Kathleen E Gabriel

US Patent:

20220340667, Oct 27, 2022

Filed:

Nov 19, 2021

Appl. No.:

17/531368

Inventors:

- Dublin 2, IE
Kathleen GABRIEL - Voorhees NJ, US
Guido MAGNI - Basel, CH
Richard WOODWARD - Phoenixville PA, US
Shao-Lee LIN - Lake Forest IL, US
Jeffrey W. SHERMAN - Lincolnshire IL, US

International Classification:

C07K 16/28
A61P 27/02
A61K 45/06
A61K 39/395
C07K 16/24
A61K 9/00
A61K 9/19
A61K 9/08
A61K 47/18
A61K 47/26

Abstract:

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

US Patent:

20220324985, Oct 13, 2022

Filed:

Nov 19, 2021

Appl. No.:

17/531365

Inventors:

- Dublin 2, IE
Kathleen GABRIEL - Voorhees NJ, US
Guido MAGNI - Basel, CH
Richard WOODWARD - Phoenixville PA, US

International Classification:

C07K 16/28
A61K 39/395
A61K 45/06
A61P 27/02

Abstract:

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

US Patent:

20210284741, Sep 16, 2021

Filed:

Dec 10, 2020

Appl. No.:

17/117625

Inventors:

- Hamilton Pembroke, BM
Kathleen GABRIEL - Voorhees NJ, US
Guido MAGNI - Basel, CH
Richard WOODWARD - Phoenixville PA, US

International Classification:

C07K 16/28
A61K 45/06

Abstract:

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.

US Patent:

20190270820, Sep 5, 2019

Filed:

Mar 5, 2019

Appl. No.:

16/293293

Inventors:

- Hamilton Pembroke, BM
Kathleen GABRIEL - Voorhees NJ, US
Guido MAGNI - Basel, CH
Richard WOODWARD - Phoenixville PA, US
Shao-Lee LIN - Lake Forest IL, US
Jeffrey W. SHERMAN - Lincolnshire IL, US

International Classification:

C07K 16/28
A61P 27/02
A61K 45/06
A61K 39/395
C07K 16/24
A61K 9/00

Abstract:

The invention provides a method of treating or reducing the severity of thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), or a symptom or aspect thereof, in subjects that have undergone prior treatment for TAO, TED, or GO, and either did not respond to said prior treatment or relapsed after said prior treatment. The invention also provides antibodies, or antigen binding fragments thereof, and pharmaceutical compositions useful in the disclosed methods.

US Patent:

20190225696, Jul 25, 2019

Filed:

Jan 24, 2019

Appl. No.:

16/256221

Inventors:

- Hamilton, BM
Kathleen GABRIEL - Voorhees NJ, US
Guido MAGNI - Basel, CH
Richard WOODWARD - Phoenixville PA, US

International Classification:

C07K 16/28
A61K 39/395
A61K 45/06
A61P 27/02

Abstract:

The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful in the methods.