Laura Ann Currie

US Patent:

56228678, Apr 22, 1997

Filed:

Oct 19, 1994

Appl. No.:

8/326036

Inventors:

Stephen A. Livesey - Eltham, AU
Jerome Connor - Houston TX
Laura M. Currie - Houston TX

Assignee:

Lifecell Corporation - The Woodlands TX

International Classification:

A61K 3514

US Classification:

436 18

Abstract:

This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.

US Patent:

59196149, Jul 6, 1999

Filed:

May 8, 1997

Appl. No.:

8/852921

Inventors:

Stephen A. Livesey - Conroe TX
Jerome Connor - The Woodlands TX
Laura M. Currie - Houston TX

Assignee:

LifeCell Corporation - The Woodlands TX

International Classification:

A01N 102

US Classification:

435 2

Abstract:

This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets. In particular, compositions comprising amiloride, adenosine and sodium nitroprusside are disclosed.

US Patent:

62216694, Apr 24, 2001

Filed:

Feb 13, 1996

Appl. No.:

8/600343

Inventors:

Stephen A. Livesey - Conroe TX
Jerome Connor - The Woodlands TX
Laura M. Currie - Spring TX

Assignee:

LifeCell Corporation - Branchburg NJ

International Classification:

G01N 3100
A61K 3514

US Classification:

436 18

Abstract:

This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to retain their functional integrity during storage. In addition, the inhibitor system prevents the generation of cytokines in the platelet preparation during storage at both 22. degree. C. and 4. degree. C. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.