Ke E Yang

US Patent:

6630589, Oct 7, 2003

Filed:

Mar 26, 2002

Appl. No.:

10/106572

Inventors:

Anthony Giordano - Phoenixville PA
Gordon Donald Powers - Malvern PA
Michael Alan Sturgess - Perkasie PA
Ke Yang - Boothwyn PA

Assignee:

Message Pharmaceuticals - Malvern PA

International Classification:

C07D40102

US Classification:

546139, 548566, 5462764, 560 21, 564 50

Abstract:

The invention features screening assays for compounds that are potentially useful for treating or preventing a proliferative disease. The assays are based on contacting a candidate compound with a cell containing a nucleic acid including a HER2 regulatory element and a reporter sequence. In addition, the invention features compounds identified by the assays of the invention. The invention further features compounds structurally related to those identified by the screening assays. Finally, the invention features methods of treating or preventing a proliferative disease using the compounds of the invention.

US Patent:

20030232801, Dec 18, 2003

Filed:

Apr 15, 2003

Appl. No.:

10/413910

Inventors:

Michael Sturgess - Perkasie PA, US
Ke Yang - Boothwyn PA, US

International Classification:

A61K031/397
A61K031/445
A61K031/40
A61K031/325
C07D211/08
C 07D 2 7/08
C 07D 2 5/04
A61K031/17

US Classification:

514/210010, 514/318000, 514/423000, 514/485000, 514/597000, 546/206000, 548/557000, 548/950000, 552/297000

Abstract:

The invention features compounds for the treatment of cancer and other proliferative diseases. These compounds were identified in screening assays that contact candidate compounds with a cell containing a nucleic acid that includes a HER2 regulatory element and a reporter sequence. The invention further features compounds structurally related to those identified by the screening assays. Finally, the invention features methods of treating or preventing a proliferative disease using the compounds of the invention.

US Patent:

48852384, Dec 5, 1989

Filed:

Oct 30, 1987

Appl. No.:

7/114508

Inventors:

Roger R. Reddel - Kensington MD
Ke Yang - Bethesda MD
Johng S. Rhim - Bethesda MD
Douglas Brash - Washington DC
Robert T. Su - Lawrence KS
John F. Lechner - Kensington MD
Brenda I. Gerwin - Bethesda MD
Curtis C. Harris - Bethesda MD
Paul Amstad - Epolinges, CH

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12Q 118
C12Q 102
C12Q 168
C12N 1500

US Classification:

435 29

Abstract:

Immortalized human bronchial epithelial and human mesothelial cell lines have been obtained. Various uses of these cell lines have been described.