Kenneth Houlton Duncan

US Patent:

8404692, Mar 26, 2013

Filed:

Oct 9, 2006

Appl. No.:

12/083534

Inventors:

Stuart Jones - Dundee, GB
Robert Westwood - Oxon, GB
Mark Thomas - Dundee, GB
Janice McLachlan - Dundee, GB
Kenneth Duncan - Waltham MA, US
Fred Scaerou - Cambridge, GB
Daniella I. Zheleva - Fife, GB

Assignee:

Cyclacel Limited - London

International Classification:

A61K 31/4965

US Classification:

51425505, 514275, 5142521, 514249, 514248, 514247, 544295, 544242, 544349, 544338

Abstract:

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts thereof, wherein Z is NR, NHCO, NHSO, NHCH, CH, CHCH, or CH═CH; X is a hydrocarbyl group optionally substituted by one or more Rgroups; Rand Rare each independently II or alkyl; R-Rare each independently II or (CII)R, where m is O, 1, 2, or 3; each Ris independently (CH)R, where each Ris independently selected from O(CH)R, R, COR, COOR, CN, CONRR, NRR, NRCOR, SR, SOR, SOR, NRSOR, SOOR, SONRR, halogen, CF, and NO, and wherein each a is 0, 1, 2, or 3 and b is 0, 1, 2, or 3; Rand Rare each independently H or (CH)R, where n is 0, 1, 2, or 3; and each Ris independently selected from alkyl, cycloalkyl, heteroaryl, aralkyl, aryl and heterocycloalkyl, each of which may be optionally substituted by one or more substituents selected from halogen, OH, CN, COO-alkyl, aralkyl, SO-alkyl, SO-aryl, COOH, CO-alkyl, CO-aryl, NH, NH-alkyl, N(alkyl), CF, alkyl and alkoxy, wherein said alkyl and alkoxy groups may be further substituted by one or more OH groups. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula I, and the use of compounds of formula (I) in the preparation of a medicament for treating a variety of disorders, including proliferative disorders, viral disorders, stroke, etc.

US Patent:

8410088, Apr 2, 2013

Filed:

Apr 13, 2012

Appl. No.:

13/447007

Inventors:

Kevin W. Kuntz - Woburn MA, US
Richard Chesworth - Concord MA, US
Kenneth W. Duncan - Norwood MA, US
Masashi Seki - Tsukuba, JP
Syuji Shirotori - Tsukuba, JP

Assignee:

Epizyme, Inc. - Cambridge MA
Eisai R&D Management Co., Ltd. - Tokyo

International Classification:

C07D 211/76
C07D 413/10
C07D 413/12
A61K 31/4412

US Classification:

51421115, 514218, 5142355, 51425311, 51425312, 514318, 514336, 514343, 514351, 540544, 540575, 544131, 544364, 546194, 5462764, 5462821, 546300

Abstract:

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

US Patent:

8598167, Dec 3, 2013

Filed:

Jul 9, 2013

Appl. No.:

13/938067

Inventors:

Edward James Olhava - Newton MA, US
Richard Chesworth - Concord MA, US
Kenneth William Duncan - Norwood MA, US

Assignee:

Epizyme, Inc. - Cambridge MA

International Classification:

C07D 471/04
A61K 31/4738
A61P 35/00

US Classification:

5142345, 51421021, 514293, 514303, 5142342, 514287, 546 82, 546119, 546 64, 544127

Abstract:

The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.

US Patent:

20090137572, May 28, 2009

Filed:

May 26, 2005

Appl. No.:

11/596740

Inventors:

Shudong Wang - Nottingham, GB
Gavin Wood - Cupar Fife, GB
Kenneth Duncan - Waltham MA, US
Christopher Meades - Dundee, GB
Darren Gibson - Dundee, GB
Janice McLachlan - Dundee, GB
Peter Martin Fischer - Nottingham, GB

International Classification:

A61K 31/541
C07D 417/14
A61K 31/5377
C12Q 1/48
G01N 33/53
C12N 9/99
A61P 35/00

US Classification:

5142278, 544122, 5142358, 544 60, 435184, 435 15, 435 78

Abstract:

The present invention relates to selected substituted pyrimidines their preparation, pharmaceutical compositions containing them and their use as inhibitors of one or more protein kinases, and hence their use in the treatment of proliferative disorders, viral disorders and/or other disorders.

US Patent:

20090215805, Aug 27, 2009

Filed:

Oct 9, 2006

Appl. No.:

12/083559

Inventors:

Gavin Wood - Cupar Fife, GB
Christopher Meades - Dundee, GB
Peter Martin Fischer - Nottingham, GB
Shudong Wang - Nottingham, GB
Kenneth Duncan - Waltham MA, US
Daniella I. Zheleva - Fife, GB
Campbell Mcinnes - Irmo SC, US
Mark Thomas - Dundee, GB

Assignee:

Cyclacel Limited - Dundee

International Classification:

A61K 31/506
C07D 239/02
G01N 33/566
G01N 33/53
A61P 25/28
A61P 3/10
A61P 35/00

US Classification:

514275, 544297, 436501, 435 71

Abstract:

The present invention relates to compounds of formula (I) or formula (II), or pharmaceutically acceptable salts thereof. Further aspects relate to pharmaceutical compositions comprising compounds according to the invention, and the use of said compounds in the preparation of a medicament for treating a variety of disorders, including proliferative disorders, viral disorders, stroke, etc.

US Patent:

20100292231, Nov 18, 2010

Filed:

Feb 2, 2010

Appl. No.:

12/698597

Inventors:

Alfred M. Ajami - Brookline MA, US
Kenneth Duncan - Waltham MA, US

International Classification:

A61K 31/5377
C07D 471/16
A61K 31/4745
C07D 413/14
C07D 401/14
A61K 31/497
A61P 35/00
A61P 29/00
A61P 11/00
A61P 17/06
A61P 31/18

US Classification:

5142332, 546 48, 514283, 544125, 544361, 51425302

Abstract:

Compounds of formula (I) or formula (Ia) and a method of treating a patient suffering from certain inflammatory disorders, demyelinating disorders, FLT3-mediated disorders, CSF-1R-mediated disorders, cancers and leukemias, comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or formula (Ia) or a pharmaceutically acceptable salt thereof.Definitions for the variables are provided herein.

US Patent:

20130123234, May 16, 2013

Filed:

Dec 20, 2012

Appl. No.:

13/722807

Inventors:

EISAI R&D MANAGEMENT CO., LTD. - Tokyo, JP
Kenneth William Duncan - Norwood MA, US
Heike Keilhack - Belmont MA, US
Natalie Warholic - Brighton MA, US
Christine Klaus - Weymouth MA, US
Sarah Kathleen Knutson - Cambridge MA, US
Timothy James Nelson Wigle - Waltham MA, US
Masashi Seki - Tsukuba-shi, JP
Syuji Shirotori - Tsukuba-shi, JP
Satoshi Kawano - Tsukuba-shi, JP

Assignee:

EISAI R&D MANAGEMENT CO., LTD. - Tokyo
EPIZYME, INC. - Cambridge MA

International Classification:

C07D 213/64
C07D 401/12
C07D 491/08
C07D 417/12
C07D 491/107
C07D 405/14
C07D 409/12

US Classification:

51421018, 544131, 5142355, 544364, 51425311, 546194, 514318, 546300, 514351, 5462681, 5462727, 514341, 544405, 51425505, 540575, 514218, 5142102

Abstract:

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

US Patent:

20140057891, Feb 27, 2014

Filed:

Nov 4, 2013

Appl. No.:

14/070675

Inventors:

Edward James Olhava - Newton MA, US
Richard Chesworth - Concord MA, US
Kenneth William Duncan - Norwood MA, US

Assignee:

Epizyme, Inc. - Cambridge MA

International Classification:

C07D 471/04
C07D 401/14
C07D 405/14
C07D 401/12

US Classification:

51421018, 5142342, 5142345, 51425304, 51425309, 514275, 514303, 514318, 514338, 544127, 544131, 544331, 544362, 544364, 546120, 546194, 5462757

Abstract:

The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Address:

2626 77 St, Lubbock, TX 79423

Phone:

(806)7453699

VIN:

1GNFK13067R110196

Make:

CHEVROLET

Model:

TAHOE

Year:

2007