Lei Karen Zhang

US Patent:

7220865, May 22, 2007

Filed:

Mar 11, 2005

Appl. No.:

11/078862

Inventors:

Yuhpyng L Chen - Waterford CT, US
Lei Zhang - Groton CT, US

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D 261/14
A61K 31/42

US Classification:

548246, 514378

Abstract:

The present invention relates to compounds of the Formula I.

US Patent:

7244757, Jul 17, 2007

Filed:

Mar 11, 2005

Appl. No.:

11/078861

Inventors:

Yuhpyng L. Chen - Waterford CT, US
Lei Zhang - Groton CT, US

Assignee:

Pfizer Inc - New York NY

International Classification:

A61K 31/415
A61K 31/4155
C07D 231/40

US Classification:

514407, 5483717, 5483657, 5483644

Abstract:

The present invention relates to compounds of the Formula.

US Patent:

7468386, Dec 23, 2008

Filed:

Jul 5, 2007

Appl. No.:

11/773831

Inventors:

Yuhpyng L. Chen - Waterford CT, US
Lei Zhang - Groton CT, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 31/415
A61K 31/4155
C07D 231/40

US Classification:

514407, 5483717, 5483657, 5483644

Abstract:

The present invention relates to compounds of the Formula.

US Patent:

7582645, Sep 1, 2009

Filed:

Oct 8, 2004

Appl. No.:

10/573227

Inventors:

Julie A. Dixon - Bethany CT, US
Dhanapalan Nagarathnam - Bethany CT, US
Lei Zhang - Hamden CT, US
Chunguang Wang - Hamden CT, US
Lin Yi - Milford CT, US
Yuanwei Chen - North Haven CT, US
Jianqing Chen - New Haven CT, US
Brian Bear - Oceanside CA, US
Michael Brands - Wuppertal, DE
Alexander Hillisch - Velbert, DE
Donald Bierer - Bethany CT, US
Ming Wang - Milford CT, US
Wenlang Fu - Milford CT, US
Martin F. Hentemann - Hamden CT, US
Ann-Marie Bullion - Milford CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

C07D 239/48
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
C07D 409/14
C07D 413/14
A61K 31/506
A61K 31/505
A61P 35/00

US Classification:

514269, 514275, 544323, 544324, 544326, 544328, 544329

Abstract:

Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R, G, G′, and G″ represent substituent groups and Rrepresents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

US Patent:

7582646, Sep 1, 2009

Filed:

Mar 10, 2005

Appl. No.:

11/078681

Inventors:

Julie A. Dixon - Bethany CT, US
Dhanapalan Nagarathnam - Bethany CT, US
Lei Zhang - Hamden CT, US
Chunguang Wang - Hamden CT, US
Lin Yi - Milford CT, US
Yuanwei Chen - North Haven CT, US
Jianqing Chen - New Haven CT, US
Brian R. Bear - Oceanside CA, US
Michael Brands - Hamden CT, US
Alexander Hillisch - Velbert, DE
Donald Bierer - Bethany CT, US
Ming Wang - Milford CT, US
Wenlang Fu - Milford CT, US
Martin F. Hentemann - Hamden CT, US
Ann-Marie Bullion - Milford CT, US
Manoj Patel - Berlin CT, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

C07D 239/48
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
C07D 409/14
C07D 413/14
A61K 31/505
A61K 31/506
A61P 35/00

US Classification:

514269, 514275, 544323, 544324, 544326, 544328, 544329

Abstract:

Pyrimidine derivatives of formula (I).

US Patent:

7648986, Jan 19, 2010

Filed:

Apr 9, 2007

Appl. No.:

11/733045

Inventors:

Dhanapalan Nagarathnam - Bethany CT, US
Uday Khire - Hamden CT, US
Davoud Asgari - Plainsboro NJ, US
Jianxing Shao - Cheshire CT, US
Chunguang Wang - Hamden CT, US
Barry Hart - Mountain View CA, US
Olaf Weber - Woodbridge CT, US
Mark Lynch - Madison CT, US
Lei Zhang - Hamden CT, US
Lei Wang - New Haven CT, US

Assignee:

Bayer Healthcare LLC - Tarrytown NY

International Classification:

C07D 495/04
C07D 251/16
C07D 413/10
A61K 31/519
A61K 31/5377
A61K 31/53
A61K 31/497
A61K 31/496
A61K 31/498
A61P 9/12
A61P 9/10
A61P 35/04
A61P 11/06
C07D 401/12
C07D 401/14

US Classification:

5142342, 51425216, 514245, 5142601, 51425505, 51426411, 544117, 544211, 544278, 544284

Abstract:

Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e. g. , coronary heart disease.

US Patent:

7678804, Mar 16, 2010

Filed:

Mar 10, 2005

Appl. No.:

11/078681

Inventors:

Julie A. Dixon - Bethany CT, US
Dhanapalan Nagarathnam - Bethany CT, US
Lei Zhang - Hamden CT, US
Chunguang Wang - Hamden CT, US
Lin Yi - Milford CT, US
Yuanwei Chen - North Haven CT, US
Jianqing Chen - New Haven CT, US
Brian R. Bear - Oceanside CA, US
Michael Brands - Hamden CT, US
Alexander Hillisch - Velbert, DE
Donald Bierer - Bethany CT, US
Ming Wang - Milford CT, US
Wenlang Fu - Milford CT, US
Martin F. Hentemann - Hamden CT, US
Ann-Marie Bullion - Milford CT, US
Manoj Patel - Berlin CT, US

Assignee:

Bayer Healthcare LLC - Tarrytown NY

International Classification:

C07D 239/48
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
C07D 409/14
C07D 413/14
A61K 31/505
A61K 31/506
A61P 35/00

US Classification:

514269, 514275, 544323, 544324, 544326, 544328, 544329

Abstract:

Pyrimidine derivatives of formula (I).

US Patent:

7914665, Mar 29, 2011

Filed:

Nov 14, 2005

Appl. No.:

11/667236

Inventors:

Lei Zhang - Vienna VA, US
Elizabeth Stavens - Seabrook TX, US
Lisa I-Ching Yeh - Marlton NJ, US
Ian A. Cody - Annandale NJ, US
William J. Murphy - Baton Rouge LA, US
Thomas R. Palmer - Bethlehem PA, US

Assignee:

ExxonMobil Research and Engineering Company - Annandale NJ

International Classification:

C10G 29/20
C10G 47/02

US Classification:

208 28, 208 33, 208 36, 208108, 208 27

Abstract:

The invention relates to a process for preparing lube oil basestocks from lube oil boiling range feeds. More particularly, the present invention is directed toward a process wherein a wax containing feed is solvent dewaxed to produce at least a partially dewaxed lube oil boiling range stream, which is hydrodewaxed to produce a first lube basestock. The first lube basestock is added to an independently selected second lube basestock and additives to make a lubricating oil.