Lawrence Talbert Mathews

US Patent:

6835544, Dec 28, 2004

Filed:

Dec 19, 2000

Appl. No.:

09/742684

Inventors:

Lawrence W. Mathews - Ann Arbor MI
Kunihiro Tsuchida - San Diego CA

Assignee:

The Salk Institute for Biological Studies - LaJolla CA

International Classification:

G01N 3353

US Classification:

435 71, 435 6, 530351

Abstract:

In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, a hydrophobic, trans-membrane domain, and an intracellular, receptor domain having serine kinase-like activity. The invention receptors optionally further comprise a second hydrophobic domain at the amino terminus thereof. The invention receptor proteins are further characterized by having sufficient binding affinity for at least one member of the activin/TGF- superfamily of polypeptide growth factors such that concentrations of 10 nM of said polypeptide growth factor occupy 50% of the binding sites of said receptor protein. A presently preferred member of the invention superfamily of receptors binds specifically to activins, in preference to inhibins, transforming growth factor-, and other non-activin-like proteins. DNA sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed.

US Patent:

7893213, Feb 22, 2011

Filed:

May 11, 2007

Appl. No.:

11/747869

Inventors:

Lawrence S. Mathews - Ann Arbor MI, US
Kunihiro Tsuchida - San Diego CA, US

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C07K 16/18
A61K 39/395

US Classification:

5303871, 5303881, 4241301

Abstract:

In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein:.

US Patent:

20050186593, Aug 25, 2005

Filed:

Dec 7, 2004

Appl. No.:

11/007077

Inventors:

Lawrence Mathews - Ann Arbor MI, US
Wylie Vale - La Jolla CA, US
Kunihiro Tsuchida - San Diego CA, US

International Classification:

C12Q001/68
C07H021/04
C07K014/705

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, a hydrophobic, trans-membrane domain, and an intracellular, receptor domain having serine kinase-like activity. The invention receptors optionally further comprise a second hydrophobic domain at the amino terminus thereof. The invention receptor proteins are further characterized by having sufficient binding affinity for at least one member of the activin/TGF-β superfamily of polypeptide growth factors such that concentrations of ≦10 nM of said polypeptide growth factor occupy ≦50% of the binding sites of said receptor protein. A presently preferred member of the invention superfamily of receptors binds specifically to activins, in preference to inhibins, transforming growth factor-β, and other non-activin-like proteins. DNA sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed.

US Patent:

61628964, Dec 19, 2000

Filed:

Jun 7, 1995

Appl. No.:

8/476123

Inventors:

Lawrence W. Mathews - Ann Arbor MI
Wylie W. Vale - La Jolla CA
Kunihiro Tsuchida - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C07K 1471
C12N 1512

US Classification:

530350

Abstract:

In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, a hydrophobic, trans-membrane domain, and an intracellular, receptor domain having serine kinase-like activity. The invention receptors optionally further comprise a second hydrophobic domain at the amino terminus thereof. The invention receptor proteins are further characterized by having sufficient binding affinity for at least one member of the activin/TGF-. beta. superfamily of polypeptide growth factors such that concentrations of. ltoreq. 10 nM of said polypeptide growth factor occupy. gtoreq. 50% of the binding sites of said receptor protein.