Lee J Anderson

US Patent:

7537905, May 26, 2009

Filed:

Jan 15, 2003

Appl. No.:

10/346367

Inventors:

Dennis J. Slamon - Woodland Hills CA, US
Lee A. Anderson - Los Angeles CA, US
Charles L. Ginther - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/574

US Classification:

435 723, 435 6

Abstract:

This invention relates to methods to diagnose colon cancer and other proliferative diseases. Gene 26#77 is identified herein as a novel oncogene. Methods are provided for diagnosing and treating a disease or disorder characterized by amplification of the 26#77 gene and/or overexpression of 26#77 gene products. The 26#77 gene is located on chromosome 20q13. 2, a region whose amplification is associated with a poor cancer prognosis. The 26#77 gene is amplified and 26#77 RNA and protein are overexpressed in 60% of colorectal cancers.

US Patent:

20060147930, Jul 6, 2006

Filed:

Jan 15, 2004

Appl. No.:

10/539868

Inventors:

Dennis Slamon - Woodland Hills CA, US
Lee Anderson - Los Angeles CA, US
Charles Ginther - Los Angeles CA, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

This invention relates to methods to diagnose colon cancer and other proliferative diseases by detecting amplification of genes and gene products on chromosome 20q13.2, a region whose amplification is associated with a poor cancer prognosis.