Bradley W. Caprathe - Redford MI Horace A. DeWald - Ann Arbor MI Juan C. Jaen - Plymouth MI Lawrence D. Wise - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 31495 A61K 31535 C07D40512 C07D41314
US Classification:
5142305
Abstract:
Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virture of their dopamine autoreceptor agonist activity. Methods of preparation, pharmeceutical compositions, and methods for treating psychoses, such a schizophrenia, are also described.
Substituted Tetrahydropyridines As Central Nervous System Agents
Juan C. Jaen - Plymouth MI David G. Nickell - Ann Arbor MI Donna M. Reynolds - Plymouth MI Sarah J. Smith - Ann Arbor MI Lawrence D. Wise - Ann Arbor MI David J. Wustrow - Ann Arbor MI
Assignee:
Warner-Lambert Co. - Morris Plains NJ
International Classification:
A61K 3144 C07D21304
US Classification:
514332
Abstract:
Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
Phenyl And Heterocyclic Tetrahydropyridyl Alkoxy-Benzheterocyclic Compounds As Antipsychotic Agents
Bradley W. Caprathe - Redford MI Horace A. DeWald - Ann Arbor MI Juan C. Jaen - Plymouth MI Lawrence D. Wise - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 3144 C07D40112 C07D40512
US Classification:
514231
Abstract:
Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virtue of their dopamine autoreceptor agonist activity. Methods of preparation, pharmaceutical compositions, and methods for treating psychoses, such as schizophrenia, are also described.
Substituted 1,2,3,6-Tetrahydropyridines As Central Nervous System Agents
Bradley W. Caprathe - Redford MI Juan C. Jaen - Plymouth MI Lawrence D. Wise - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 31505 C07D4014
US Classification:
514252
Abstract:
Substituted 1,2,3,6-tetrahydropyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
4-(1,2,5,6-Tetrahydro-1-Alkyl-3-Pyridinyl)-2-Thiazolamines And 4-(Hexahydro-1-Alkyl-3-Pyridinyl)-2-Thiazolamines
Juan C. Jaen - Plymouth MI Lawrence D. Wise - Ann Arbor MI Haile Tecle - Ann Arbor MI Stephen C. Bergmeier - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D41704 A61K 31425
US Classification:
546280
Abstract:
A unique series of 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkylpyridinyl)-2-thiazolamines are disclosed. These compounds are useful as dopaminergic agents. Intermediates for preparing the compounds, pharmaceutical compositions containing them, and methods for using the pharmaceutical compositions for treating human psychosis, elevated blood pressure, Parkinson's disease, hyperprolactinaemia, sexual disorders, and acromegaly are described.
Hetero [F] Fused Carbocyclic Pyridines As Dopaminergic Agents
Bradley W. Caprathe - Redford MI Juan C. Jaen - Plymouth MI Lawrence D. Wise - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 31345 C07D49804 C07D51304
US Classification:
514293
Abstract:
Hetero [f] fused carbocyclic pyridines are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
4 Or 5-(Substituted Piperazinylalkyl)-2-Aminothiazoles As Antipsychotic Agents
Substituted 2-aminothiazoles are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
Substituted Tetrahydropyridines And Their Use As Central Nervous System Agents
Juan C. Jaen - Plymouth MI David G. Nickell - Ann Arbor MI Donna M. Reynolds - Plymouth MI Sarah J. Smith - Ann Arbor MI Lawrence D. Wise - Ann Arbor MI David J. Wustrow - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D40114 C07D40514 C07D41714 A61K 3144
US Classification:
546255
Abstract:
Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.