Kevin J Baker

US Patent:

20080097618, Apr 24, 2008

Filed:

Apr 2, 2007

Appl. No.:

11/731944

Inventors:

Kevin Charles Baker - Royal Oak MI, US
Jaroslaw Wieslaw Drelich - Houghton MI, US

International Classification:

A61F 2/28

US Classification:

623 2351, 427 226, 435402

Abstract:

The invention is a medical implantable device which is coated by the method according to the invention. The surface of the substrate used for the implantable device, in the raw condition, following a cleaning regime and physiochemical pretreatments, is coated using a biomimetic process in a supersaturated calcium phosphate solution (SCPS) to obtain the desired coating coverage and morphology maintaining a ratio of calcium to phosphorus pH, as well as solution temperature plays a major role in yielding precipitation of the proper phase of CaP so that composition, morphologies, crystal structures, and solubility characteristics are optimal for the deposition process. The biomimetic coating adds the attribute of osteoconductivity to the implant device. To maximize bone growth, the implant must also induce bone growth, or possess the attribute of osteoinductivity. This attribute is acquired by the use of therapeutic agents, i.e. bone morphogenic proteins (BMP), growth factors, stem cells, etc. The preparation of the SCPS solution is slightly altered so that during the immersion of the implant in the SCPS, the therapeutic agents are co-precipitated and bonded with the CaP directly on the underlying surface of the implant device. A final dipping process into a BMP solution provides an initial burst of cellular activity. For delivering stem and/or progenitor cell, after drying the dipped solution of BMP, the cells are cultured on the surface of the implant.

US Patent:

20110288223, Nov 24, 2011

Filed:

Jan 20, 2011

Appl. No.:

13/010522

Inventors:

Rangaramanujam M. Kannan - Novi MI, US
Kevin C. Baker - Royal Oak MI, US
Robert Bellair - Warren MI, US
Mihai Manitiu - MaComb MI, US
Harry Herkowitz - West Bloomfield MI, US

International Classification:

C08K 3/34
B29C 43/26
B82Y 30/00

US Classification:

524445, 264555, 977734

Abstract:

A biodegradable film and a method of forming a biodegradable film are provided. In one aspect, the biodegradable film includes a reinforced biodegradable polymer including a biodegradable polymer and a reinforcing agent substantially dispersed throughout the biodegradable polymer by rapid depressurization of a supercritical fluid wherein the reinforced biodegradable polymer is formed into the film.

US Patent:

20110288651, Nov 24, 2011

Filed:

Jan 20, 2011

Appl. No.:

13/010513

Inventors:

Rangaramanujam M. Kannan - Novi MI, US
Kevin C. Baker - Royal Oak MI, US
Robert Bellair - Warren MI, US
Mihai Manitiu - MaComb MI, US
Harry Herkowitz - West Bloomfield MI, US

International Classification:

A61F 2/28
C08K 3/34
C08K 3/32
C08K 3/26
A61P 43/00
A61K 35/00
A61K 9/14
A61K 9/127
A61K 38/18
C08J 9/08
C08L 67/04

US Classification:

623 2361, 521 97, 521 91, 521 85, 521 92, 424 931, 424489, 424450, 514 76

Abstract:

A biodegradable nanocomposite and a method of forming a biodegradable nanocomposite are provided. In one aspect, the biodegradable nanocomposite includes a biodegradable polymer and a reinforcing agent substantially dispersed throughout the biodegradable polymer by rapid depressurization of a supercritical fluid. The biodegradable nanocomposite further includes a plurality of pores formed in the nanocomposite, the plurality of pores having an average pore size greater than about 100 μm.