Ke Yu Yang

US Patent:

6630589, Oct 7, 2003

Filed:

Mar 26, 2002

Appl. No.:

10/106572

Inventors:

Anthony Giordano - Phoenixville PA
Gordon Donald Powers - Malvern PA
Michael Alan Sturgess - Perkasie PA
Ke Yang - Boothwyn PA

Assignee:

Message Pharmaceuticals - Malvern PA

International Classification:

C07D40102

US Classification:

546139, 548566, 5462764, 560 21, 564 50

Abstract:

The invention features screening assays for compounds that are potentially useful for treating or preventing a proliferative disease. The assays are based on contacting a candidate compound with a cell containing a nucleic acid including a HER2 regulatory element and a reporter sequence. In addition, the invention features compounds identified by the assays of the invention. The invention further features compounds structurally related to those identified by the screening assays. Finally, the invention features methods of treating or preventing a proliferative disease using the compounds of the invention.

US Patent:

20030232801, Dec 18, 2003

Filed:

Apr 15, 2003

Appl. No.:

10/413910

Inventors:

Michael Sturgess - Perkasie PA, US
Ke Yang - Boothwyn PA, US

International Classification:

A61K031/397
A61K031/445
A61K031/40
A61K031/325
C07D211/08
C 07D 2 7/08
C 07D 2 5/04
A61K031/17

US Classification:

514/210010, 514/318000, 514/423000, 514/485000, 514/597000, 546/206000, 548/557000, 548/950000, 552/297000

Abstract:

The invention features compounds for the treatment of cancer and other proliferative diseases. These compounds were identified in screening assays that contact candidate compounds with a cell containing a nucleic acid that includes a HER2 regulatory element and a reporter sequence. The invention further features compounds structurally related to those identified by the screening assays. Finally, the invention features methods of treating or preventing a proliferative disease using the compounds of the invention.

US Patent:

20170145825, May 25, 2017

Filed:

Nov 18, 2016

Appl. No.:

15/355861

Inventors:

- New Brunswick NJ, US
Ke Yang - Parlin NJ, US
Xiangyu Gong - Edison NJ, US

International Classification:

F01B 19/04
F15B 15/10

Abstract:

A rotary actuator and a method of using same are disclosed. The rotary actuator includes a rotor having a body and defining a plurality of contact surfaces, and a stator having a body and defining a plurality of inflatable bladders circumferentially spaced about the stator body. The stator is positioned relative to the rotor such that upon sequential inflation of the plurality of inflatable bladders, the rotor is caused to rotate.