Claude Benedict - Cambridge MA, US John Diener - Cambridge MA, US David Epstein - Belmont MA, US Dilara Grate - Cambridge MA, US Sara Chesworth Keene - Tewksbury MA, US Jeffrey Kurz - Arlington MA, US Markus Kurz - Newton MA, US Thomas Greene McCauley - Cambridge MA, US James Rottman - Sudbury MA, US Kristin Thompson - Arlington MA, US Charles Wilson - Concord MA, US Anna J. Zoltoski - South Boston MA, US
Assignee:
Archemix Corp. - Cambridge MA
International Classification:
C07H 21/04
US Classification:
536 245
Abstract:
The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
Materials And Methods For The Generation Of Transcripts Comprising Modified Nucleotides
John L. Diener - Cambridge MA, US Anthony Dominic Keefe - Cambridge MA, US Kristin Thompson - Arlington MA, US Chunhua Wang - Acton MA, US Shuhao Zhu - Lincoln MA, US
Assignee:
Archemix Corp. - Cambridge MA
International Classification:
C12N 9/12
US Classification:
435194, 435183, 435 691
Abstract:
Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
Andrew Ellington - Austin TX, US Jay Hesselberth - Seattle WA, US Kristin Thompson - Arlington MA, US Michael Robertson - Santa Cruz CA, US Letha Sooter - Austin TX, US Eric Davidson - Houston TX, US J. Cox - Austin TX, US Timothy Riedel - New Braunfels TX, US Charles Wilson - Concord MA, US Sharon Cload - Cambridge MA, US Anthony Keefe - Cambridge MA, US
International Classification:
C07H021/02 C12N015/85
US Classification:
435/455000, 536/023100
Abstract:
Compositions and methods are provided to make, isolate, characterize and use regulatable, catalytically active nucleic acids (RCANA). The present invention is directed to RCANA that transduce molecular recognition into catalysis. Also, RCANAs according to the invention can be used as regulatory elements to control the expression of one or more genes in a metabolic pathway. RCANAs can also be used as regulated selectable markers to create a selective pressure favoring (or disfavoring) production of a targeted bioproduct.
Gene Knock-Down By Intracellular Expression Of Aptamers
David Epstein - Belmont MA, US Harold Marsh - Charlestown MA, US Shannon Pendergrast - Cambridge MA, US Kristin Thompson - Arlington MA, US
International Classification:
C12Q001/68 C07H021/02 A61K048/00
US Classification:
435006000, 514044000, 536023100
Abstract:
Materials and methods are provided for target validation by gene knock-down with intracellularly expressed aptamers and siRNAs. The aptamers produced by the materials and methods of the invention are useful in target validation for therapeutics development.
Controlled Modulation Of The Pharmacokinetics And Biodistribution Of Aptamer Therapeutics
Judith Healy - Lexington MA, US Markus Kurz - Newton MA, US Thomas McCauley - Cambridge MA, US Kristin Thompson - Arlington MA, US Charles Wilson - Concord MA, US Dorothy Margolskee - Upper Montclair NJ, US
International Classification:
A61K 48/00 A61K 9/14
US Classification:
514044000, 424486000
Abstract:
Materials and methods are provided to modulate, in a controlled manner, the pharmacokinetic and biodistribution properties of nucleic acid aptamers, and to enhance their safety and efficacy properties as therapeutic agents.
Aptamer Therapeutics Useful In The Treatment Of Complement-Related Disorders
Claude Benedict - Cambridge MA, US John Diener - Cambridge MA, US David Epstein - Belmont MA, US Dilara Grate - Cambridge MA, US Sara Keene - Tewksbury MA, US Jeffrey Kurz - Arlington MA, US Markus Kurz - Newton MA, US Thomas McCauley - Cambridge MA, US James Rottman - Sudbury MA, US Kristin Thompson - Arlington MA, US Charles Wilson - Concord MA, US Anna Zoltoski - South Boston MA, US
International Classification:
A61K 48/00 C12Q 1/68 C07H 21/02
US Classification:
514044000, 536023100, 435006000
Abstract:
The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
Aptamers To The Human Il-12 Cytokine Family And Their Use As Autoimmune Disease Therapeutics
John Diener - Cambridge MA, US David Epstein - Belmont MA, US Alicia Ferguson - Somerville MA, US Nobuko Hamaguchi - Framingham MA, US Shannon Pendergrast - Cambridge MA, US Pooja Sawhney - Arlington MA, US Kristin Thompson - Arlington MA, US
The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
Dr. Thompson graduated from the Ohio State University College of Medicine in 1996. She works in Dublin, OH and specializes in Internal Medicine and Adolescent Medicine. Dr. Thompson is affiliated with Ohio State University Wexner Medical Center.
Citizens Mortgage Corporation Riverside, RI Jan 2007 to Apr 2010 Processor IIICountrywide Home Loans East Greenwich, RI Jun 2005 to Nov 2006 UnderwriterMortgage Pros USA East Greenwich, RI May 2004 to May 2005 Sales ManagerUnion Federal Savings Bank North Providence, RI Jun 2003 to May 2004 Loan OriginatorTrish McEvoy Boston, MA Oct 2002 to Jun 2003 Regional Make-up ArtistKiehls/Nordstrom Providence, RI Oct 1999 to Oct 2002 Business Manager
Education:
University of Rhode Island Kingston, RI 1997 Bachelor of Science in Resource Development/Dietetics
University of Illinois at Urbana-Champaign - Mathematics
Tagline:
....come back to me
Kristin Thompson
Education:
University of Texas at Austin - Civil Engineering
Kristin Thompson
Education:
University of Montana - Missoula - Speech and Language Pathology
Kristin Thompson
Work:
My house - Full time mommy and wife
Kristin Thompson
About:
My name is Kristin, and I am a college junior in my 20s. I go to Villanova University, and am a sister of Alpha Gamma Delta. Crumbs and Curls is about beauty, fashion, baking, and crafting through the...