Kim M Keeling

US Patent:

20050153906, Jul 14, 2005

Filed:

Feb 20, 2002

Appl. No.:

10/079326

Inventors:

David Bedwell - Birmingham AL, US
Kim Keeling - Birmingham AL, US

International Classification:

A61K031/704

US Classification:

514035000, 514039000

Abstract:

The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of administering to said individuals a therapeutically effective dose of an aminoglycoside. In addition, this method may further comprise treating the individual with enzyme replacement therapy. Furthermore, the present invention provides method of pharmacologically suppressing premature stop mutations in an individual with these lysosomal storage diseases, comprising the step of administering to said individual a pharmacologically effective dose of an aminoglycoside.

US Patent:

20060045874, Mar 2, 2006

Filed:

Oct 6, 2005

Appl. No.:

11/244553

Inventors:

David Bedwell - Birmingham AL, US
Kim Keeling - Birmingham AL, US

International Classification:

A61K 31/704
A61K 38/47

US Classification:

424094610, 514035000

Abstract:

The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of administering to said individuals a therapeutically effective dose of an aminoglycoside. In addition, this method may further comprise treating the individual with enzyme replacement therapy. Furthermore, the present invention provides method of pharmacologically suppressing premature stop mutations in an individual with these lysosomal storage diseases, comprising the step of administering to said individual a pharmacologically effective dose of an aminoglycoside.

US Patent:

20190125775, May 2, 2019

Filed:

Apr 17, 2017

Appl. No.:

16/093516

Inventors:

- Birmingham AL, US
David M. BEDWELL - Hoover AL, US
Venkateshwar MUTYAM - Birmingham AL, US
Ming DU - Birmingham AL, US
Kim M. KEELING - Birmingham AL, US

International Classification:

A61K 31/704
A61K 45/06
A61P 11/00
A61K 31/443
A61K 31/47
A61K 31/4745
A61K 31/498

Abstract:

The present disclosure provides compositions and methods for treating and/preventing diseases and conditions associated with premature termination mutations. The methods disclosed herein comprise the step of administering to the subject a therapeutically effective dose of a compound described herein that induces read-through of the premature termination codon. The methods of the present disclosure may further comprise treating the subject with enzyme replacement therapy wherein the enzyme replacement therapy is selected for the disease or condition to be treated. Furthermore, the present disclosure provides method of pharmacologically suppressing premature termination codons in a subject in need of such suppression.