Lei Zhang

US Patent:

7705309, Apr 27, 2010

Filed:

Apr 8, 2008

Appl. No.:

12/082007

Inventors:

Guanghai Jin - Boxborough MA, US
Lei Zhang - Acton MA, US
Jing Zhao - Winchester MA, US

Assignee:

Agiltron Corporation - Woburn MA

International Classification:

H01L 25/00

US Classification:

2503381, 250332, 250352, 250330, 25037008, 25037001

Abstract:

A mechanical-optical transducer comprises a readout illumination source providing light having different wavelengths or different polarization states; an image sensor array for sensing the light from the readout illumination source; and a mechanical-optical device including sensing pixels whose optical property change in response to incident thermal infrared radiation, the mechanical-optical device having a reflective surface disposed to selectively reflect light from the readout illumination source to the image sensor array.

US Patent:

20030165849, Sep 4, 2003

Filed:

Nov 27, 2001

Appl. No.:

09/996139

Inventors:

Biliang Zhang - Shrewsbury MA, US
Zhiyong Cui - Worcester MA, US
Lei Zhang - Agawam MA, US

International Classification:

C12Q001/68
C07H021/02
C12P019/34

US Classification:

435/006000, 435/091200, 536/023100

Abstract:

Methods for synthesizing RNA molecules whose 5′-terminus comprises a thiol group are disclosed. The present invention discloses the formation of 5′-HS-PEG-GMP-RNA and 5′-GMPS-RNA which upon alkaline phosphatase treatment, independently lead to a 5′-HS-RNA molecule.

US Patent:

20220274986, Sep 1, 2022

Filed:

May 6, 2022

Appl. No.:

17/738074

Inventors:

- New York NY, US
Andrew Fensome - Harvard MA, US
Erik Alphie LaChapelle - Uncasville CT, US
Ethan Lawrence Fisher - Chester CT, US
Rayomand J. Unwalla - Bedford MA, US
Jun Xiao - East Lyme CT, US
Lei Zhang - Auburndale MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 471/04
A61K 31/437

Abstract:

The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

US Patent:

20220259197, Aug 18, 2022

Filed:

Mar 6, 2020

Appl. No.:

17/435125

Inventors:

- Cambridge MA, US
Kevin M. Guckian - Northborough MA, US
Jeffrey Vessels - Marlborough MA, US
Lei Zhang - Westford MA, US
Ryan Gianatassio - Everett MA, US
Edward Yin Shiang Lin - Ashland MA, US
Zhili Xin - Lexington MA, US

Assignee:

BIOGEN MA INC. - Cambridge MA

International Classification:

C07D 417/14
C07D 495/04

Abstract:

Described herein are compounds represented by formula (I) (I) or a pharmaceutically acceptable salt thereof, pharmaceutical comositions comprising the same and methods of preparing and using the same. The variables Ar, X, R, R, R, Y, Y, and Z are as defined herein.

US Patent:

20220204901, Jun 30, 2022

Filed:

Dec 29, 2021

Appl. No.:

17/564949

Inventors:

- Solon OH, US
Natalie Fekete - Marlborough MA, US
Lei Zhang - Shrewsbury MA, US
Rachel Z. Pytel - Newton MA, US
Robert Gordon Pleydon - Worcester MA, US

International Classification:

C12M 1/00
C12M 1/04
C12M 1/12

Abstract:

The disclosure relates generally to a cell culture apparatus and a cell culture method. One aspect of the disclosure is an oxygen-permeable bag comprising one or more polymer films defining a boundary of an interior compartment of the bag, each of the one or more polymer films comprising an inner layer adjacent the interior compartment of the bag, the inner layer comprising a fluoropolymer, and adhered to the inner layer, an outer layer comprising polymer; a first port formed in an exterior surface of the bag and in fluid communication with the interior compartment; a second port formed in an exterior surface of the bag and in fluid communication with the interior compartment; and contained in the interior compartment, a plurality of microcarriers.

US Patent:

20230113598, Apr 13, 2023

Filed:

Jul 21, 2022

Appl. No.:

17/814224

Inventors:

- Cardiff CA, US
- Cambridge MA, US
Kevin Guckian - Northborough MA, US
Gnanasambandam Kumaravel - Westford MA, US
Wen-Cheng Lee - Lexington MA, US
Edward Yin-Shiang Lin - Chestnut Hill MA, US
Daniel Scott - Weston MA, US
Lihong Sun - Lexington MA, US
Jermaine Thomas - Chelsea MA, US
Kurt Van Vloten - Bellingham MA, US
Deping Wang - Sharon MA, US
Lei Zhang - Westford MA, US
Daniel Erlanson - San Francisco CA, US

International Classification:

C07D 471/04
C07D 213/82
C07D 213/85
C07D 241/26
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/04
C07D 409/14
C07D 417/14
C07D 473/34
C07D 487/04
C07D 491/052
C07D 519/00
C07D 241/28
C07D 498/04
A61K 31/437
A61K 31/4439
A61K 31/444
A61K 31/452
A61K 31/4725
A61K 31/496
A61K 31/497
A61K 31/498
A61K 31/4985
A61K 31/517
A61K 31/519
A61K 31/53
A61K 31/5377
A61K 31/5383

Abstract:

The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

US Patent:

20230060003, Feb 23, 2023

Filed:

Oct 28, 2020

Appl. No.:

17/772646

Inventors:

- Cambridge MA, US
Kevin M. Guckian - Northborough MA, US
Lei Zhang - Westford MA, US
Zhili Xin - Cambridge MA, US
Jeffrey Vessels - Marlborough MA, US
Ryan Gianatassio - Everett MA, US

International Classification:

C07D 491/107
C07D 491/20
C07D 417/06

Abstract:

Described herein are compounds represented by formula (I) or formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R, R, R, R, R, R, Y, Y, D, E, G, G, n and p are as defined herein.

US Patent:

20210070752, Mar 11, 2021

Filed:

Jun 18, 2020

Appl. No.:

16/904890

Inventors:

- South San Francisco CA, US
- Cambridge MA, US
Kevin GUCKIAN - Northborough MA, US
Gnanasambandam KUMARAVEL - Westford MA, US
Wen-Cherng LEE - Lexington MA, US
Edward Yin-Shiang LIN - Chestnut Hill MA, US
Daniel SCOTT - Weston MA, US
Lihong SUN - Lexington MA, US
Jermaine THOMAS - Chelsea MA, US
Kurt VAN VLOTEN - Bellingham MA, US
Deping WANG - Sharon MA, US
Lei ZHANG - Westford MA, US
Daniel ERLANSON - San Francisco CA, US

International Classification:

C07D 471/04
C07D 213/82
C07D 213/85
C07D 241/26
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/04
C07D 409/14
C07D 417/14
C07D 473/34
C07D 487/04
C07D 491/052
C07D 519/00
C07D 241/28
C07D 498/04
A61K 31/437
A61K 31/4439
A61K 31/444
A61K 31/452
A61K 31/4725
A61K 31/496
A61K 31/497
A61K 31/498
A61K 31/4985
A61K 31/517
A61K 31/519
A61K 31/53
A61K 31/5377
A61K 31/5383

Abstract:

The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.