Kenneth R Stauffer

US Patent:

6515011, Feb 4, 2003

Filed:

Dec 18, 2001

Appl. No.:

10/023776

Inventors:

Harold G. Selnick - Ambler PA
James C. Barrow - Harleysville PA
Philippe G. Nantermet - Lansdale PA
Peter D. Williams - Harleysville PA
Kenneth J. Stauffer - Souderton PA
Philip E. Sanderson - Philadelphia PA
Kenneth E. Rittle - Green Lane PA
Matthew M. Morrissette - Pottstown PA
Catherine M. Wiscount - Allentown PA
Lekhanh O. Tran - Norristown PA
Terry A. Lyle - Lederach PA
Donnette D. Staas - Harleysville PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3140

US Classification:

514423, 548538, 548528, 548518, 546111, 5462791, 514422, 514343, 514290

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. where R is âCH NH , âCH CH NH , or âCH NHC(O)OC(CH ).

US Patent:

7144899, Dec 5, 2006

Filed:

Feb 5, 2002

Appl. No.:

10/467439

Inventors:

Harold G. Selnick - Ambler PA, US
Mary Beth Young - Lansdale PA, US
Philippe G. Nantermet - Lansdale PA, US
James C. Barrow - Harleysville PA, US
Peter D. Williams - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Donnette D. Staas - Harleysville PA, US
Kenneth J. Stauffer - Souderton PA, US
Philip E. Sanderson - Philadelphia PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/4439
C07D 401/12

US Classification:

514340, 514361, 5462687, 5462691, 548127, 548131, 548134

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)—N(R)CH(R)— wherein the nitrogen atom is attached to R, and Rand Rare independently selected from the group consisting of hydrogen, Ccycloalkyl, and Calkyl, or 2) wherein the nitrogen atom is attached to R, and m is 0, 1, or 2.

US Patent:

57144850, Feb 3, 1998

Filed:

Jan 16, 1997

Appl. No.:

8/776075

Inventors:

William C. Lumma - Pennsburg PA
Roger M. Freidinger - Lansdale PA
Stephen F. Brady - Philadelphia PA
Philip E. Sanderson - Philadelphia PA
Dong-Mei Feng - Blue Bell PA
Terry A. Lyle - Lederach PA
Kenneth J. Stauffer - Pottstown PA
Thomas J. Tucker - North Wales PA
Joseph P. Vacca - Telford PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31445
A61K 3150
C07D21108
C07D23704

US Classification:

514247

Abstract:

Compounds of the invention have the following structure: ##STR1##.

US Patent:

6090805, Jul 18, 2000

Filed:

Jun 10, 1998

Appl. No.:

9/095232

Inventors:

Peter D. Williams - Harleysville PA
Michelle A. Sparks - Gwynedd Valley PA
Ian Bell - Harleysville PA
Debra S. Perlow - East Greenville PA
Kenneth Stauffer - Pottstown PA
Roger M. Freidinger - Lansdale PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31535
A61K 3147
C07D26512
C07D21516

US Classification:

5142305

Abstract:

This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

US Patent:

55103693, Apr 23, 1996

Filed:

Jul 22, 1994

Appl. No.:

8/279460

Inventors:

William C. Lumma - Pennsburg PA
Roger M. Freidinger - Lansdale PA
Stephen F. Brady - Philadelphia PA
Philip E. Sanderson - Philadelphia PA
Dong-Mei Feng - Harleysville PA
Terry A. Lyle - Lederach PA
Kenneth J. Stauffer - Pottstown PA
Thomas J. Tucker - North Wales PA
Joseph P. Vacca - Telford PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3140
C07D20706

US Classification:

514422

Abstract:

Compounds of the invention have the following structure: ##STR1## for example ##STR2## These compounds inhibit thrombin and associated thrombosis.