Lei Tang

US Patent:

20060223075, Oct 5, 2006

Filed:

Apr 22, 2005

Appl. No.:

11/112926

Inventors:

Lisa Davis - Albuquerque NM, US
Lei Tang - Albuquerque NM, US

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

The present invention provides unique sequence probes, methods for generating them, and methods for using unique sequence probes in hybridization assays.

US Patent:

20120301885, Nov 29, 2012

Filed:

Feb 24, 2011

Appl. No.:

13/576142

Inventors:

Lei Tang - Oro Valley AZ, US
Hong Ni - Austin TX, US
Heather Noelle Lewis - Oro Valley AZ, US

International Classification:

G01N 21/78
C12Q 1/68

US Classification:

435 611

Abstract:

The present invention relates to methods and systems for analyzing chromosomes, and in particular to methods and systems for simultaneously performing banding and in situ hybridization on metaphase chromosomes.

US Patent:

20130196880, Aug 1, 2013

Filed:

Jan 22, 2013

Appl. No.:

13/746455

Inventors:

Heather Lewis - Tucson AZ, US
Lei Tang - Oro Valley AZ, US
Lizhen Pang - Tucson AZ, US
Hong Ni - Austin TX, US

Assignee:

VENTANA MEDICAL SYSTEMS, INC. - Tucson AZ

International Classification:

C40B 40/06
C40B 40/12
C40B 40/10
C12Q 1/68
G01N 33/68

US Classification:

506 16, 506 18

Abstract:

Disclosed herein are devices for the detection of target molecules and methods for their use and production. The disclosed devices may include optically decipherable patterns that facilitate an understanding of binding events between a target molecule and a detection molecule. In one example, a device includes a macroscopic pattern constructed using microscopic elements that can be chromogenically developed to memorialize a binding event. In another example, a device includes characters that can be chromogenically developed using an automated slide staining instrument to memorialize a binding event.

US Patent:

20210374962, Dec 2, 2021

Filed:

Mar 30, 2021

Appl. No.:

17/218087

Inventors:

- Tucson AZ, US
- Baltimore MD, US
- New York NY, US
Lei TANG - Tucson AZ, US
Xiangxue WANG - Tucson AZ, US
Wenjun ZHANG - Tucson AZ, US
Robert ANDERS - Baltimore MD, US
Luis DIAZ - New York NY, US

International Classification:

G06T 7/00
G16H 10/40
G16H 30/20
G16H 30/40
G16H 50/20
G16H 50/70
G16H 50/50
G16H 20/10
C07K 16/28

Abstract:

A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.

US Patent:

20210002726, Jan 7, 2021

Filed:

May 20, 2020

Appl. No.:

16/879228

Inventors:

- Tucson AZ, US
Antony Hubbard - Tucson AZ, US
Donald Johnson - Tucson AZ, US
Brian Kelly - Tucson AZ, US
Taylor Shingler - Tucson AZ, US
Lei Tang - Oro Valley AZ, US
Wenjun Zhang - Tucson AZ, US

International Classification:

C12Q 1/6886
C12Q 1/6841

Abstract:

Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

US Patent:

20190094242, Mar 28, 2019

Filed:

Sep 6, 2018

Appl. No.:

16/123750

Inventors:

- Tucson AZ, US
Antony Hubbard - Tucson AZ, US
Eric May - Oro Valley AZ, US
Lei Tang - Oro Valley AZ, US
Tsu-Shuen Tsao - Tucson AZ, US
Wenjun Zhang - Tucson AZ, US

International Classification:

G01N 33/68
C07K 16/28
C07K 16/18

Abstract:

The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

US Patent:

20180095082, Apr 5, 2018

Filed:

Oct 9, 2017

Appl. No.:

15/728444

Inventors:

- Tucson AZ, US
Tobin Jones - Tucson AZ, US
Lei Tang - Oro Valley AZ, US
Wenjun Zhang - Tucson AZ, US

International Classification:

G01N 33/543
G01N 1/31

Abstract:

Methods, systems, compositions, and thermochemical processes for inactivating proteinaceous binding entities (PBEs) such as antibodies in between staining cycles for preventing cross-reactivity in subsequent staining cycles. The thermochemical methods, compositions, or systems may feature incubating a sample in a solution comprising a buffer at a temperature sufficient to reduce or eliminate further detectability of the PBE. The methods, compositions, and systems may be beneficial for automated assays in automated staining devices that are adapted to dispense buffers and reagents and to heat samples to various temperatures.

US Patent:

20170152573, Jun 1, 2017

Filed:

Feb 6, 2017

Appl. No.:

15/425810

Inventors:

- Tucson AZ, US
Antony Hubbard - Tucson AZ, US
Lei Tang - Oro Valley AZ, US
Wenjun Zhang - Tucson AZ, US

International Classification:

C12Q 1/68

Abstract:

Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization and the ability to achieve specific hybridization without blocking DNA.