Kimberly A Stanley

US Patent:

53365186, Aug 9, 1994

Filed:

Dec 11, 1992

Appl. No.:

7/989105

Inventors:

Pallassana V. Narayanan - Davie FL
Stephen M. Rowland - Miami FL
Kimberly D. Stanley - Miami FL

Assignee:

Cordis Corporation - Miami Lakes FL

International Classification:

A61F 200
A61M 2300

US Classification:

623 1

Abstract:

A treatment for metallic surfaces and devices having metallic surfaces is described. A film of heptafluorobutylmethacrylate (HFBMA) is applied to a surface by radiofrequency (RF) plasma deposition and subsequently treated with a biologically active agent. A water vapor RF plasma treatment of the HFBMA coating provides reactive groups thereon which can covalently bond to the biologically active agent. Alternatively, a spacer group can be bonded to the activated HFBMA and the biologically active agent can then be bonded to the spacer group. Devices coated according to the invention possess enhanced biocompatibility and the HFBMA coatings are durable even under severe crimping and expansion conditions.

US Patent:

55911404, Jan 7, 1997

Filed:

Apr 6, 1995

Appl. No.:

8/417799

Inventors:

Pallassana V. Narayanan - Davie FL
Kimberly D. Stanley - Florida City FL

Assignee:

Cordis Corporation - Miami Lakes FL

International Classification:

A61M 2500

US Classification:

604269

Abstract:

Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood during implantation or medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the polymeric substrate which had been subjected to radiofrequency plasma treatment with a water vapor medium.

US Patent:

54096960, Apr 25, 1995

Filed:

Nov 22, 1993

Appl. No.:

8/156384

Inventors:

Pallassana V. Narayanan - Davie FL
Kimberly D. Stanley - Florida City FL

Assignee:

Cordis Corporation - Miami Lakes FL

International Classification:

A61L 3300
A61L 2900
A61K 31725
A61K 3562

US Classification:

424 7817

Abstract:

Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood during implant ation or medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the polymeric substrate which had been subjected to radiofrequency plasma treatment with a water vapor medium.

US Patent:

51321084, Jul 21, 1992

Filed:

Nov 8, 1990

Appl. No.:

7/610548

Inventors:

Pallassana V. Narayanan - Davie FL
Kimberly D. Stanley - Florida City FL

Assignee:

Cordis Corporation - Miami Lakes FL

International Classification:

A61L 3300
A61K 3562
A61K 31725
B05D 306

US Classification:

424 7817

Abstract:

Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood during implantation or medical procedures. The biocompatibility enhancing agent is secured to the polymeric substrate by a spacer molecule which is covalently bound to the polymeric substrate which had been subjected to radiofrequency plasma treatment with a water vapor medium.

US Patent:

53564332, Oct 18, 1994

Filed:

Nov 3, 1993

Appl. No.:

8/147017

Inventors:

Stephen M. Rowland - Miami FL
Kimberly D. Stanley - Florida City FL

Assignee:

Cordis Corporation - Miami Lakes FL

International Classification:

A61F 202
A61F 206
A61F 224
A61F 276

US Classification:

623 11

Abstract:

Metallic surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The surfaces are prepared by a two-step procedure including covalently linking an organosilane having amine reactive sites with the surface of the metallic member, typically through a metal oxide thereof. Thereafter, a biologically active agent is covalently linked to the organosilane coating. The two-step process is particularly advantageous for preparing medical devices in the form of stents which need to be bent and flexed during implantation procedures.