Laura B Goodrich

US Patent:

7651474, Jan 26, 2010

Filed:

Jun 3, 2004

Appl. No.:

10/861199

Inventors:

Geert Van Waeg - Brussels, BE
Bruce W. Gibbs - Arvada CO, US
Marc Antoon - Leuven, BE
Laura Goodrich - Lakewood CO, US

Assignee:

CaridianBCT, Inc. - Lakewood CO

International Classification:

A61M 37/00
C02F 1/44

US Classification:

604 616, 604 615, 604 601, 604 609, 210645

Abstract:

A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell collection procedure. The procedure preferably involves filtering the separated red blood cells in a high hematocrit (high-crit) state prior to addition of storage solution thereto. Preferably, a storage solution is passed through the leukoreduction filter after the RBCs have been filtered therethrough. The red blood cell collection filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component, as described.

US Patent:

8296071, Oct 23, 2012

Filed:

Mar 14, 2005

Appl. No.:

11/079894

Inventors:

Richard Alan Edrich - Denver CO, US
Laura Goodrich - Lakewood CO, US
Glen Delbert Antwiler - Lakewood CO, US

Assignee:

Terumo BCT Biotechnologies, LLC - Lakewood CO

International Classification:

G01N 33/48

US Classification:

702 19

Abstract:

Methods, devices and device components are presented for uniformly treating fluids undergoing mixing with electromagnetic radiation. In one aspect, the present invention provides methods of treating a fluid undergoing continuous fluid mixing wherein net radiant energies necessary to provide uniform treatment of the fluid samples with electromagnetic radiation are calculate on the basis of the volume, mass or mixing rate of the fluid or any combination of these variables. In another aspect, the present invention provides algorithms for determining net radiation energies, radiant powers, and/or illumination times necessary for providing uniform treatment of fluid samples. The present invention provides methods for uniformly reducing pathogens in biological fluids, including blood and blood components.

US Patent:

20030077264, Apr 24, 2003

Filed:

Sep 18, 2002

Appl. No.:

10/247262

Inventors:

Laura Goodrich - Lakewood CO, US

International Classification:

A61K045/00
A61K035/78

US Classification:

424/093720, 424/093730, 424/754000

Abstract:

Methods and compositions prolonging the storage life and/or increasing the safety of a blood product, such as whole blood, red blood cells, white blood cells, platelets, serum and aqueous additive solutions for storage of such blood products are provided. Storage solutions of this invention comprise a composition selected from the group consisting of garlic extract, allicin, other microorganism-growth-inhibiting compounds derived from garlic, and analogs and derivatives of allicin and said other compounds, in an amount effective to inhibit growth of at least one selected microorganism which is a bacterium, virus, fungus or parasite. The storage additive solutions of this invention can increase platelet storage life by at least about 20%, preferably at least about 40%.

US Patent:

20030141260, Jul 31, 2003

Filed:

Dec 23, 2002

Appl. No.:

10/328717

Inventors:

Frank Corbin - Littleton CO, US
Dennis Hlavinka - Arvada CO, US
Laura Goodrich - Lakewood CO, US
Raymond Goodrich - Lakewood CO, US

International Classification:

A61L002/08

US Classification:

210/748000, 210/758000, 210/764000, 422/022000, 422/029000

Abstract:

Methods for decontaminating fluids such as blood products, particularly platelets or red blood cells, are provided. The methods include mixing substantially non-toxic amounts of an endogenous photosensitizer such as riboflavin, or an endogenously-based derivative photosensitizer, with the fluid, increasing the dissolved oxygen content of the fluid to an amount sufficient to enhance a reaction of the photosensitizer in which singlet oxygen is formed and reduce competing reactions; and exposing the fluid to visible light photoradiation to activate the photosensitizer and substantially inactivate the pathogens. Blood products produced by the method, and systems for carrying out the method are also provided.

US Patent:

20030215785, Nov 20, 2003

Filed:

Apr 28, 2003

Appl. No.:

10/425282

Inventors:

Laura Goodrich - Lakewood CO, US
Raymond Goodrich - Lakewood CO, US
Deanna Gampp - Thornton CO, US
Robert Lockerbie - Littleton CO, US

Assignee:

Gambro, Inc. - Lakewood CO

International Classification:

A01N001/02

US Classification:

435/002000

Abstract:

This invention relates to the addition of platelet activation inhibitors to solutions used in the pathogen reduction and subsequent storage of platelets. More particularly, the invention relates to the addition of adenylate cyclase stimulators and phosphodiesterase inhibitors to a platelet pathogen reduction and storage solution.

US Patent:

20030219354, Nov 27, 2003

Filed:

Feb 3, 2003

Appl. No.:

10/357599

Inventors:

Dennis Hlavinka - Arvada CO, US
Raymond Goodrich - Lakewood CO, US
Laura Goodrich - Lakewood CO, US
Daniel McGraw - Riverton UT, US

International Classification:

A61L002/00
A01N001/00

US Classification:

422/022000, 422/028000, 422/029000, 422/044000, 422/186000, 250/455110

Abstract:

Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, nontoxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.

US Patent:

20030219712, Nov 27, 2003

Filed:

Jan 31, 2003

Appl. No.:

10/355681

Inventors:

Laura Goodrich - Lakewood CO, US
Raymond Goodrich - Lakewood CO, US

International Classification:

C12N005/00
C12N005/02

US Classification:

435/002000, 435/374000

Abstract:

This invention relates to the addition of glycolytic inhibitors to solutions used to pathogen reduce and subsequent storage of blood components such as platelets. More particularly, the invention relates to the addition of 2-deoxy-D-glucose to a platelet pathogen reduction and storage solution.

US Patent:

20030228564, Dec 11, 2003

Filed:

Feb 10, 2003

Appl. No.:

10/364661

Inventors:

Richard Edrich - Denver CO, US
Laura Goodrich - Lakewood CO, US
Reinhold Deppisch - Hechingen, DE
Dennis Hlavinka - Arvada, CO
Robert Lockerbie - Littleton CO, US
Werner Beck - Rottenburg, DE

International Classification:

A01N001/02
A61K031/7076
A61K031/198
A61K033/00

US Classification:

435/002000, 424/718000, 514/047000, 514/048000, 514/562000, 514/565000

Abstract:

This invention provides methods and compositions for using nitric oxide in a photoradiation pathogen inactivation process for whole blood and blood components to improve pathogen kill and to improve preservation of the quality of the blood components. This invention provides methods for using nitric oxide in combination with oxygen, photosensitizers, quencher and/or glycolysis inhibitor, and compositions comprising blood components decontaminated by these methods. Nitric oxide is provided using nitric oxide gas, or nitric oxide generators such as L-arginine, and/or N-acetyl-cysteine. This invention also provides compositions suitable for photoradiation pathogen inactivation that include fluid comprising a blood component, a photosensitizer, and dissolved nitric oxide. This invention provides decontamination systems useful for performing the methods of this invention and methods for making the decontamination systems. This invention also provides methods for decontaminating fluids and methods for increasing the storage life and quality of photochemically decontaminated platelets.