Katrina W Lexa

age ~40

from San Jose, CA

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Katrina Lexa Phones & Addresses

San Jose, CA
337 S Fremont St APT 413, San Mateo, CA 94401
San Francisco, CA
Westfield, NJ
Solana Beach, CA
Ann Arbor, MI
Santa Rosa, CA
Baldwinsville, NY
1560 3Rd St APT 1303, San Francisco, CA 94158

Work

Company:

Ucsf
Sep 2011
Position:

Nih postdoctoral fellow

Education

Degree:

PhD
School / High School:

University of Michigan
2006 to 2011
Specialities:

Medicinal Chemistry

Skills

Drug Design • Computational Chemistry • Biophysics • Molecular Dynamics • Drug Discovery • Chemistry • Bioinformatics • Molecular Modeling • Medicinal Chemistry • Computational Biology • Structural Biology • Docking • Scientific Writing • Data Analysis • Homology Modeling • Statistics • Physical Chemistry • Permeability • R • Macrocycles • Admet • Python • Data Mining • Perl • Quantum Mechanics

Languages

English

Industries

Pharmaceuticals

Resumes

Senior Scientist And Pathway Lead

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Location:

337 south Fremont St, San Mateo, CA 94401

Industry:

Pharmaceuticals

Work:

UCSF since Sep 2011
NIH Postdoctoral Fellow
University of Michigan - Ann Arbor, MI Aug 2005 - Aug 2011
Graduate Student
Hamilton College May 2002 - Aug 2006
Student Researcher

Education:

University of Michigan 2006 - 2011
PhD, Medicinal Chemistry University of Michigan 2005 - 2006
Hamilton College 2001 - 2005
B.A., Chemistry, Public Policy, French (minor)

Skills:

Drug Design
Computational Chemistry
Biophysics
Molecular Dynamics
Drug Discovery
Chemistry
Bioinformatics
Molecular Modeling
Medicinal Chemistry
Computational Biology
Structural Biology
Docking
Scientific Writing
Data Analysis
Homology Modeling
Statistics
Physical Chemistry
Permeability
R
Macrocycles
Admet
Python
Data Mining
Perl
Quantum Mechanics

Languages:

English

Us Patents

Progranulin Variants
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US Patent:

20220220172, Jul 14, 2022
Filed:

Mar 18, 2022
Appl. No.:

17/698456
Inventors:

- South San Francisco CA, US
Gunasekaran Kannan - South San Francisco CA, US
Katrina W. Lexa - South San Francisco CA, US
Ray L.Y. Low - South San Francisco CA, US
Rachel Prorok - South San Francisco CA, US
Ankita Srivastava - South San Francisco CA, US
Assignee:

Denali Therapeutics Inc. - South San Francisco CA
International Classification:

C07K 14/475
A61P 25/28
Abstract:

Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.

Progranulin Variants
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US Patent:

20220213155, Jul 7, 2022
Filed:

Mar 17, 2022
Appl. No.:

17/697771
Inventors:

- South San Francisco CA, US
Gunasekaran Kannan - South San Francisco CA, US
Katrina W. Lexa - South San Francisco CA, US
Ray L.Y. Low - South San Francisco CA, US
Rachel Prorok - South San Francisco CA, US
Ankita Srivastava - South San Francisco CA, US
Assignee:

Denali Therapeutics Inc. - South San Francisco CA
International Classification:

C07K 14/475
A61P 25/28
Abstract:

Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.

Compounds, Compositions And Methods
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US Patent:

20220177456, Jun 9, 2022
Filed:

Mar 6, 2020
Appl. No.:

17/436297
Inventors:

- South San Francisco CA, US
Javier de Vicente Fidalgo - Foster City CA, US
Anthony A. Estrada - Danville CA, US
Jianwen A. Feng - San Mateo CA, US
Katrina W. Lexa - San Francisco CA, US
Maksim Osipov - Redwood City CA, US
Zachary K. Sweeney - Redwood City CA, US
Arun Thottumkara - San Francisco CA, US
International Classification:

C07D 405/06
C07D 309/14
C07D 405/12
C07D 471/04
C07D 405/04
Abstract:

The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Compounds, Compositions And Methods
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US Patent:

20210147435, May 20, 2021
Filed:

Aug 8, 2018
Appl. No.:

16/637718
Inventors:

- South San Francisco CA, US
Javier de Vicente Fidalgo - Foster City CA, US
Anthony A. Estrada - San Mateo CA, US
Jianwen A. Feng - San Mateo CA, US
Brian M. Fox - Brisbane CA, US
Christopher R.H. Hale - South San Francisco CA, US
Katrina W. Lexa - San Francisco CA, US
Maksim Osipov - Redwood City CA, US
Travis Remarchuk - South San Francisco CA, US
Zachary K. Sweeney - Redwood City CA, US
International Classification:

C07D 491/048
C07D 413/04
C07D 271/10
C07D 249/04
C07D 261/04
C07D 261/08
C07D 263/32
C07C 235/22
C07D 249/08
C07D 233/61
C07D 413/12
C07D 487/04
C07D 471/04
C07D 413/06
C07D 403/12
C07D 401/12
C07D 271/06
C07D 263/38
C07D 207/27
C07D 233/42
C07D 233/36
C07D 403/04
C07D 263/56
C07D 233/64
C07D 257/04
C07D 417/04
C07D 291/04
Abstract:

The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.

Modulators Of Eukaryotic Initiation Factor 2
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US Patent:

20210130308, May 6, 2021
Filed:

Mar 22, 2019
Appl. No.:

16/982471
Inventors:

- South San Francisco CA, US
Javier de Vicente Fidalgo - Foster City CA, US
Anthony A. Estrada - Danville CA, US
Jianwen A. Feng - San Mateo CA, US
Brian M. Fox - Redwood City CA, US
Katrina W. Lexa - San Francisco CA, US
Maksim Osipov - Redwood City CA, US
Zachary K. Sweeney - Redwood City CA, US
Arun Thottumkara - Woodside CA, US
International Classification:

C07D 271/07
C07D 211/58
C07D 221/20
C07D 209/52
C07D 205/12
C07D 205/04
C07D 413/04
C07D 233/32
C07D 401/04
C07C 235/22
C07C 255/46
Abstract:

The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.

Penicillin-G Acylases
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US Patent:

20210054357, Feb 25, 2021
Filed:

Nov 6, 2020
Appl. No.:

17/091479
Inventors:

- Redwood City CA, US
David Elgart - San Mateo CA, US
Robert Kevin Orr - Cranford NJ, US
James Nicholas Riggins - San Francisco CA, US
Anna Fryszkowska - New York NY, US
Katrina W. Lexa - Santa Rosa CA, US
Xiang Yi - San Carlos CA, US
Da Duan - Newark CA, US
Courtney Dianne Moffett - San Francisco CA, US
Nikki Dellas - San Carlos CA, US
Vesna Mitchell - Santa Clara CA, US
International Classification:

C12N 9/84
C07K 14/62
C12P 21/02
Abstract:

The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Penicillin-G Acylases
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US Patent:

20200339972, Oct 29, 2020
Filed:

Jun 15, 2020
Appl. No.:

16/902001
Inventors:

- Redwood City CA, US
Vesna Mitchell - Santa Clara CA, US
David Elgart - San Mateo CA, US
Katrina W. Lexa - Santa Rosa CA, US
Nikki Dellas - Mountain View CA, US
Robert Kevin Orr - Cranford NJ, US
Oscar Alvizo - Fremont CA, US
Ravi David Garcia - Los Gatos CA, US
Judy Victoria Antonio Viduya - South San Francisco CA, US
Courtney Dianne Moffett - San Francisco CA, US
International Classification:

C12N 9/84
C07K 14/62
C12P 21/02
Abstract:

The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Penicillin-G Acylases
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US Patent:

20200339973, Oct 29, 2020
Filed:

Jul 13, 2020
Appl. No.:

16/927129
Inventors:

- Redwood City CA, US
David Elgart - San Mateo CA, US
Robert Kevin Orr - Cranford NJ, US
James Nicholas Riggins - San Francisco CA, US
Anna Fryszkowska - New York NY, US
Katrina W. Lexa - Santa Rosa CA, US
Xiang Yi - Foster City CA, US
Da Duan - Newark CA, US
Courtney Dianne Moffett - San Francisco CA, US
Nikki Dellas - Mountain View CA, US
Vesna Mitchell - Santa Clara CA, US
International Classification:

C12N 9/84
C07K 14/62
C12P 21/02
Abstract:

The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.