Kristen R Johnson

US Patent:

20170226172, Aug 10, 2017

Filed:

Mar 30, 2015

Appl. No.:

15/300048

Inventors:

- New York NY, US
Jeanne Sue MAGRAM - Croton-on-Hudson NY, US
Kristen Leigh JOHNSON - New York NY, US

International Classification:

C07K 14/50

Abstract:

Disclosed herein are FGF23 c-tail fusion proteins, pharmaceutical compositions comprising the FGF23 c-tail fusion proteins, and methods of treatment using the FGF23 c-tail fusion proteins. This application discloses fusion proteins comprising a FGF-23 c-tail protein fused to a heterologous amino acid sequence, wherein said fusion protein modulates serum phosphate levels but does not substantially modulate serum 1, 25 VitD levels. In some embodiments, the FGF-23 c-tail protein is fused to the heterologous amino acid sequence via a linker. This invention also encompasses vectors comprising the nucleic acids disclosed herein, and a host cell comprising the vector or polynucleotides encoding the proteins of the invention.