The invention relates to 8-aminoalkylpsoralens, having essentially no erythematic photosensitizing activity but at the same time having substantial DNA-binding photosensitizing activity, making them of especial interest from the standpoint of suntanning and psoriasis treatment, characteristics which are unpredictable when the compounds are compared with psoralens of similar but different structure.
The invention relates to 8-aminoalkyl-4-alkylisopsoralens, especially 8-aminomethyl-4-methylisopsoralen, having enhanced photosensitizing activity, especially oral and topical activity, pharmaceutical compositions thereof, and method of effecting photosensitization therewith.
The invention relates to 5'-aminoalkyl-4'-alkylpsoralens, having essentially no erythematic photosensitizing activity but at the same time having substantial DNA-binding photosensitizing activity, making them of especial interest from the standpoint of suntanning and psoriasis treatment, characteristics which are unpredictable when the compounds are compared with psoralens of similar but different structure.
The invention relates to 4,5',8-trialkylpsoralens, having a substituent on the 4' carbon atom which is selected from hydroxyalkoxyalkyl and hydroxyalkylaminoalkyl, which are characterized by enhanced photosensitizing activity, especially oral activity, including comparable maxima, early onset, and especially rapid decline, as well as low toxicity, when contrasted with psoralens of different structure.
The invention relates to 5'-aminoalkyl-4',4,8-trialkylpsoralens having enhanced photosensitizing activity, especially oral and topical activity, as well as low toxicity, when compared with psoralens of different structure.
alpha. -Loweralkylfurocoumarins are produced by forming a. beta. -haloalk-2-enyl, e. g. ,. beta. -haloallyl, ether of a hydroxycoumarin having an active hydrogen in the position ortho to the hydroxy group, and heating the formed ether, preferably in dimethylaniline or like basic amine solvent. An abnormal Claisen rearrangement produces a novel o-hydroxy-(. beta. -haloalk-2-enyl) coumarin intermediate which can be dehydrohalogenated directly without isolation to the desired. alpha. -loweralkylfurocoumarin, e. g. ,. alpha. -methylfurocoumarin.
Process For Making .Alpha.-Loweralkylfurocoumarins
alpha. -Loweralkylfurocoumarins are produced by forming a. beta. -haloalk-2-enyl, e. g. ,. beta. -haloallyl, ether of a hydroxycoumarin having an active hydrogen in the position ortho to the hydroxy group, and heating the formed ether, preferably in dimethylaniline or like basic amine solvent. An abnormal Claisen rearrangement produces a novel o-hydroxy-(. beta. -haloalk-2-enyl) coumarin intermediate which can be dehydrohalogenated directly without isolation to the desired. alpha. -loweralkylfurocoumarin, e. g. ,. alpha. -methylfurocoumarin.
The invention relates to 5'-aminoalkyl-4',4-dialkylpsoralens having enhanced photosensitizing activity, especially oral activity, including early onset, increased maximum, and rapid decline, as well as low toxicity, when compared with psoralens of different structure.
Kurt Kaufman (1980-1984), Blake Tilley (2002-2006), Veronica Hoke (1970-1970), Leslye McKinney (1992-1996), Steve Hines (1969-1973), Pat Smith (1966-1970)
"I can definitely feel like the forward momentum is there" jobs at the union hall are picking up, says Kurt Kaufman, 31. A union electrician, he worked steadily until 2006. He has since spent as much as nine months between jobs.
Date: Jan 01, 2012
Category: Entertainment
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Youtube
Jerusalem with Kurt Kaufman
CAMINHO DE JERUSALEM.
Duration:
2m 28s
Dino Bravo vs Kurt Kaufman
11/22/86 Superstars.
Duration:
2m 23s
Episode 2: Grow Your Cannabis Business Social...
One of the best things you can do for your cannabis career is to build...
Duration:
36m 24s
Megiddo with Kurt Kaufman
Megiddo with Kurt Kaufman SAR- EL TOURS FILM BY DUDU KOREN.
Duration:
1m 58s
Andy Kaufman - SNL
Taking the stage, Andy Kaufman tell jokes, does impressions, gets flus...