Kathryn M Collins

US Patent:

20120276135, Nov 1, 2012

Filed:

Nov 17, 2010

Appl. No.:

13/510021

Inventors:

Eric H. Zanelli - Sudbury MA, US
Jeff Krieger - Newtonville MA, US
Joe Connolly - Natick MA, US
Kathryn H. Collins - Plymouth MA, US

Assignee:

Ares Trading SA - Vaud

International Classification:

A61K 39/00
G01N 27/62
C07K 14/00
C07K 14/775
C07K 14/435
A61P 37/06
C07K 16/18
C07K 14/745
C07K 1/22
C07K 1/16
A61K 39/385
G01N 33/53
C07K 14/76

US Classification:

4241931, 435 792, 436501, 435 71, 4241841, 530350, 530359, 530395, 530362, 5303871, 530384, 530413, 530412

Abstract:

There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of mixtures of peptides as a group, rather than for individual peptides with a defined amino acid sequence, are complicated by the heterogeneity of the peptides to be detected. This application provides improved methods of detecting and assessing random sequence polymer (RSP) compositions, methods for the detection and quantitation of RSP compositions, means to determine and enrich a subset of peptides in an RSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering RSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation.

US Patent:

20120282296, Nov 8, 2012

Filed:

Nov 17, 2010

Appl. No.:

13/510017

Inventors:

Eric H. Zanelli - Sudbury MA, US
Jeff Krieger - Newtonville MA, US
Joe Connolly - Natick MA, US
Kathryn H. Collins - Plymouth MA, US

Assignee:

ARES TRADING SA - Vaud

International Classification:

C40B 30/04
C40B 40/10
A61P 37/06
A61K 38/02

US Classification:

4242781, 506 9, 506 18

Abstract:

There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of directed sequence polymers (DSPs), are complicated because DSPs are complex mixtures of peptides, as opposed to individual peptides with a defined amino acid sequence. This application provides improved methods of detecting and assessing DSP compositions, methods for the detection and quantitation of DSP compositions, means to determine and enrich a subset of peptides in a DSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering DSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation.

US Patent:

20140328869, Nov 6, 2014

Filed:

May 8, 2014

Appl. No.:

14/273036

Inventors:

Eric H. Zanelli - Sudbury MA, US
Jeff Krieger - Newtonville MA, US
Joe Connolly - Natick MA, US
Kathryn H. Collins - Plymouth MA, US

Assignee:

ARES TRADING SA - Vaud

International Classification:

G01N 33/543

US Classification:

4241851, 435 792

Abstract:

There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of mixtures of peptides as a group, rather than for individual peptides with a defined amino acid sequence, are complicated by the heterogeneity of the peptides to be detected. This application provides improved methods of detecting and assessing random sequence polymer (RSP) compositions, methods for the detection and quantitation of RSP compositions, means to determine and enrich a subset of peptides in an RSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering RSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation.