Kathleen J Ward

US Patent:

6963769, Nov 8, 2005

Filed:

Apr 20, 2000

Appl. No.:

09/959138

Inventors:

Robert S. Balaban - Bethesda MD, US
Kathleen M. Ward - Arlington VA, US
Anthony H. Aletras - Rockville MD, US

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

A61B005/055

US Classification:

600420, 324307, 324309, 424 93

Abstract:

A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contast agents can be used to practice the present method including, without limitation, sugars, animo acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.

US Patent:

7330748, Feb 12, 2008

Filed:

Sep 24, 2004

Appl. No.:

10/948942

Inventors:

Robert S. Balaban - Bethesda MD, US
Kathleen M. Ward - Arlington VA, US
Anthony H. Aletras - Rockville MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61B 5/055

US Classification:

600420, 424 93, 324307, 324309

Abstract:

Method for determining in vivo concentration of a metabolite that includes administering a contrast agent to a subject, allowing the contrast agent to disperse to tissue of interest, performing CEDST MRI analysis of the subject, and comparing the results to known in vitro results to determine metabolite concentration.

US Patent:

20080167549, Jul 10, 2008

Filed:

Dec 17, 2007

Appl. No.:

12/002553

Inventors:

Robert S. Balaban - Bethesda MD, US
Kathleen M. Ward - Arlington VA, US
Anthony H. Aletras - Rockville MD, US

International Classification:

A61B 5/055

US Classification:

600420

Abstract:

A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contrast agents can be used to practice the present method including, without limitation, sugars, amino acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.