Lawrence M Pfeffer from 2489 Windy Oaks Dr, Memphis, TN 38139, age 74, Phone: (901)7580624

Us Patents

Interferon Gene Signature And Methods Of Use Thereof
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US Patent:

20130261018, Oct 3, 2013
Filed:

Oct 13, 2011
Appl. No.:

13/880209
Inventors:

Lawrence Pfeffer - Germantown TN, US
Meiyun Fan - Lakeland TN, US
Susan R. Pfeffer - Germantown TN, US
Charles Handorf - Memphis TN, US
Assignee:

University of Tennessee Research Foundation - Knoxville TN
International Classification:

G01N 33/68
US Classification:

506 9, 435 612, 436501, 435 611, 435 792, 506 16, 506 18
Abstract:

The present invention is a method and kit for determining responsiveness of a subject to treatment with a Type I interferon based upon the expression of gene signatures shown to be stimulated by interferon. A method for testing the propensity of a test compound to induce a Type I interferon response is also provided.

Method To Detect Sensitivity To Alpha-Interferon Therapy
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US Patent:

51457733, Sep 8, 1992
Filed:

May 25, 1989
Appl. No.:

7/357075
Inventors:

Anthony P. Albino - New York NY
David M. Nanus - New Rochelle NY
Neil H. Bander - New York NY
Lawrence M. Pfeffer - New York NY
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

G01N 33574
US Classification:

435 723
Abstract:

This invention provides a method of detecting sensitivity to alpha-interferon therapy which comprises contacting a sample with a monoclonal antibody under conditions so as to form an antibody-antigen complex, detecting the complex so formed, and thereby detecting sensitivity to alpha-interferon.

Bromodomain Inhibitors To Target Therapy-Resistant Cancer
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US Patent:

20220296592, Sep 22, 2022
Filed:

Aug 28, 2020
Appl. No.:

17/639114
Inventors:

- Knoxville TN, US
Lawrence M. Pfeffer - Memphis TN, US
Yali He - Memphis TN, US
Debolina Ganguly - Memphis TN, US
International Classification:

A61K 31/4995
C07D 487/08
A61K 31/495
A61K 31/17
A61P 35/00
Abstract:

Novel inhibitors of the bromodomain of Brahma-related gene 1 (BRG1) are described. Also described are methods of treating glioblastoma using inhibitors of the BRG1 bromodomain in combination with chemotherapeutics, such as DNA alkylating agents. As described herein, the inhibitors sensitize glioblastoma cells, including chemoresistant glioblastoma cells, to DNA alkylating agents, for example, temozolomide and carmustine.

Resumes

Muirhead Professor Of Pathology

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Location:

Memphis, TN

Industry:

Biotechnology

Work:

Uthsc Jan 2005 - Oct 2018
Director of the Center For Cancer Research
American Society For Biochemistry and Molecular Biology (Asbmb) Aug 2010 - Oct 2015
Editorial Board Member
University of Tennessee Health Science Center May 2013 - Aug 2015
Interim Vice Chancellor of Research
Rockefeller University Jul 1987 - Jun 1991
Associate Professor
University of Tennessee Health Science Center Jul 1987 - Jun 1991
Muirhead Professor of Pathology

Education:

Cornell University 1972 - 1997
Doctorates, Doctor of Philosophy, Molecular Biology, Biochemistry

Skills:

Cell Biology
Biochemistry
Molecular Biology
Cancer
Science
Research
Immunohistochemistry
Cancer Research
Genetics
Life Sciences
Cell Culture
Pcr
Lifesciences
Western Blotting
Tissue Culture
Cell
Flow Cytometry
Animal Models
Immunology
Genomics
Grant Writing
Molecular Cloning
Protein Chemistry
Bioinformatics
Biotechnology
Neuroscience
Gene Expression
In Vivo
Microscopy
Confocal Microscopy
Dna
Protein Expression
Drug Discovery
Elisa
Qpcr
Fluorescence Microscopy
Immunofluorescence
In Vitro
Molecular Genetics
Program Management
Medical Education

Lawrence Pfeffer

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Lawrence Pfeffer

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Location:

United States

Name / Title

Company / Classification

Phones & Addresses

Lawrence Pfeffer
Pathologist

University Pathology Group PC
Hospital & Health Care · Medical Doctor's Office

930 Madison Ave, Memphis, TN 38103
(901)7257551

Isbn (Books And Publications)

Mechanisms of Interferon Actions

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Author
Lawrence M. Pfeffer

ISBN #
0849361451

Mechanisms of Interferon Actions

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Author
Lawrence M. Pfeffer

ISBN #
0849361478

Classmates

Lawrence Pfeffer Brx NY ...

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Lawrence Pfeffer 1968 graduate of Bronx High School of Science in Bronx, NY is on Classmates.com. See pictures, plan your class reunion and get caught up with Lawrence and other ...