Lei E Zhang

US Patent:

6359288, Mar 19, 2002

Filed:

Apr 22, 1998

Appl. No.:

09/064242

Inventors:

Jackie Y. Ying - Winchester MA
Zhibo Zhang - Cambridge MA
Lei Zhang - Cambridge MA
Mildred S. Dresselhaus - Arlington MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

H01L 2915

US Classification:

257 14, 257 9, 257 28, 205202, 428606, 428614, 428629, 4284722

Abstract:

An array of nanowires having a relatively constant diameter and techniques and apparatus for fabrication thereof are described. In one embodiment, a technique for melting a material under vacuum and followed by pressure injection of the molten material into the pores of a porous substrate produces continuous nanowires. In another embodiment, a technique to systematically change the channel diameter and channel packing density of an anodic alumina substrate includes the steps of anodizing an aluminum substrate with an electrolyte to provide an anodic aluminum oxide film having a pore with a wall surface composition which is different than aluminum oxide and etching the pore wall surface with an acid to affect at least one of the surface properties of the pore wall and the pore wall composition.

US Patent:

6577430, Jun 10, 2003

Filed:

May 14, 2001

Appl. No.:

09/853713

Inventors:

Guanghai Jin - Woburn MA 01801
Lei Zhang - Acton MA
Jing Zhao - Winchester MA

Assignee:

Guanghai Jin - Woburn MA

International Classification:

G02F 109

US Classification:

359280, 359281, 359320, 359324, 359484, 385 16, 385 22, 385 11, 385 18, 343756

Abstract:

The present invention provides improved optical switches in which no mechanical movement is required to direct optical pathways between plural fiber ports and light transmission is bi-directional. Advantageously, the inventive switches permit bi-directional light transmission. The inventive switches also incorporate light bending devices to allow two fibers to be coupled to the light beams using a single lens for compactness. In the inventive switch, an optical signal is spatially split into two polarized beams by a birefringent element, which passes through a polarization rotation device that comprises waveplates, walk-off elements, and an electrically controllable polarization rotator, and recombine into an output fiber, achieving polarization independent operation. The switches of the present invention rely on electro-magnetically or electro-optically switching the beam polarizations from one state to another to rapidly direct the light path.

US Patent:

7705307, Apr 27, 2010

Filed:

Feb 27, 2007

Appl. No.:

11/711275

Inventors:

Jing Zhao - Winchester MA, US
Lei Zhang - Acton MA, US

Assignee:

Agiltron Corporation - Woburn MA

International Classification:

B41J 2/05

US Classification:

2503381

Abstract:

A radiation detector comprises an infrared radiation sensing micro mirror array, where each micro mirror is supported with a deformable cantilever beam having an organic layer for increased dynamic range. The radiation detector includes two or more sources of optical radiation for irradiating the micro mirror array, an image sensor array for receiving optical reflection from the micro mirror array, and an aperture plate for (i) spatially restricting optical radiation reaching the micro mirror array and (ii) spatially restricting reflected optical reflection reaching the image sensor array.

US Patent:

7705309, Apr 27, 2010

Filed:

Apr 8, 2008

Appl. No.:

12/082007

Inventors:

Guanghai Jin - Boxborough MA, US
Lei Zhang - Acton MA, US
Jing Zhao - Winchester MA, US

Assignee:

Agiltron Corporation - Woburn MA

International Classification:

H01L 25/00

US Classification:

2503381, 250332, 250352, 250330, 25037008, 25037001

Abstract:

A mechanical-optical transducer comprises a readout illumination source providing light having different wavelengths or different polarization states; an image sensor array for sensing the light from the readout illumination source; and a mechanical-optical device including sensing pixels whose optical property change in response to incident thermal infrared radiation, the mechanical-optical device having a reflective surface disposed to selectively reflect light from the readout illumination source to the image sensor array.

US Patent:

20030165849, Sep 4, 2003

Filed:

Nov 27, 2001

Appl. No.:

09/996139

Inventors:

Biliang Zhang - Shrewsbury MA, US
Zhiyong Cui - Worcester MA, US
Lei Zhang - Agawam MA, US

International Classification:

C12Q001/68
C07H021/02
C12P019/34

US Classification:

435/006000, 435/091200, 536/023100

Abstract:

Methods for synthesizing RNA molecules whose 5′-terminus comprises a thiol group are disclosed. The present invention discloses the formation of 5′-HS-PEG-GMP-RNA and 5′-GMPS-RNA which upon alkaline phosphatase treatment, independently lead to a 5′-HS-RNA molecule.

US Patent:

20100144730, Jun 10, 2010

Filed:

Jul 2, 2007

Appl. No.:

12/307104

Inventors:

Kenneth Egnard Lind - Arlington MA, US
Kathy Cao - Sunnyvale CA, US
Edward Yin-shiang Lin - Chestnut Hill MA, US
Thinh Ba Nguyen - Santa Clara CA, US
Bradley T. Tangonan - San Francisco CA, US
Daniel A. Erlanson - San Francisco CA, US
Kevin Guckian - Marlborough MA, US
Robert Lowell Simmons - San Francisco CA, US
Lihong Sun - Lexington MA, US
Stig Hansen - Kensington CA, US
Nuzhat Pathan - San Diego CA, US
Lei Zhang - Cheshire CT, US

Assignee:

Sunesis Phamaceuticals - South San Francisco CA
Biogen IDEC,INC - Cambrige MA

International Classification:

A61K 31/437
C07D 471/04
C07D 487/04
C07D 413/14
A61K 31/519
A61K 31/5377
A61P 35/00

US Classification:

5142345, 546113, 546119, 544262, 544127, 514300, 514303, 5142621

Abstract:

The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.

US Patent:

20120192301, Jul 26, 2012

Filed:

Dec 15, 2011

Appl. No.:

13/327558

Inventors:

Rudolf Jaenisch - Brookline MA, US
Josee Laganiere - El Cerrito CA, US
Frank Soldner - Cambridge MA, US
Lei Zhang - Davis CA, US

International Classification:

A01K 67/027
C12N 15/85
C12P 19/34
C12N 9/96
C12N 15/62

US Classification:

800 21, 435188, 536 232, 435 911, 435455

Abstract:

Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.

US Patent:

20130184294, Jul 18, 2013

Filed:

Sep 7, 2011

Appl. No.:

13/822669

Inventors:

Isao Sakurada - Gotemb, JP
Lei Zhang - Auburndale MA, US

Assignee:

Pfizer Inc. - Groton CT

International Classification:

C07D 471/04
A61K 45/06
A61K 31/519

US Classification:

5142594, 544282

Abstract:

The present invention relates to compounds of Formula I as described herein or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof and methods of treating a disease, disorder, or condition of the central nervous system, including bipolar disorder, depressive disorders, anxiety disorders, cognitive disorders, pain disorders, urogenital disorders, and epilepsy, among the other diseases, disorders or conditions discussed herein as mono-therapy or in combination with another active pharmaceutical ingredient.