Lei Zhang

US Patent:

8617592, Dec 31, 2013

Filed:

May 3, 2012

Appl. No.:

13/463662

Inventors:

Shaoyi Jiang - Redmond WA, US
Zhiqiang Cao - Somerville MA, US
Hong Xue - Pleasanton CA, US
Lei Zhang - Seattle WA, US

Assignee:

University of Washington through its Center for Commercialization - Seattle WA

International Classification:

A61K 9/127
A61K 9/107

US Classification:

424450, 5147721, 525419

Abstract:

Zwitterionic block copolymers and zwitterionic conjugates that advantageously self-assemble into particles, particles assembled from the zwitterionic block copolymers and zwitterionic conjugates, pharmaceutical compositions that include the self-assembled particles, and methods for delivering therapeutic and diagnostic agents using the particles.

US Patent:

20110097277, Apr 28, 2011

Filed:

Nov 8, 2010

Appl. No.:

12/941938

Inventors:

Shaoyi Jiang - Redmond WA, US
Guangwei Jia - Tianjin, CN
Hong Xue - Seattle WA, US
Wei Yang - Seattle WA, US
Lei Zhang - Seattle WA, US

Assignee:

University of Washington - Seattle WA

International Classification:

A61K 49/18
A61K 9/50
C08F 8/00
B82Y 5/00

US Classification:

424 9322, 424497, 5253302, 525123, 525301, 977762, 977774, 977742

Abstract:

Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels.

US Patent:

20110207622, Aug 25, 2011

Filed:

Feb 10, 2011

Appl. No.:

13/025130

Inventors:

David T. WONG - Beverly Hills CA, US
Lei Zhang - Los Angeles CA, US
Hua Xiao - Irvine CA, US
Hui Zhou - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C40B 30/04
C12Q 1/68
C40B 30/00
C12Q 1/02
G01N 33/566
G01N 21/64
C07K 17/00
C07H 21/00
G01N 33/48
H01J 49/26

US Classification:

506 9, 435 614, 435 612, 506 7, 435 29, 435 71, 436501, 435 613, 5303911, 536 2433, 435 792, 73 6143, 250282

Abstract:

Presented herein are biomarkers related to lung cancer. The presently identified salivary biomarkers create the basis for a lung cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed lung cancer assay in clinical, diagnostic and therapeutic uses is also included.

US Patent:

20110212851, Sep 1, 2011

Filed:

Feb 10, 2011

Appl. No.:

13/025110

Inventors:

David T. WONG - Beverly Hills CA, US
Lei Zhang - Los Angeles CA, US
Hua Xiao - Irvine CA, US
Hui Zhou - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C40B 30/04
C12Q 1/32
C12Q 1/527
C12Q 1/68
C40B 30/00
G01N 33/573
G01N 33/566
G01N 21/64
C12Q 1/02
C07K 17/00
C07H 21/00
G01N 33/48
H01J 49/26

US Classification:

506 9, 435 26, 435 4, 435 612, 506 7, 436501, 435 74, 435 792, 435 71, 435 29, 5303911, 536 2433, 73 6143, 250282

Abstract:

Presented herein are biomarkers related to breast cancer. The presently identified salivary biomarkers create the basis for a breast cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed breast cancer assay in clinical, diagnostic and therapeutic uses is also included.

US Patent:

20120196764, Aug 2, 2012

Filed:

Jun 25, 2010

Appl. No.:

13/379341

Inventors:

Lei Zhang - Los Angeles CA, US
David T. Wong - Beverly Hills CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C40B 30/04
C12Q 1/68

US Classification:

506 9, 435 612

Abstract:

The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing pancreatic cancer and distinguishing between pancreatic cancer and chronic pancreatitis. The present invention additionally provides kits that find use in the practice of the methods of the invention.

US Patent:

20220391621, Dec 8, 2022

Filed:

Jun 4, 2021

Appl. No.:

17/339413

Inventors:

- Redmond WA, US
Qiankun LIU - Hefei, CN
Lu YUAN - Redmond WA, US
Lei ZHANG - Bellevue WA, US

Assignee:

Microsoft Technology Licensing, LLC - Redmond WA

International Classification:

G06K 9/00
G06K 9/46
G06K 9/32
G06T 7/20
G06N 3/04
G06K 9/62

Abstract:

A system for tracking a target object across a plurality of image frames. The system comprises a logic machine and a storage machine. The storage machine holds instructions executable by the logic machine to calculate a trajectory for the target object over one or more previous frames occurring before a target frame. Responsive to assessing no detection of the target object in the target frame, the instructions are executable to predict an estimated region for the target object based on the trajectory, predict an occlusion center based on a set of candidate occluding locations for a set of other objects within a threshold distance of the estimated region, each location of the set of candidate occluding locations overlapping with the estimated region, and automatically estimate a bounding box for the target object in the target frame based on the occlusion center.

US Patent:

20220318541, Oct 6, 2022

Filed:

Apr 5, 2021

Appl. No.:

17/222879

Inventors:

- Redmond WA, US
Yinpeng CHEN - Sammamish WA, US
Bin XIAO - Bellevue WA, US
Dongdong CHEN - Bellevue WA, US
Mengchen LIU - Redmond WA, US
Lu YUAN - Redmond WA, US
Lei ZHANG - Bellevue WA, US

International Classification:

G06K 9/00
G06T 3/00
G06T 3/40
G02B 27/01

Abstract:

Systems and methods for object detection generate a feature pyramid corresponding to image data, and rescaling the feature pyramid to a scale corresponding to a median level of the feature pyramid, wherein the rescaled feature pyramid is a four-dimensional (4D) tensor. The 4D tensor is reshaped into a three-dimensional (3D) tensor having individual perspectives including scale features, spatial features, and task features corresponding to different dimensions of the 3D tensor. The 3D tensor is used with a plurality of attention layers to update a plurality of feature maps associated with the image data. Object detection is performed on the image data using the updated plurality of feature maps.

US Patent:

20220318574, Oct 6, 2022

Filed:

Jun 17, 2022

Appl. No.:

17/843270

Inventors:

- Redmond WA, US
Maria ZONTAK - Seattle WA, US
Tucker Cunningham BURNS - Issaquah WA, US
Apar SINGHAL - Seattle WA, US
Lei ZHANG - Bellevue WA, US
Irit OFER - Kfar-Saba, IL
Avner LEVI - Kiryat Ono, IL
Haim SABO - Petah Tikva, IL
Ika BAR-MENACHEM - Herzliya, IL
Eylon AMI - Givataayim, IL
Ella BEN TOV - Tel-Aviv, IL
Anika ZAMAN - Redmond WA, US

International Classification:

G06K 9/62
G06V 20/40

Abstract:

The technology described herein is directed to systems, methods, and software for indexing video. In an implementation, a method comprises identifying one or more regions of interest around target content in a frame of the video. Further, the method includes identifying, in a portion of the frame outside a region of interest, potentially empty regions adjacent to the region of interest. The method continues with identifying at least one empty region of the potentially empty regions that satisfies one or more criteria and classifying at least the one empty region as a negative sample of the target content. In some implementations, the negative sample of the target content in a set of negative samples of the target content, with which to train a machine learning model employed to identify instances of the target content.