Kevin A Guze

US Patent:

20120253470, Oct 4, 2012

Filed:

Mar 30, 2012

Appl. No.:

13/435259

Inventors:

Kevin A. Guze - Lexington MA, US
Vinicius Souza Rodrigues - Madison Heights MI, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Boston MA

International Classification:

A61F 2/28

US Classification:

623 2351

Abstract:

The technology described herein relates to compositions for promoting bone growth or regeneration. The compositions described herein can comprise bioactive agents and scaffold materials.

US Patent:

20120089030, Apr 12, 2012

Filed:

Jan 18, 2010

Appl. No.:

13/144574

Inventors:

Kevin Guze - Boston MA, US
Michael Short - Coquitlam, CA
Haishan Zeng - Vancouver, CA
Stephen Sonis - Wayland MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
BRITISH COLUMBIA CANCER AGENCY BRANCH - Vancouver BC

International Classification:

A61B 6/00

US Classification:

600476

Abstract:

A method and system for characterizing tissue includes a probe connected to a red LASER source and a Raman spectroscope. The probe includes at least excitation fiber and one or more emission fibers that connect the probe with the LASER source and the Raman spectroscope. The excitation fiber is connected to the red LASER source and terminates in the first end of the probe adjacent the tip of the probe. The emission fibers are connected to the Raman spectroscope and terminate in the first end of the probe adjacent the tip of the probe. In one embodiment, the excitation fiber extends through the central portion of the probe and one or more emission fibers are arranged around the excitation fiber. The tip of the probe is intended to come in contact with the tissue to be examined. The tip includes a central opening to allow red LASER radiation to project out of the end of the red excitation fiber on to the tissue and to permit Raman spectra to enter the emission fiber(s) and travel to the Raman spectroscope. The tip is constructed to have a predefined focal length to position the first end of the probe a predefined distance from the surface of the tissue being examined. The tip can be removable and tips having different focal lengths can be used to accommodate different types of tissues and examinations. A detector can convert the Raman spectra into signals and data for analysis by a computer system. The Raman spectra for tissue in a predefined location can be profiled such that the system can distinguish between healthy and diseased tissue.