Kathleen Gilbert

US Patent:

6664394, Dec 16, 2003

Filed:

Apr 12, 2002

Appl. No.:

10/122277

Inventors:

Kathleen Gilbert - Little Rock AR
E. Kim Fifer - North Little Rock AR

Assignee:

The Board of Trustees of the University of Arkansas - Little Rock AR

International Classification:

A61K 31495

US Classification:

544386, 51425501

Abstract:

The present invention provides a series of compounds having structural formulas wherein n is 1 to 5, n is 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein Râ is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, n is not 1; and wherein X and Râ are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in an individual.

US Patent:

7034020, Apr 25, 2006

Filed:

Dec 12, 2003

Appl. No.:

10/734919

Inventors:

Kathleen Gilbert - Little Rock AR, US
E. Kim Fifer - North Little Rock AR, US

Assignee:

The University of Arkansas for Medical Science - Little Rock AR

International Classification:

A61K 31/5375
C07D 295/15
A61P 43/00

US Classification:

5142378, 544105, 544172

Abstract:

The present invention provides a series of compounds having structural formulas wherein nis 1 to 5, nis 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein R′ is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, nis not 1; and wherein X and R′ are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in a n individual.

US Patent:

6407107, Jun 18, 2002

Filed:

May 26, 2000

Appl. No.:

09/579602

Inventors:

Kathleen Gilbert - Little Rock AR
E. Kim Fifer - North Little Rock AR

Assignee:

The Board of Trustees of the Unversity of Arkansas - Little Rock AR

International Classification:

A61K 315375

US Classification:

5142378, 544168

Abstract:

The present invention provides a series of compounds having structural formulas wherein n is 1 to 5, n is 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein Râ is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, n is not 1; and wherein X and Râ are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in an individual.