Lakshmi Venkata Cyr

US Patent:

54950449, Feb 27, 1996

Filed:

Oct 29, 1993

Appl. No.:

8/145074

Inventors:

Robert S. Phillips - Athens GA
Lakshmi V. Cyr - Athens GA

Assignee:

University of Georgia Research Foundation, Inc. - Athens GA

International Classification:

C07C22936
A61K 31195

US Classification:

562449

Abstract:

The present invention provides inhibitors of kynureninase having the formula ##STR1## where X is CO or CHOH; R. sub. A and R. sub. B, independently of one another, are H, a halogen, a halovinyl group, or a small alkyl or haloalkyl group having one to three carbon atoms; A is a H or an acetyl group; R. sub. 1 is H, NH. sub. 2, NR. sub. 6 R. sub. 7, NO. sub. 2, halogen, CF. sub. 3 or a small alkyl group having from one to three carbon atoms, wherein: R. sub. 6 and R. sub. 7, independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R. sub. 6 or R. sub. 7 can be a formyl group; R. sub. 2 is OH, H, halogen, CF. sub. 3 or a small alkyl group having from one to three carbon atoms; and R. sub. 3, R. sub. 4 and R. sub. 5, independently of one another, are H, halogen, CF. sub. 3, NO. sub. 2, NH. sub.