Lawrence R Dick

US Patent:

6613541, Sep 2, 2003

Filed:

Oct 19, 1999

Appl. No.:

09/419551

Inventors:

Gopalakrishna R. Vaddi - Hockessin DE
Ross L. Stein - Sudbury MA
Lawrence R. Dick - Natick MA
Vito J. Palombella - Needham MA
Eric S. Lightcap - Natick MA
Peter J. Elliott - Marlboro MA
Julian Adams - Brookline MA
Teresa A. McCormack - Medford MA
Stephen J. Brand - Lincoln MA
Dan R. Burns - Skillman NJ

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12Q 137

US Classification:

435 23, 435 24, 435 692

Abstract:

The invention relates to methods for measuring proteasome activity in biological samples. More particularly, then invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.