Keith R James

US Patent:

49754440, Dec 4, 1990

Filed:

Aug 25, 1989

Appl. No.:

7/398675

Inventors:

John C. Danilewicz - New York NY
Keith James - New York NY
Ryszard J. Kobylecki - New York NY

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 31195
A61K 3124
C07C22910

US Classification:

514354

Abstract:

Compounds of the formula ##STR1## wherein A is a carbocyclic, saturated or unsaturated ring; R. sup. 1 is hydrogen or alkyl; R and R. sup. 4 are each alkyl, cycloalkyl, benzyl or a readily hydrolyzable ester group; Y is a bond or a straight or branch alkylene; R. sup. 2 is hydrogen, aryl, heterocyclic, R. sup. 6 CONR. sup. 5, R. sup. 7 NR. sup. 5 CO, R. sup. 7 NR. sup. 5 SO. sub. 2 --or R. sup. 8 SO. sub. 2 NR. sup. 5 --where R. sup. 5 is hydrogen, alkyl or aralkyl; R. sup. 6 is alkyl, aryl, aralkyl, heterocyclic, heterocyclyalkyl or a group of the formula ##STR2## where R. sup. 9 is hydrogen, hydroxy, alkoxy, alkyl, hydroxyalkyl, aralkyl, alkylene, heterocyclic, heterocyclylalkyl, R. sup. 12 CONH--, R. sup. 12 SO. sub. 2 NH-- or (R. sup. 13). sub. 2 N--; R. sup. 10 and R. sup.