Jones - Seattle WA, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06Q 30/00
G06F 15/16
G06Q 99/00

US Classification:

705 1449, 709206, 705 11

Abstract:

During an instant message conversation, instant message users may be presented with advertisements, news headlines, hyperlinks to web pages, and other additional information. It may be advantageous to provide targeted information that may be relevant to the current conversation between the instant message users. As provided herein, an endorsable entity may be presented to an instant message user based upon parsing an instant message from an instant message conversation. An instant message may be parsed for a proper noun (e.g., a word or grouping of words within the instant message text). The proper noun (e.g., a retail product) may be compared to an index to determine a topic of interest (e.g., a manufacturer of the particular retail product). The topic of interest may be used to determined an endorsable entity (e.g., an advertisement of the manufacturer), which may be presented to instant message users engaged in the instant message conversation.

US Patent:

62709569, Aug 7, 2001

Filed:

Jul 30, 1998

Appl. No.:

9/126980

Inventors:

Katherine A. Jones - Encinitas CA
Ping Wei - Brookeville MD
Mitchell Garber - Woodland Hills CA
Shi-Min Fang - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12Q 170
A61K 3800
C07K 100
C07K 1600

US Classification:

435 5

Abstract:

In accordance with the present invention, a host cell protein has been discovered which regulates Tat transactivation. The protein is the first discovered constituent of the TAK/TEFb complex which associates with the HIV Tat, via divalent cation metals, and is necessary for the binding of Tat to TAR RNA. This protein, cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It is further discovered that Tat must interact with TAK in order to bind to TAR RNA with affinity and with the appropriate sequence specificity that is observed in vivo. In accordance with another aspect of the invention, formulations useful for modulation of Tat transactivation have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.

US Patent:

62844563, Sep 4, 2001

Filed:

Dec 30, 1999

Appl. No.:

9/476482

Inventors:

Katherine A. Jones - Encinitas CA
Ping Wei - San Diego CA
Mitchell Garber - Woodland Hills CA
Shi-Min Fang - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12Q 170
A61K 3800
C07K 100
C07K 1600
C07H 2102

US Classification:

435 5

Abstract:

In accordance with the present invention, isolated nucleic acid encoding a host cell protein that regulates Tat transactivation has been discovered. The protein is the first discovered constituent of the TAK/TEFb complex which associates with the HIV Tat, via divalent cation metals, and is necessary for the binding of Tat to TAR RNA. This protein, cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It is further discovered that Tat must interact with TAK in order to bind to TAR RNA with affinity and with the appropriate sequence specificity that is observed in vivo. In accordance with another aspect of the invention, formulations useful for modulation of Tat transactivation have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.