Kim H Chen

US Patent:

61214639, Sep 19, 2000

Filed:

Jun 23, 1998

Appl. No.:

9/102869

Inventors:

Roger A. Parker - Cincinnati OH
Michael L. Edwards - Morristown NJ
Mark J. Vaal - Baltimore MD
James E. Matt - Indianapolis IN
Kim S. Chen - San Diego CA
Mark T. Yates - Ann Arbor MI
Paul S. Wright - Cincinnati OH
Steven J. Busch - Stewartsville NJ

Assignee:

Hoechst Marion Roussel, Inc. - Bridgewater NJ

International Classification:

C07D32700
C07D33322
C07D30500
C07D30702

US Classification:

549 4

Abstract:

The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH. sub. 2). sub. m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4; R. sub. 1, R. sub. 5 and R. sub. 6 are independently a C. sub. 1 -C. sub. 6 alkyl group; R. sub. 2, R. sub. 3 and R. sub. 4 are independently hydrogen or a C. sub. 1 -C. sub. 6 alkyl group; Z is thio, oxy or a methylene group; A is a C. sub. 1 -C. sub. 4 alkylene group; X is thio or oxy; and G. sub. 1 and G. sub. 2 are independently hydrogen, C. sub. 1 -C. sub. 6 alkyl or --C(O)--(CH. sub. 2). sub. n --CH. sub. 3 and n is an integer 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.

US Patent:

61145726, Sep 5, 2000

Filed:

Nov 19, 1997

Appl. No.:

8/974112

Inventors:

Roger A. Parker - Cincinnati OH
Paul S. Wright - Cincinnati OH
Steven J. Busch - Stewartsville NJ
Kim S. Chen - San Diego CA
Mark T. Yates - Ann Arbor MI

Assignee:

Hoechst Marion Roussel, Inc. - Bridgewater NJ

International Classification:

C07C 6702
C07C 5900
C07C 4100
A01N 3100

US Classification:

560254

Abstract:

The present invention provides compounds of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Y is thio, oxy or a methylene group; Z is hydrogen or --C(O)--(CH. sub. 2). sub. m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4; R. sub. 1 is C. sub. 1 -C. sub. 6 alkyl; and R. sub. 2, R. sub. 3 and R. sub. 4 are each independently hydrogen or C. sub. 1 -C. sub. 6 alkyl; or a stereoisomer thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.

US Patent:

61334677, Oct 17, 2000

Filed:

Jun 23, 1998

Appl. No.:

9/103215

Inventors:

Michael L. Edwards - Morristown NJ
Mark J. Vaal - Baltimore MD
Roger A. Parker - Cincinnati OH
James E. Matt - Indianapolis IN
Kim S. Chen - San Diego CA
Mark T. Yates - Ann Arbor MI

Assignee:

Hoechst Marion Roussel, Inc. - Somerville NJ

International Classification:

C07F 704

US Classification:

556445

Abstract:

This invention relates to the compounds of 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)methyloxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxyphenylsilyl)methyloxy]phenol, polymorphs thereof and their pharmaceutically acceptable salts, useful as antiatherosclerotic agents.