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Lee F Kuyper

age ~71

from Durham, NC

Lee Kuyper Phones & Addresses

  • 6 Plowlan Pl, Durham, NC 27707

Us Patents

  • Substituted Oxidole Derivatives As Protein Tyrosine And As Protein Serine/Threonine Kinase Inhibitors

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  • US Patent:
    6369086, Apr 9, 2002
  • Filed:
    Mar 4, 1999
  • Appl. No.:
    09/262351
  • Inventors:
    Stephen Thomas Davis - Durham NC
    Scott Howard Dickerson - Chapel Hill NC
    Philip Anthony Harris - Raleigh NC
    Lee Frederick Kuyper - Durham NC
    Karen Elizabeth Lackey - Hillsborough NC
    Michael Joseph Luzzio - Durham NC
    James Marvin Veal - Cary NC
    Duncan Herrick Walker - Summit NJ
  • Assignee:
    SmithKline Beecham Corporation - Philadelphia PA
  • International Classification:
    A61K 314439
  • US Classification:
    514338, 5462701, 546256, 548122, 548151, 544333, 514272, 514291, 514365, 514366
  • Abstract:
    The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit protein tyrosine kinase and protein serine/threonine kinase inhibition, and which are useful in inhibiting tumor growth via inhibition of such kinases as well as protecting a patient undergoing chemotherapy from chemotherapy induced alopecia.
  • Substituted Oxindole Derivatives As Protein Tyrosine Kinase And As Protein Serine/Threonine Kinase Inhibitors

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  • US Patent:
    6387919, May 14, 2002
  • Filed:
    Jun 6, 2000
  • Appl. No.:
    09/486960
  • Inventors:
    Stephen Thomas Davis - Durham NC
    Scott Howard Dickerson - Chapel Hill NC
    Philip Anthony Harris - Raleigh NC
    Lee Frederick Kuyper - Durham NC
    Michael Joseph Luzzio - Groton CT
    James Marvin Veal - Apex NC
    Duncan Herrick Walker - Summit NJ
  • Assignee:
    Glaxo Wellcome Inc. - Research Triangle Park NC
  • International Classification:
    A61K 314045
  • US Classification:
    514291, 514366, 546 80, 548122, 548126, 548150, 548151
  • Abstract:
    Compounds of formula (I): wherein X is N, CH, CCF , or C(C aliphatic); R is sulfonic acid, C aliphatic-sulfonyl, sulfonyl-C aliphatic, C aliphatic-sulfonyl-C aliphatic, C aliphatic-amino, R -sulfonyl, R sulfonyl-C aliphatic, R -aminosulfonyl, R -aminosulfonyl-C aliphatic, R -sulfonylamino, R -sulfonylamino-C aliphatic, aminosulfonylamino, di-C aliphatic amino, di-C aliphatic aminocarbonyl, di-C aliphatic aminosulfonyl, di-C aliphatic amino, di-C aliphatic aminocarbonyl, di-C aliphatic aminosulfonyl-C aliphatic, (R ) -Arylamino, (R ) -Arylsulfonyl, (R ) -Aryl-aminosulfonyl, (R ) -Aryl-sulfonylamino, Het-amino, Het-sulfonyl, Het-aminosulfonyl, aminoiminoamino, or aminoiminoaminosulfonyl, R is hydrogen; and further wherein R and R are optionally joined to form a fused ring, pharmaceutical formulations comprising them and their use in therapy, especially in the treatment of diseases mediated by CDK2 activity, such as alopecia induced by cancer chemotherapy or radiotherapy.
  • Substituted Oxindole Derivatives As Protein Tyrosine Kinase And As Protein Serine/Threonine Kinase Inhibitors

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  • US Patent:
    6541503, Apr 1, 2003
  • Filed:
    Aug 8, 2001
  • Appl. No.:
    09/924431
  • Inventors:
    Stephen Thomas Davis - Durham NC
    Scott Howard Dickerson - Chapel Hill NC
    Stephen Vernon Frye - Durham NC
    Philip Anthony Harris - Raleigh NC
    Lee Frederick Kuyper - Durham NC
    Karen Elizabeth Lackey - Hillsborough NC
    Michael Joseph Luzzio - Groton CT
    James Marvin Veal - Apex NC
    Duncan Herrick Walker - Summit NJ
  • Assignee:
    SmithKline Beecham Corporation - Philadelphia PA
  • International Classification:
    A61K 31429
  • US Classification:
    514414, 514419, 514426, 548452, 548483, 548484, 5462771, 5462781, 544111
  • Abstract:
    Compounds of formula (I): wherein X is N, CH, CCF , or C(C aliphatic); R is sulfonic acid, C aliphatic-sulfonyl, sulfonyl-C aliphatic, C aliphatic-sulfonyl-C aliphatic, C aliphatic-amino, R -sulfonyl, R sulfonyl-C aliphatic, R -aminosulfonyl, R -aminosulfonyl-C aliphatic, R -sulfonylamino, R -sulfonylamino-C aliphatic, aminosulfonylamino, di-C aliphatic amino, di-C aliphatic aminocarbonyl, di-C aliphatic aminosulfonyl, di-C aliphatic amino, di-C aliphatic aminocarbonyl, di-C aliphatic aminosulfonyl-C aliphatic, (R ) -Arylamino, (R ) -Arylsulfonyl, (R ) -Aryl-aminosulfonyl, (R ) -Aryl-sulfonylamino, Het-amino, Het-sulfonyl, Het-aminosulfonyl, aminoiminoamino, or aminoiminoaminosulfonyl, R is hydrogen; and further wherein R and R are optionally joined to form a fused ring, pharmaceutical formulations comprising them and their use in therapy, especially in the treatment of diseases mediated by CDK2 activity, such as alopecia induced by cancer chemotherapy or radiotherapy.
  • Substituted Aza-Oxindole Derivatives

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  • US Patent:
    6624171, Sep 23, 2003
  • Filed:
    Aug 28, 2001
  • Appl. No.:
    09/914393
  • Inventors:
    Philip Anthony Harris - Durham NC
    Lee Frederick Kuyper - Durham NC
    Karen Elizabeth Lackey - Durham NC
    James Marvin Veal - Durham NC
  • Assignee:
    SmithKline Beecham Corporation - Philadelphia PA
  • International Classification:
    A61K 31407
  • US Classification:
    514293, 5142292, 514299, 514366, 514411, 514418, 514426, 546 79, 546 83, 546113, 546151, 548427, 548430, 548431, 548452, 548465, 548486, 548490, 544 98, 544111, 544359, 544368, 544336, 544242, 544301, 544179, 544180, 544 59, 544 61
  • Abstract:
    Substituted aza-oxindole derivatives useful as cyclin dependent kinase 11 inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e. g. , alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiation therapy in a patient receiving such therapy.
  • Substituted Aza-Oxindole Derivatives

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  • US Patent:
    6815439, Nov 9, 2004
  • Filed:
    Sep 23, 2003
  • Appl. No.:
    10/669400
  • Inventors:
    Philip Anthony Harris - Durham NC
    Lee Frederick Kuyper - Durham NC
    Karen Elizabeth Lackey - Durham NC
    James Marvin Veal - Durham NC
  • Assignee:
    SmithKline Beecham Corporation - Philadelphia PA
  • International Classification:
    A61K 3133
  • US Classification:
    514183, 5142292, 514299, 514418, 514412, 514430, 546112, 546113, 548452, 548453, 548465
  • Abstract:
    Substituted aza-oxindole derivatives useful as cyclin dependent kinase II inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e. g. , alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiation therapy in a patient receiving such therapy.
  • Oxindole Derivatives

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  • US Patent:
    6964977, Nov 15, 2005
  • Filed:
    Aug 23, 2001
  • Appl. No.:
    10/362739
  • Inventors:
    Philip Anthony Harris - Durham NC,
    Robert N Hunter - Durham NC,
    Lee Frederick Kuyper - Durham NC,
    Karen Elizabeth Lackey - Durham NC,
    Michael Robert Peel - Durham NC,
  • Assignee:
    SmithKline Beecham Corporation - Philadelphia PA
  • International Classification:
    A61K031/415
  • US Classification:
    514387, 514383, 514364, 514418, 514339, 546196, 548131, 5482664, 5483051, 548486
  • Abstract:
    The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
  • Substituted Oxindole Derivatives As Tyrosine Kinase Inhibitors

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  • US Patent:
    7071217, Jul 4, 2006
  • Filed:
    Aug 23, 2001
  • Appl. No.:
    10/362743
  • Inventors:
    Scott Howard Dickerson - Durham NC,
    Robert N Hunter - Durham NC,
    Lee Frederick Kuyper - Durham NC,
    Karen Elizabeth Lackey - Durham NC,
    Michael J. Luzzio - Noank CT,
  • Assignee:
    SmithKline Beecham Corporation - Philadelphia PA
  • International Classification:
    A61K 31/44
    C07D 401/02
  • US Classification:
    514339, 5462777, 548138, 548483, 548484, 514363, 514418
  • Abstract:
    The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis, In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
  • Substituted Oxindole Derivatives As Protein Tyrosine And As Protein Serine/Threonine Kinase Inhibitors And Compositions And Methods Of Treating Chemotherapy And Radiation Therapy Side Effects

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  • US Patent:
    7105529, Sep 12, 2006
  • Filed:
    Nov 30, 2001
  • Appl. No.:
    09/999331
  • Inventors:
    Stephen Thomas Davis - Durham NC,
    Scott Howard Dickerson - Chapel Hill NC,
    Stephen Vernon Frye - Durham NC,
    Philip Anthony Harris - Raleigh NC,
    Lee Frederick Kuyper - Durham NC,
    Karen Elizabeth Lackey - Hillsborough NC,
    Michael Joseph Luzzio - Groton CT,
    James Marvin Veal - Apex NC,
    Duncan Herrick Walker - Summit NJ,
  • Assignee:
    SmithKline Beecham Corporation - Philadelphia PA
  • International Classification:
    A61K 31/505
    A61K 31/44
    A61K 31/425
  • US Classification:
    514272, 291365, 291366
  • Abstract:
    Compounds of formula (I): wherein X is N, CH, CCF, or C(Caliphatic); Ris sulfonic acid, Caliphatic-sulfonyl, sulfonyl-Caliphatic, Caliphatic-sulfonyl-Caliphatic, Caliphatic-amino, R-sulfonyl, Rsulfonyl-Caliphatic, R-aminosulfonyl, R-aminosulfonyl-Caliphatic, R-sulfonylamino, R-sulfonylamino-Caliphatic, aminosulfonylamino, di-Caliphatic amino, di-Caliphatic aminocarbonyl, di-Caliphatic aminosulfonyl, di-Caliphatic amino, di-Caliphatic aminocarbonyl, di-Caliphatic aminosulfonyl-Caliphatic, (R)-Arylamino, (R)-Arylsulfonyl, (R)-Aryl-aminosulfonyl, (R)-Aryl-sulfonylamino, Het-amino, Het-sulfonyl, Het-aminosulfonyl, aminoiminoamino, or aminoiminoaminosulfonyl, Ris hydrogen; and further wherein Rand Rare optionally joined to form a fused ring, pharmaceutical formulations comprising them and their use in therapy, especially in the treatment of diseases mediated by CDK2 activity, such as alopecia induced by cancer chemotherapy or radiotherapy.

Resumes

Lee Kuyper Photo 1

Lee Kuyper

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Location:
Raleigh-Durham, North Carolina Area
Industry:
Pharmaceuticals
Lee Kuyper Photo 2

Retired

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Location:
Durham, North Carolina
Industry:
Pharmaceuticals
Work:
GlaxoSmithKline Jul 1977 - Jul 2011
Retired

Vehicle Records

  • Lee Kuyper

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  • Address:
    6 Plowlan Pl, Durham, NC 27707
  • VIN:
    JTDKB20U973203947
  • Make:
    TOYOTA
  • Model:
    PRIUS
  • Year:
    2007

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Lee Kuyper

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Sherrie Lee Kuyper

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