Kristin D Wilson

US Patent:

20170364664, Dec 21, 2017

Filed:

Sep 5, 2017

Appl. No.:

15/696159

Inventors:

- Westminster CO, US
Carsten Schnatwinkel - Boulder CO, US
Kristin Wilson - Denver CO, US
Nathan T. Martin - Boulder CO, US
Joseph Krueger - Andover MA, US
Holger Lange - Enger, DE

Assignee:

Flagship Biosciences, Inc. - Westminster CO

International Classification:

G06F 19/00
G06K 9/62
G06T 7/00

Abstract:

The disclosure concerns a method for patient stratification and selection of patients who are candidates for a specific therapy is described which is based on quantifying one or more digital image analysis feature distributions from stained tissue. The method extends beyond the abilities of a manual observer and a microscope, and generally comprises: acquiring digital images of stained tissue sections from patients submitted for evaluation, applying an algorithm process to said images with a computer to extract the morphometric and staining features of image pixels and tissue objects, deriving one or more distribution function for one or more image analysis features, calculating a summary statistic of the one or more distribution functions, and using said summary statistic along with an associated predefined patient stratification paradigm to separate a patient cohort into distinct strata which correspond to a decision to include or exclude a patient for a specific therapy.