Wake Forest School Of Medicine Medical Ctr Blvd, Winston Salem, NC 27157 (336)7164316 (phone), (336)7161278 (fax)
Education:
Medical School Univ of Toronto, Fac of Med, Toronto, Ont, Canada Graduated: 1981
Languages:
English
Description:
Dr. Li graduated from the Univ of Toronto, Fac of Med, Toronto, Ont, Canada in 1981. He works in Winston-Salem, NC and specializes in Radiology. Dr. Li is affiliated with Novant Health Medical Park Hospital and Wake Forest Baptist Medical Center.
King Chuen Li - Stanford CA Mark David Bednarski - Los Altos CA Richard Wood Storrs - San Diego CA Henry Y. Li - Visalia CA Francois Daniel Tropper - Toronto, CA Curtis Kang Hoon Song - Sunnyvale CA Dorothy Anna Sipkins - Palo Alto CA Jeremy Kenji Kuniyoshi - Cupertino CA
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
Use Of Targeted Cross-Linked Nanoparticles For In Vivo Gene Delivery
The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e. g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.
Targeted Cross-Linked Nanoparticles And Their Use In Vivo Gene Delivery
The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e. g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.
King Chuen Li - Stanford CA Mark David Bednarski - Los Altos CA Richard Wood Storrs - San Diego CA Henry Y. Li - Visalia CA Francois Daniel Tropper - Toronto, CA Curtis Kang Hoon Song - Sunnyvale CA Dorothy Anna Sipkins - Palo Alto CA Jeremy Kenji Kuniyoshi - Cupertino CA
Assignee:
Targesome, Inc. - Palo Alto CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
King C. Li - Stanford CA Mark D. Bednarski - Los Altos CA Richard W. Storrs - Union City CA Henry Y. Li - Visalia CA Francois D. Trooper - Oakland CA Curtis K. H. Song - Sunnyvale CA Dorothy A. Sipkins - Palo Alto CA Jeremy K. Kuniyoshi - Cupertino CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
Polymerized liposome particles based upon lipids having a polymerizable functional group and a metal chelator to attach an imaging enhancement agent and lipids having an active targeting group to provide targeted polymerized liposome contrast agents. The polymerized imaging enhancement liposome particles interact with receptor targets holding the image enhancement agent to specific sites providing in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology.
Targeted Polymerized Liposome Diagnostic And Treatment Agents
King Chuen Li - Stanford CA Mark David Bednarski - Los Altos CA Richard Wood Storrs - San Diego CA Henry Y. Li - Visalia CA Francois Daniel Tropper - Toronto, CA Curtis Kang Hoon Song - Sunnyvale CA Dorothy Anna Sipkins - Palo Alto CA Jeremy Kenji Kuniyoshi - Cupertino CA
Assignee:
Targesome, Inc. - Palo Alto CA
International Classification:
A61K 9127
US Classification:
424450
Abstract:
Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with biological targets holding the image enhancement agent to specific sites providing in vitro and in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology. Targeting polymerized liposomes may be linked to or encapsulate a treatment agent, such as, proteins, drugs or hormones for directed delivery to specific biological sites for treatment.
Enhancement Of Bioavailability By Use Of Focused Energy Delivery To A Target Tissue
King Li - Stanford CA Mark Bednarski - Los Altos CA
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61N 700 A61B 5055 A61K 9127 A61K 4800
US Classification:
604507
Abstract:
Targeted tissue in vivo is altered using focused energy to specifically control endothelial permeability and interstitial integrity. Image guidance may be used in combination with physical energy deposition to facilitate the targeted delivery of materials. The method of the invention serves as a platform for delivering pharmaceutical agents, nucleic acids, proteins, liposomes, etc. to cells.
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