Katrina W Lexa from San Jose, CA, age 41

Resumes

Senior Scientist And Pathway Lead

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Location:

337 south Fremont St, San Mateo, CA 94401

Industry:

Pharmaceuticals

Work:

UCSF since Sep 2011
NIH Postdoctoral Fellow
University of Michigan - Ann Arbor, MI Aug 2005 - Aug 2011
Graduate Student
Hamilton College May 2002 - Aug 2006
Student Researcher

Education:

University of Michigan 2006 - 2011
PhD, Medicinal Chemistry University of Michigan 2005 - 2006
Hamilton College 2001 - 2005
B.A., Chemistry, Public Policy, French (minor)

Skills:

Drug Design
Computational Chemistry
Biophysics
Molecular Dynamics
Drug Discovery
Chemistry
Bioinformatics
Molecular Modeling
Medicinal Chemistry
Computational Biology
Structural Biology
Docking
Scientific Writing
Data Analysis
Homology Modeling
Statistics
Physical Chemistry
Permeability
R
Macrocycles
Admet
Python
Data Mining
Perl
Quantum Mechanics

Languages:

English

Us Patents

Progranulin Variants
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US Patent:

20220220172, Jul 14, 2022
Filed:

Mar 18, 2022
Appl. No.:

17/698456
Inventors:

- South San Francisco CA, US
Gunasekaran Kannan - South San Francisco CA, US
Katrina W. Lexa - South San Francisco CA, US
Ray L.Y. Low - South San Francisco CA, US
Rachel Prorok - South San Francisco CA, US
Ankita Srivastava - South San Francisco CA, US
Assignee:

Denali Therapeutics Inc. - South San Francisco CA
International Classification:

C07K 14/475
A61P 25/28
Abstract:

Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.

Progranulin Variants
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US Patent:

20220213155, Jul 7, 2022
Filed:

Mar 17, 2022
Appl. No.:

17/697771
Inventors:

- South San Francisco CA, US
Gunasekaran Kannan - South San Francisco CA, US
Katrina W. Lexa - South San Francisco CA, US
Ray L.Y. Low - South San Francisco CA, US
Rachel Prorok - South San Francisco CA, US
Ankita Srivastava - South San Francisco CA, US
Assignee:

Denali Therapeutics Inc. - South San Francisco CA
International Classification:

C07K 14/475
A61P 25/28
Abstract:

Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.

Compounds, Compositions And Methods
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US Patent:

20220177456, Jun 9, 2022
Filed:

Mar 6, 2020
Appl. No.:

17/436297
Inventors:

- South San Francisco CA, US
Javier de Vicente Fidalgo - Foster City CA, US
Anthony A. Estrada - Danville CA, US
Jianwen A. Feng - San Mateo CA, US
Katrina W. Lexa - San Francisco CA, US
Maksim Osipov - Redwood City CA, US
Zachary K. Sweeney - Redwood City CA, US
Arun Thottumkara - San Francisco CA, US
International Classification:

C07D 405/06
C07D 309/14
C07D 405/12
C07D 471/04
C07D 405/04
Abstract:

The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

Compounds, Compositions And Methods
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US Patent:

20210147435, May 20, 2021
Filed:

Aug 8, 2018
Appl. No.:

16/637718
Inventors:

- South San Francisco CA, US
Javier de Vicente Fidalgo - Foster City CA, US
Anthony A. Estrada - San Mateo CA, US
Jianwen A. Feng - San Mateo CA, US
Brian M. Fox - Brisbane CA, US
Christopher R.H. Hale - South San Francisco CA, US
Katrina W. Lexa - San Francisco CA, US
Maksim Osipov - Redwood City CA, US
Travis Remarchuk - South San Francisco CA, US
Zachary K. Sweeney - Redwood City CA, US
International Classification:

C07D 491/048
C07D 413/04
C07D 271/10
C07D 249/04
C07D 261/04
C07D 261/08
C07D 263/32
C07C 235/22
C07D 249/08
C07D 233/61
C07D 413/12
C07D 487/04
C07D 471/04
C07D 413/06
C07D 403/12
C07D 401/12
C07D 271/06
C07D 263/38
C07D 207/27
C07D 233/42
C07D 233/36
C07D 403/04
C07D 263/56
C07D 233/64
C07D 257/04
C07D 417/04
C07D 291/04
Abstract:

The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.

Modulators Of Eukaryotic Initiation Factor 2
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US Patent:

20210130308, May 6, 2021
Filed:

Mar 22, 2019
Appl. No.:

16/982471
Inventors:

- South San Francisco CA, US
Javier de Vicente Fidalgo - Foster City CA, US
Anthony A. Estrada - Danville CA, US
Jianwen A. Feng - San Mateo CA, US
Brian M. Fox - Redwood City CA, US
Katrina W. Lexa - San Francisco CA, US
Maksim Osipov - Redwood City CA, US
Zachary K. Sweeney - Redwood City CA, US
Arun Thottumkara - Woodside CA, US
International Classification:

C07D 271/07
C07D 211/58
C07D 221/20
C07D 209/52
C07D 205/12
C07D 205/04
C07D 413/04
C07D 233/32
C07D 401/04
C07C 235/22
C07C 255/46
Abstract:

The present disclosure relates generally to eukaryotic initiation factor 2B modulators of formula A, or a pharmaceutically acceptable salt, stereoisomer, or mixture of stereoisomers thereof and methods of making and using thereof.

Penicillin-G Acylases
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US Patent:

20210054357, Feb 25, 2021
Filed:

Nov 6, 2020
Appl. No.:

17/091479
Inventors:

- Redwood City CA, US
David Elgart - San Mateo CA, US
Robert Kevin Orr - Cranford NJ, US
James Nicholas Riggins - San Francisco CA, US
Anna Fryszkowska - New York NY, US
Katrina W. Lexa - Santa Rosa CA, US
Xiang Yi - San Carlos CA, US
Da Duan - Newark CA, US
Courtney Dianne Moffett - San Francisco CA, US
Nikki Dellas - San Carlos CA, US
Vesna Mitchell - Santa Clara CA, US
International Classification:

C12N 9/84
C07K 14/62
C12P 21/02
Abstract:

The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Penicillin-G Acylases
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US Patent:

20200339972, Oct 29, 2020
Filed:

Jun 15, 2020
Appl. No.:

16/902001
Inventors:

- Redwood City CA, US
Vesna Mitchell - Santa Clara CA, US
David Elgart - San Mateo CA, US
Katrina W. Lexa - Santa Rosa CA, US
Nikki Dellas - Mountain View CA, US
Robert Kevin Orr - Cranford NJ, US
Oscar Alvizo - Fremont CA, US
Ravi David Garcia - Los Gatos CA, US
Judy Victoria Antonio Viduya - South San Francisco CA, US
Courtney Dianne Moffett - San Francisco CA, US
International Classification:

C12N 9/84
C07K 14/62
C12P 21/02
Abstract:

The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Penicillin-G Acylases
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US Patent:

20200339973, Oct 29, 2020
Filed:

Jul 13, 2020
Appl. No.:

16/927129
Inventors:

- Redwood City CA, US
David Elgart - San Mateo CA, US
Robert Kevin Orr - Cranford NJ, US
James Nicholas Riggins - San Francisco CA, US
Anna Fryszkowska - New York NY, US
Katrina W. Lexa - Santa Rosa CA, US
Xiang Yi - Foster City CA, US
Da Duan - Newark CA, US
Courtney Dianne Moffett - San Francisco CA, US
Nikki Dellas - Mountain View CA, US
Vesna Mitchell - Santa Clara CA, US
International Classification:

C12N 9/84
C07K 14/62
C12P 21/02
Abstract:

The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.