Lee E Hall

US Patent:

6881536, Apr 19, 2005

Filed:

Mar 30, 1995

Appl. No.:

08/413536

Inventors:

Haresh P. Shah - Gaithersburg MD, US
Lee O. Hall - Miami Lakes FL, US
Michael J. Powell - Danville CA, US
Richard J. Massey - Rockville MD, US

Assignee:

BioVeris Corporation - Gaithersburg MD

International Classification:

G01N033/543
G01N033/546
G01N033/548
G01N033/551
G01N033/569

US Classification:

435 5, 435 6, 435 71, 435 72, 435 75, 436501, 436518, 436524, 436528, 436529, 436530, 436534, 436536, 436805, 436806

Abstract:

A method for the detection of an analyte of interest in a sample, which method comprises the steps of:.

US Patent:

52472434, Sep 21, 1993

Filed:

Aug 14, 1991

Appl. No.:

7/744890

Inventors:

Lee O. Hall - Gaithersburg MD
Glenn Zoski - Rockville MD
Surendera K. Tyagi - Gaithersburg MD

Assignee:

Igen, Inc. - Rockville MD

International Classification:

G01N 2700

US Classification:

324 711

Abstract:

A method and apparatus for triggering and measuring electrochemiluminescent phenomena using a voltage waveform applied at the voltammetric working electrode which improves the precision and accuracy of measurements. This waveform has a decreasing scan rate in the range of voltages for which electrochemiluminescence is triggered and is substantially sinusoidal in shape in this range. The waveform results from locating the reference electrode of a potentiostat in close potential proximity to its counter electrode, and applying a uniform scanning voltage waveform at the reference electrode. The waveform also can be synthesized digitally, converted to analog form, and applied directly to the working electrode with the reference electrode in close potential proximity to the working electrode.

US Patent:

50680889, Nov 26, 1991

Filed:

Mar 17, 1989

Appl. No.:

7/325459

Inventors:

Lee O. Hall - Gaithersburg MD
Glenn Zoski - Rockville MD
Surendera K. Tyagi - Gaithersburg MD

Assignee:

Igen, Inc. - Rockville MD

International Classification:

G01N 2176
H01J 162
H03K 400

US Classification:

422 52

Abstract:

A method and apparatus for triggering and measuring electrochemiluminescent phenomena using a voltage waveform applied at the voltammetric working electrode which improves the precision and accuracy of measurements. This waveform has a decreasing scan rate in the range of voltages for which electrochemiluminescence is triggered and is substantially sinusoidal in shape in this range. The waveform results from locating the reference electrode of a potentiostat in close potential proximity to its counter electrode, and applying a uniform scanning voltage waveform at the reference electrode. The waveform also can be synthesized digitally, converted to analog form, and applied directly to the working electrode with the reference electrode in close potential proximity to the working electrode.

US Patent:

51478064, Sep 15, 1992

Filed:

Sep 27, 1991

Appl. No.:

7/773971

Inventors:

Ralph A. Kamin - Gaithersburg MD
Lee O. Hall - Gaithersburg MD
Jonathan K. Leland - Gaithersburg MD

Assignee:

Igen, Inc. - Rockville MD

International Classification:

G01N 2176

US Classification:

436149

Abstract:

A method and apparatus for conducting electrochemiluminescence (ECL) measurements which control the initial conditions relating to the surface state of a triggering working electrode by reproducibly creating and maintaining a favorable surface condition so as to enhance the precision and detection limit of the measurements. Assays are performed with ECL detection in a flow-through cell environment and the precision and detection limit are enhanced by alternating initialization and measurement steps.

US Patent:

52961915, Mar 22, 1994

Filed:

May 4, 1993

Appl. No.:

8/057682

Inventors:

Lee O. Hall - Gaithersburg MD
Glenn Zoski - Rockville MD
Surendera K. Tyagi - Gaithersburg MD

Assignee:

IGEN, Inc. - Rockville MD

International Classification:

G01N 2176
G01N 2700

US Classification:

422 52

Abstract:

A method and apparatus for triggering and measuring electrochemiluminescent phenomena using a voltage waveform applied at the voltammetric working electrode which improves the precision and accuracy of measurements. This waveform has a decreasing scan rate in the range of voltages for which electrochemiluminescence is triggered and is substantially sinusoidal in shape in this range. The waveform results from locating the reference electrode of a potentiostat in close potential proximity to its counter electrode, and applying a uniform scanning voltage waveform at the reference electrode. The waveform also can be synthesized digitally, converted to analog form, and applied directly to the working electrode with the reference electrode in close potential proximity to the working electrode.