Kristen L Smith

US Patent:

6344403, Feb 5, 2002

Filed:

Jun 16, 2000

Appl. No.:

09/595735

Inventors:

Sucharita Madhukar - Austin TX
Ramachandran Muralidhar - Austin TX
David L. OMeara - Austin TX
Kristen C. Smith - Austin TX

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

H01L 2120

US Classification:

438503, 117935, 438507, 438509

Abstract:

A semiconductor memory device with a floating gate that includes a plurality of nanoclusters ( ) and techniques useful in the manufacturing of such a device are presented. The device is formed by first providing a semiconductor substrate ( ) upon which a tunnel dielectric layer ( ) is formed. A plurality of nanoclusters ( ) is then grown on the tunnel dielectric layer ( ). The growth of the nanoclusters ( ) may be accomplished using low pressure chemical vapor deposition (LPCVD) or ultra high vacuum chemical vapor deposition (UHCVD) processes. Such growth may be facilitated by formation of a nitrogen-containing layer ( ) overlying the tunnel dielectric layer ( ). After growth of the nanoclusters ( ), a control dielectric layer ( ) is formed over the nanoclusters ( ). In order to prevent oxidation of the formed nanoclusters ( ), the nanoclusters ( ) may be encapsulated using various techniques prior to formation of the control dielectric layer ( ). A gate electrode ( ) is then formed over the control dielectric ( ), and portions of the control dielectric, the plurality of nanoclusters, and the gate dielectric that do not underlie the gate electrode are selectively removed.

US Patent:

20110301105, Dec 8, 2011

Filed:

Mar 30, 2011

Appl. No.:

13/075647

Inventors:

Freda Miller - Toronto, CA
David Kaplan - Toronto, CA
Kristen Smith - San Clemente CA, US
Maryline Paris - Toronto, CA
Sibel Naska - Toronto, CA

Assignee:

The Hospital for Sick Children - Toronto

International Classification:

A61K 31/7028
C12N 5/09
C12Q 1/02
A61K 31/522
A61K 31/5575
A61K 31/357
A61K 31/498
A61K 31/675
A61K 31/4168
A61K 31/352
A61K 31/382
A61K 31/40
A61K 31/4355
A61K 31/09
A61K 31/57
A61K 31/366
A61K 31/14
A61K 31/5375
A61K 31/7034
A61K 31/155
A61K 31/4745
A61P 17/00
A61P 17/02
C12N 5/071

US Classification:

514 25, 435375, 435 29, 51426338, 514573, 514463, 514249, 514 89, 514392, 514456, 514432, 514428, 514291, 514718, 514179, 514453, 514643, 5142392, 514634, 514280

Abstract:

We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.

US Patent:

20170252316, Sep 7, 2017

Filed:

Sep 25, 2015

Appl. No.:

15/513877

Inventors:

- Toronto, CA
David R. KAPLAN - Toronto, CA
Sibel NASKA - Toronto, CA
Kristen Michelle SMITH - San Clemente CA, US
Maryline PARIS - St Cloud, FR

International Classification:

A61K 31/24
A61K 45/06
A61K 9/06
A61K 9/00
A61K 8/44
A61Q 7/00

Abstract:

The invention relates to compositions and methods useful for enhancing hair growth and promoting skin regeneration. Particularly, the invention provides topical compositions including trimebutine, salts, or active metabolites thereof, for enhancing or inducing hair growth and promoting skin regeneration. Compositions comprising trimebutine or a pharmaceutically acceptable salt or active metabolite thereof and their use in the method of promoting hair growth or skin regeneration. Preferably trimebutine is trimebutine maleate or N-desmethyl trimebutine. Compositions are preferably in a form for topical administration, such as a gel.

US Patent:

20160046723, Feb 18, 2016

Filed:

Jun 17, 2015

Appl. No.:

14/741696

Inventors:

- San Diego CA, US
Kristen M. Smith - San Clemente CA, US
Peter Chu - San Diego CA, US
Lioudmila A. Campbell - San Diego CA, US
Eric Ailor - San Diego CA, US

International Classification:

C07K 16/30

Abstract:

Disclosed herein are anti-LGR4 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR4 without disrupting LGR4-RSPO1 binding or signaling, and may disrupt LGR4 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for antibodies that bind LGR4, for example without disrupting LGR4-RSPO binding or signaling.

US Patent:

20140234271, Aug 21, 2014

Filed:

May 5, 2014

Appl. No.:

14/270021

Inventors:

- Toronto, CA
David KAPLAN - Toronto, CA
Kristen SMITH - San Clemente CA, US
Maryline PARIS - Toronto, CA
Sibel NASKA - Toronto, CA

Assignee:

THE HOSPITAL FOR SICK CHILDREN - Toronto

International Classification:

A61K 31/5575
A61K 38/18
A61K 31/353
A61K 31/5375
A61Q 7/00
A61Q 19/00
A61Q 19/08
A61K 8/98
A61K 8/365
A61K 8/49
A61K 8/64
A61K 31/14
A61K 8/41
G01N 33/50
A61K 35/36

US Classification:

424 937, 514573, 514456, 5142392, 435375, 435 29, 506 10, 435 612, 435 613, 435 721

Abstract:

We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.

Address:

1009 Markham Ln APT B, Austin, TX 78753

VIN:

3N1AB61E47L691349

Make:

NISSAN

Model:

SENTRA

Year:

2007

Address:

1818 Augusta Dr APT 15, Houston, TX 77057

VIN:

4T1BE46K37U091919

Make:

TOYOTA

Model:

CAMRY

Year:

2007