Krishan H Kumar

US Patent:

6991801, Jan 31, 2006

Filed:

Apr 5, 2004

Appl. No.:

10/818313

Inventors:

Mark D. Soll - Alpharetta GA, US
Krishan Kumar - Manalapan NJ, US
Robert P. Waranis - Armandale NJ, US
Natalya Shub - Bridgewater NJ, US

Assignee:

Merial Limited - Duluth GA

International Classification:

A01N 25/32

US Classification:

424406, 424405, 514 30, 514248, 514249, 51425205

Abstract:

This invention provides for inter alia, topical anthelmintic formulations which comprise a pharmaceutically active combination consisting of at least one macrocyclic compound and at least one compound selected from the group consisting of praziquantel, morantel and pyrantel, which are dissolved in a non-aqueous solvent or solvent mixture and optionally a thickening agent.

US Patent:

7385041, Jun 10, 2008

Filed:

Feb 26, 2004

Appl. No.:

10/787526

Inventors:

C. Allen Chang - Cupertino CA, US
Krishan Kumar - East Windsor NJ, US
Michael F. Tweedle - Princeton NJ, US

Assignee:

Bracco International B.V. - Amsterdam

International Classification:

C07F 13/00

US Classification:

534 14, 534 10, 424 111, 424 165, 424 169, 424 91, 424 93, 424 94, 424 95

Abstract:

A novel dual functioning excipient for metal chelate contrast agents is disclosed. The present excipient,X[X′(L′)],which is the calcium or zinc salt of the calcium or zinc complex of an organic ligand, enhances safety in that it is able to scavenge both free metal ions and free organic ligand.

US Patent:

8362086, Jan 29, 2013

Filed:

Aug 19, 2005

Appl. No.:

11/207980

Inventors:

Mark D. Soll - Alpharetta GA, US
Peter Hanson - Suwanee GA, US
Krishan Kumar - Manalapan NJ, US

Assignee:

Merial Limited - Duluth GA

International Classification:

A61K 31/63
A61K 31/7048

US Classification:

514603, 514 28, 514460

Abstract:

The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

US Patent:

20050234119, Oct 20, 2005

Filed:

Apr 16, 2004

Appl. No.:

10/826105

Inventors:

Mark Soll - Alpharetta GA, US
Albert Boeckh - Cumming GA, US
Krishan Kumar - Manalapan NJ, US
Natalya Shub - Bridgewater NJ, US

International Classification:

A61K031/415
A01N043/56
A61K031/416

US Classification:

514406000

Abstract:

This invention provides for antiparasitical agents and methods for treating, preventing and controlling external parasites in animals.

US Patent:

20080003282, Jan 3, 2008

Filed:

Oct 13, 2006

Appl. No.:

11/580731

Inventors:

Mark Soll - Alpharetta GA, US
Albert Boeckh - Cumming GA, US
Krishan Kumar - Manalapan NJ, US
Natalya Shub - Bridgewater NJ, US

International Classification:

A01N 25/34
A01N 43/56
A01P 15/00
C07D 231/02

US Classification:

424464000, 514407000, 548367400

Abstract:

This invention provides for antiparasitical agents and methods for treating, preventing and controlling external parasites in animals.

US Patent:

49239856, May 8, 1990

Filed:

May 25, 1988

Appl. No.:

7/198537

Inventors:

Otto A. Gansow - Washington DC
Krishan Kumar - Rockville MD

Assignee:

The United States of America as represented by the Department of Health
& Human Services - Washington DC

International Classification:

C07D25700
C07D25900

US Classification:

540474

Abstract:

A process for synthesizing a 12 membered ring tetraaza macromolecule comprising. The process involves condensing an amide of ethylene diamine having a general formula A: ##STR1## wherein n is an integer from 1 to 5 and w is a member selected from the group consisting of --NO. sub. 2, --NH. sub. 2, --NCS, --COOH, --OCH. sub. 2 OOCH. sub. 3, --NCOCH. sub. 2 --Z with Z being a member selected from the group consisting of Br and I with a nitrogen blocked active ester of a general formula B: ##STR2## wherein PG is an amino protecting group and E is a leaving group.

US Patent:

20190276490, Sep 12, 2019

Filed:

Nov 1, 2017

Appl. No.:

16/346714

Inventors:

- Columbus OH, US
Krishan KUMAR - Powell OH, US

International Classification:

C07K 1/13
C07K 1/107
G01N 33/532
A61K 51/08
A61K 51/10
C07B 59/00

Abstract:

Provided herein are methods for iodinating biomolecules, including proteins and peptides. The methods can be used to successfully and efficiently iodinate biomolecules under relatively mild reaction conditions. As a consequence, the methods described herein can be used to iodinate biomolecules that include, for example, an oxidatively unstable moiety (e.g., an optical dye) without adversely impacting the oxidatively unstable moiety.