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Kenneth B Marcu

age ~72

from Stony Brook, NY

Also known as:
  • Kenneth Marcu
  • Kenneth Dr Marcu
  • Kenneth Marco
Phone and address:
5 Dale Rd, Stonybrook, NY 11790
(631)6893293

Kenneth Marcu Phones & Addresses

  • 5 Dale Rd, Stony Brook, NY 11790 • (631)6893293
  • Stonybrook, NY
  • 6 Hunters Ct, East Setauket, NY 11733 • (631)7515734
  • Setauket, NY

Us Patents

  • Y2H14 An Ikk Binding Protein

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  • US Patent:
    6365722, Apr 2, 2002
  • Filed:
    Nov 17, 1998
  • Appl. No.:
    09/195188
  • Inventors:
    Kenneth B. Marcu - Stony Brook NY
  • Assignee:
    The Research of State University of New York - Albany NY
  • International Classification:
    C07H 2102
  • US Classification:
    536 231, 530350
  • Abstract:
    The present invention provides an isolated I B kinase binding protein designated Y2H14 and functional equivalents therof. The amino acid sequence of Y2H14, the nucleotide sequence encoding Y2H14, and other related protein and nucleic acid molecules are also provided.
  • Biologically Active Alternative Form Of The Ikk I B Kinase

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  • US Patent:
    6489151, Dec 3, 2002
  • Filed:
    Mar 27, 2000
  • Appl. No.:
    09/536882
  • Inventors:
    Kenneth B. Marcu - Stony Brook NY
    Margery A. Connelly - Medford NY
  • Assignee:
    The Research Foundation of State University of New York - Stony Brook NY
  • International Classification:
    C12N 912
  • US Classification:
    435194, 536 232
  • Abstract:
    The present invention provides isolated I B kinases that regulate NF B gene transcription that lack both a leucine zipper like -helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
  • Biologically Active Alternative Form Of The Ikk I B Kinase

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  • US Patent:
    6803204, Oct 12, 2004
  • Filed:
    Jul 3, 2002
  • Appl. No.:
    10/188937
  • Inventors:
    Kenneth B. Marcu - Stony Brook NY
    Margery A. Connelly - Medford NY
  • Assignee:
    The Research Foundation of State University of New York - Stony Brook NY
  • International Classification:
    C12Q 148
  • US Classification:
    435 15, 435194
  • Abstract:
    The present invention provides isolated I B kinases that regulate NF B gene transcription that lack both a leucine zipper like -helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
  • Methods For Modulating Ikkα Activity

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  • US Patent:
    7838268, Nov 23, 2010
  • Filed:
    Apr 26, 2007
  • Appl. No.:
    11/740438
  • Inventors:
    Jun Li - Danbury CT, US
    Xiang Li - Danbury CT, US
    Jianfei Yang - Sandy Hook CT, US
    Kenneth Marcu - Stony Brook NY, US
  • Assignee:
    Boehringer Ingelheim International GmbH - Ingelheim am Rhein
  • International Classification:
    C12Q 1/68
    C12P 19/34
    C12N 5/00
    C12N 5/02
    C07H 21/04
  • US Classification:
    435 911, 435 6, 435325, 435375, 536 245
  • Abstract:
    A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.
  • Methods For Modulating Ikkα Activity

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  • US Patent:
    8088915, Jan 3, 2012
  • Filed:
    Oct 13, 2010
  • Appl. No.:
    12/903600
  • Inventors:
    Jun Li - Danbury CT, US
    Xiang Li - Danbury CT, US
    Jianfei Yang - Sandy Hook CT, US
    Kenneth B. Marcu - Stony Brook NY, US
  • Assignee:
    Boehringer Ingelheim Pharmaceuticals Inc. - Ridgefield CT
  • International Classification:
    C07H 21/02
    C07H 21/04
  • US Classification:
    536 245, 536 231, 536 243, 536 2433
  • Abstract:
    A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.
  • Methods For The Identification Of Ikkalpha Function And Other Genes Useful For Treatment Of Imflammatory Diseases

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  • US Patent:
    20040014111, Jan 22, 2004
  • Filed:
    May 23, 2003
  • Appl. No.:
    10/446045
  • Inventors:
    Jun Li - Danbury CT, US
    Adedayo Hanidu - Bethel CT, US
    Xiang Li - Danbury CT, US
    Gregory Peet - Sherman CT, US
    Sheenah Mische - Ridgefield CT, US
    Kenneth Marcu - Stony Brook NY, US
  • International Classification:
    C12Q001/68
  • US Classification:
    435/006000
  • Abstract:
    The invention provides a method for identifying genes involved in the NF- B pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from the cells having deficient levels of a component of the NF- B pathway; determining the level of expression of said gene in a control sample obtained from wild type cells having levels of a component of a biological pathway; selecting genes having a level of expression that are modulated in said experimental sample relative to said wild type sample. The invention also provides a method of treating inflammatory related diseases by modulating the activity of IKK.
  • Methods For Modulating Ikkalpha Activity

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  • US Patent:
    20050043257, Feb 24, 2005
  • Filed:
    Dec 8, 2003
  • Appl. No.:
    10/730614
  • Inventors:
    Jun Li - Danbury CT, US
    Xiang Li - Danbury CT, US
    Jianfei Yang - Hamden CT, US
    Kenneth Marcu - Stony Brook NY, US
  • International Classification:
    A61K048/00
  • US Classification:
    514044000
  • Abstract:
    A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.
  • Methods For The Identification Of Ikkalpha Function And Other Genes Useful For Treatment Of Inflammatory Diseases

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  • US Patent:
    20070128648, Jun 7, 2007
  • Filed:
    Jan 8, 2007
  • Appl. No.:
    11/621029
  • Inventors:
    Jun Li - Danbury CT, US
    Adedeyo Hanidu - Bethel CT, US
    Xiang Li - Danbury CT, US
    Gregory Peet - Sherman CT, US
    Sheenah Mische - Ridgefield CT, US
    Kenneth Marcu - Stony Brook NY, US
  • International Classification:
    A61K 38/55
    C12Q 1/68
  • US Classification:
    435006000, 514002000
  • Abstract:
    The invention provides a method for identifying genes involved in the NF-κB pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from the cells having deficient levels of a component of the NF-κB pathway; determining the level of expression of said gene in a control sample obtained from wild type cells having levels of a component of a biological pathway; selecting genes having a level of expression that are modulated in said experimental sample relative to said wild type sample. The invention also provides a method of treating inflammatory related diseases by modulating the activity of IKKα.

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