Peter D. Williams - Harleysville PA Michelle A. Sparks - Gwynedd Valley PA Ian Bell - Harleysville PA Debra S. Perlow - East Greenville PA Kenneth Stauffer - Pottstown PA Roger M. Freidinger - Lansdale PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31535 A61K 3147 C07D26512 C07D21516
US Classification:
5142305
Abstract:
This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
Thomas Kremhelmer Thomas Kremhelmer (1947-1951), Mark Holt (1980-1986), Kevin Ruane (1972-1973), Kenneth Stauffer (1979-1986), Amanda Schroeder (1990-1995)