Lei Zhang

US Patent:

20110207622, Aug 25, 2011

Filed:

Feb 10, 2011

Appl. No.:

13/025130

Inventors:

David T. WONG - Beverly Hills CA, US
Lei Zhang - Los Angeles CA, US
Hua Xiao - Irvine CA, US
Hui Zhou - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C40B 30/04
C12Q 1/68
C40B 30/00
C12Q 1/02
G01N 33/566
G01N 21/64
C07K 17/00
C07H 21/00
G01N 33/48
H01J 49/26

US Classification:

506 9, 435 614, 435 612, 506 7, 435 29, 435 71, 436501, 435 613, 5303911, 536 2433, 435 792, 73 6143, 250282

Abstract:

Presented herein are biomarkers related to lung cancer. The presently identified salivary biomarkers create the basis for a lung cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed lung cancer assay in clinical, diagnostic and therapeutic uses is also included.

US Patent:

20110212851, Sep 1, 2011

Filed:

Feb 10, 2011

Appl. No.:

13/025110

Inventors:

David T. WONG - Beverly Hills CA, US
Lei Zhang - Los Angeles CA, US
Hua Xiao - Irvine CA, US
Hui Zhou - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C40B 30/04
C12Q 1/32
C12Q 1/527
C12Q 1/68
C40B 30/00
G01N 33/573
G01N 33/566
G01N 21/64
C12Q 1/02
C07K 17/00
C07H 21/00
G01N 33/48
H01J 49/26

US Classification:

506 9, 435 26, 435 4, 435 612, 506 7, 436501, 435 74, 435 792, 435 71, 435 29, 5303911, 536 2433, 73 6143, 250282

Abstract:

Presented herein are biomarkers related to breast cancer. The presently identified salivary biomarkers create the basis for a breast cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed breast cancer assay in clinical, diagnostic and therapeutic uses is also included.

US Patent:

20120196764, Aug 2, 2012

Filed:

Jun 25, 2010

Appl. No.:

13/379341

Inventors:

Lei Zhang - Los Angeles CA, US
David T. Wong - Beverly Hills CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C40B 30/04
C12Q 1/68

US Classification:

506 9, 435 612

Abstract:

The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing pancreatic cancer and distinguishing between pancreatic cancer and chronic pancreatitis. The present invention additionally provides kits that find use in the practice of the methods of the invention.

US Patent:

20220221968, Jul 14, 2022

Filed:

Dec 17, 2021

Appl. No.:

17/644989

Inventors:

- Santa Monica CA, US
Andrew Grosvenor Cooper - Los Angeles CA, US
Yamill Antonio Vallecillo - Los Angeles CA, US
Sivakumar Loganathan - San Francisco CA, US
Lei Zhang - Mountain View CA, US

International Classification:

G06F 3/0485
G06F 3/0481
H04N 5/232
G06F 3/04883
H04N 21/47
H04N 21/431

Abstract:

A panoramic system can receive content (e.g., live video) recorded in a landscape orientation and use a portrait dynamic crop window to display a portrait area of the received content. The panoramic system can further display the content in a landscape dynamic crop window that has a moveable user interface control that can pan the portrait crop window as the content plays in one or both of the dynamic crop windows.

US Patent:

20210369808, Dec 2, 2021

Filed:

Aug 9, 2021

Appl. No.:

17/397927

Inventors:

- University Park PA, US
Lei ZHANG - State College PA, US
Hana YEH - State College PA, US
Grace LEE - State College PA, US

International Classification:

A61K 38/05
A61K 31/519
C12N 5/0793
A61K 31/4439
A61K 31/506
A61K 31/00

Abstract:

Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG; purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

US Patent:

20210032300, Feb 4, 2021

Filed:

Feb 1, 2019

Appl. No.:

16/966691

Inventors:

- University Park PA, US
Lei Zhang - University Park PA, US
Ziyuan Guo - State College PA, US
Zifei Pei - University Park PA, US

International Classification:

C07K 14/47
A61P 25/00
C12N 15/86
C12N 7/00
A61K 9/00
C12N 9/12

Abstract:

This document provides methods and materials for treating brain injuries. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide to convert reactive astrocytes within a brain (e.g., cerebral cortex) into functional neurons (e.g., neurons that can be functionally integrated into the brain of a living mammal (e.g., a human)) are provided.

US Patent:

20200023030, Jan 23, 2020

Filed:

Sep 30, 2019

Appl. No.:

16/588054

Inventors:

- University Park PA, US
Lei ZHANG - State College PA, US
Hana YEH - State College PA, US
Grace LEE - State College PA, US

International Classification:

A61K 38/05
A61K 31/519
C12N 5/0793
A61K 31/4439
A61K 31/506
A61K 31/00

Abstract:

Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

US Patent:

20180148688, May 31, 2018

Filed:

Dec 1, 2017

Appl. No.:

15/828652

Inventors:

- University Park PA, US
Lei Zhang - State College PA, US
Ningxin Ma - State College PA, US

International Classification:

C12N 5/0793
A61K 31/375
A61K 31/192
A61K 31/4418
A61K 31/4545
A61K 31/506
A61K 33/14

Abstract:

Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional neurons.